高校生アスリートの水分出納

This study was conducted to assess water balance under 2h-sedentary or 2h-exercise training in 8 athlete high school students. Whole-body sweat loss（WBSL）was calculated using this Equation［WBSL（L）=（Pre-exercise body mass（kg）−Post-exercise body mass（kg））+Fluid intake（L）−Urine output （L）］. Urine and WHSL decreased and increased from 249±117 ml and 306±155 ml in 2h-sedentary to 64±34 ml and 1764±1243 ml in 2h-excercise training, respectively. In conclusion, sweat losses became a major factor in whole-body water balance in exercise training

<Abstract of published report>Stimulation of Nerve Growth Factor Synthesis/Secretion by 1,4-Benzoquinone and Its Derivatives in Cultured Mouse Astroglial Cells

AbstractPreviously we reported that astroglial cells cultured from mouse brain synthesize and secrete nerve growth factor (NGF) and that, in quiescent cells, catecholamines markedly increase the NGF content in the conditioned medium (CM). We wished to further assess the structural properties required for exhibition of such effect of compounds containing a ring structure analogous to that of catechol on astroglial NGF synthesis. During our study, we found that hydroquinone, which was confirmed not to stimulate NGF synthesis in mouse flbroblast cells in another of our investigations, is a potent stimulator of NGF synthesis in astroglial cells and that 1,4-benzoquinone, an oxidized form of hydroquinone, is a more effective stimulator than hydroquinone itself. In addition, the results of experiments with 1,2-benzoquinone derivatives indicated that the presence of a long aliphatic side chain in the molecule eliminates the stimulatory effect of 1,4-benzoquinone on NGF synthesis in astroglial cells

Granulocyte Colony-Stimulating Factor-Producing Gallbladder Cancer

We report a case of a granulocyte colony-stimulating factor (G-CSF)-producing gallbladder tumor associated with fever in a middle-aged female. Preoperative blood analysis showed leukocytosis with elevated levels of C-reactive protein and G-CSF. We resected the liver at S4a＋S5, with regional lymph node dissection and partial resection of the duodenum. Histology revealed undifferentiated carcinoma with spindle and giant cells and papillary adenocarcinoma. Immunohistochemistry revealed Stage IIIB G-CSF-producing gallbladder cancer. Postoperatively, leukocyte and serum G-CSF levels decreased to within normal limits. Adjuvant gemcitabine chemotherapy was administered for 16 months, and she has been recurrence-free for 48 months

How Are Statistical Parameters of the Velocity Vector of Body Sway Distributed in Normal Human Subjects?

The velocity vector when the human body sways has been qualitatively evaluated in clinical sessions. We quantitatively measured the velocity vector for 1 min in 89 normal subjects standing in a stable posture, and examined distributions of quantities of the velocity vector. The velocity vector was measured with a stabilometer, which visualizes the vector as magnitudes radially projected from the center to the periphery into 36 directions by 10°. The 3 quantities we calculated from the 36 scalars of the vector per subject were the coefficient of correlation (CV), skewness and kurtosis, which were analyzed statistically. Values of skewness were normally distributed. Values of CV and kurtosis were log-normally distributed when adjusted with log transformation. Then, we calculated standardized values of the normal distributions, from which the lower and upper cutoff values in the 95% and 99% areas were available. The 3 quantities showed statistically significant correlations with one another, although the levels were low. Thus, in the present study, use of the 3 parameters enabled us to quantitatively evaluate the whole image of velocity vector, which would simplify the procedures of examination and shorten the time required for differential diagnosis

Directly-observed therapy (DOT) for the radical 14-day primaquine treatment of Plasmodium vivax malaria on the Thai-Myanmar border

<p>Abstract</p> <p>Background</p> <p><it>Plasmodium vivax </it>has a dormant hepatic stage, called the hypnozoite, which can cause relapse months after the initial attack. For 50 years, primaquine has been used as a hypnozoitocide to radically cure <it>P. vivax </it>infection, but major concerns remain regarding the side-effects of the drug and adherence to the 14-day regimen. This study examined the effectiveness of using the directly-observed therapy (DOT) method for the radical treatment of <it>P. vivax </it>malaria infection, to prevent reappearance of the parasite within the 90-day follow-up period. Other potential risk factors for the reappearance of <it>P. vivax </it>were also explored.</p> <p>Methods</p> <p>A randomized trial was conducted from May 2007 to January 2009 in a low malaria transmission area along the Thai-Myanmar border. Patients aged ≥ 3 years diagnosed with <it>P. vivax </it>by microscopy, were recruited. All patients were treated with the national standard regimen of chloroquine for three days followed by primaquine for 14 days. Patients were randomized to receive DOT or self-administered therapy (SAT). All patients were followed for three months to check for any reappearance of <it>P. vivax</it>.</p> <p>Results</p> <p>Of the 216 patients enrolled, 109 were randomized to DOT and 107 to SAT. All patients recovered without serious adverse effects. The vivax reappearance rate was significantly lower in the DOT group than the SAT group (3.4/10,000 person-days vs. 13.5/10,000 person-days, <it>p </it>= 0.021). Factors related to the reappearance of vivax malaria included inadequate total primaquine dosage received (< 2.75 mg/kg), duration of fever ≤ 2 days before initiation of treatment, parasite count on admission ≥ 10,000/µl, multiple <it>P. vivax</it>-genotype infection, and presence of <it>P. falciparum </it>infection during the follow-up period.</p> <p>Conclusions</p> <p>Adherence to the 14-day primaquine regimen is important for the radical cure of <it>P. vivax </it>malaria infection. Implementation of DOT reduces the reappearance rate of the parasite, and may subsequently decrease <it>P. vivax </it>transmission in the area.</p

タベモノ ノ タビ : ケンコウ キョウイク ト リカ キョウイク ノ ティーム ティーチング

A nursing teacher and a science teacher carried out team teaching of health and science education. The nursing teacher has a special activity of health education in first grade of Fuzoku Elementary School. Aim of the activity is to alter their attitude (receptivity to be dirty) against feces. The nursing teacher stresses importance to check shape of their feces for health. Boys and girls checked shape of their feces for five days with their parents at their home. They discussed on shape of feces and health on the base of their results. In connection with this the science teacher tells subsequently about circulation of organic matters in nature. After this activity, it was confirmed that their attitude changed to better.国立情報学研究所『研究紀要公開支援事業』により電子化