An Analysis of Mechanical Constraints when Using Superconducting Gravimeters for Far-Field Pre-Seismic Anomaly Detection

Pre-seismic gravity anomalies from records obtained at a 1 Hz sampling rate from superconducting gravimeters (SG) around East Asia are analyzed. A comparison of gravity anomalies to the source parameters of associated earthquakes shows that the detection of pre-seismic gravity anomalies is constrained by several mechanical conditions of the seismic fault plane. The constraints of the far-field pre-seismic gravity amplitude perturbation were examined and the critical spatial relationship between the SG station and the epicenter precursory signal for detection was determined. The results show that: (1) the pre-seismic amplitude perturbation of gravity is inversely proportional to distance; (2) the transfer path from the epicenter to the SG station that crosses a tectonic boundary has a relatively low pre-seismic gravity anomaly amplitude; (3) the pre-seismic gravity perturbation amplitude is also affected by the attitude between the location of an SG station and the strike of the ruptured fault plane. The removal of typhoon effects and the selection of SG stations within a certain intersection angle to the strike of the fault plane are essential for obtaining reliable pre-seismic gravity anomaly results

Sediment-Mass Accumulation Rate and Variability in the East China Sea Detected by GRACE

The East China Sea (ECS) is a region with shallow continental shelves and a mixed oceanic circulation system allowing sediments to deposit on its inner shelf, particularly near the estuary of the Yangtze River. The seasonal northward-flowing Taiwan Warm Current and southward-flowing China Coastal Current trap sediments from the Yangtze River, which are accumulated over time at rates of up to a few mm/year in equivalent water height. Here, we use the Gravity Recovery and Climate Experiment (GRACE) gravity products from three data centres to determine sediment mass accumulation rates (MARs) and variability on the ECS inner shelf. We restore the atmospheric and oceanic effects to avoid model contaminations on gravity signals associated with sediment masses. We apply destriping and spatial filters to improve the gravity signals from GRACE and use the Global Land Data Assimilation System to reduce land leakage. The GRACE-derived MARs over April 2002–March 2015 on the ECS inner shelf are about 6 mm/year and have magnitudes and spatial patterns consistent with those from sediment-core measurements. The GRACE-derived monthly sediment depositions show variations at time scales ranging from six months to more than two years. Typically, a positive mass balance of sediment deposition occurs in late fall to early winter when the southward coastal currents prevail. A negative mass balance happens in summer when the coastal currents are northward. We identify quasi-biennial sediment variations, which are likely to be caused by quasi-biennial variations in rain and erosion in the Yangtze River basin. We briefly explain the mechanisms of such frequency-dependent variations in the GRACE-derived ECS sediment deposition. There is no clear perturbation on sediment deposition over the ECS inner shelf induced by the Three Gorges Dam. The limitations of GRACE in resolving sediment deposition are its low spatial resolution (about 250 km) and possible contaminations by land hydrological and oceanic signals. Potential GRACE-derived sediment depositions in six major estuaries are presented

The antimicrobial efficacy of Fructus mume extract on orthodontic bracket: a monospecies-biofilm model study in vitro

Objective: The aim of this study was to evaluate the antimicrobial efficacy of Traditional Chinese Medicine Fructus mume on a monospecies-biofilm model established on orthodontic brackets in vitro. Materials and methods: The antimicrobial effect of Fructus mume aqueous extract on the planktonic Streptococcus mutans (S. mutans) was tested by microdilution method (MIC). The cell viability of S. mutans biofilm on Damon3 MX bracket (Ormco, USA) after exposed to Fructus mume extract was quantified by XTT reduction assay. Visualization of the samples was performed by fluorescence microscope and confocal laser scanning microscopy (CLSM). Results: HPLC analysis revealed that the main compounds of Fructus mume are organic acids. The MIC of Fructus mume extract on the planktonic S. mutans was 50 mg/mL. The optical density (OD) values, measured by XTT reduction assay from S. mutans biofilms after 1-min exposure to different test agents, demonstrated that the cell viability of S. mutans biofilms exposed to 250 mg/mL Fructus mume extract < BHI (-) (p < 0.01). Microscope image showed that Fructus mume extract obviously increased the amount of dead bacteria on the surface of bracket. Conclusion: Fructus mume extract showed antimicrobial effect on S. mutans biofilm on orthodontic bracket in vitro which may indicate its potential use as an oral antimicrobial agent for orthodontic patients. © 2010 Elsevier Ltd. All rights reserved.postprin

Erosion effects assessed by repeated gravity measurements in southern Taiwan

International audienceWe analyse temporal variations of gravity measured in southern Taiwan since November 2006 at 10 sites using absolute gravimeters and, since November 2008, at 70 sites using a relative gravimeter. We describe and apply methods to interpret the gravity changes in terms of local hydrological processes and vertical ground motions. The effect of land water is computed from local rainfall data and a model of rain accumulation and discharge in the ground. The effect of the vertical motions of the ground is estimated using time-series of permanent Global Positioning System (GPS) stations and the theoretical gravity to height ratio of −2 μGal cm−1. Unexpectedly, Morakot typhoon (2009 August), the strongest typhoon in Taiwan in 50 yr, was responsible for the highest gravity changes. Morakot triggered numerous large landslides and debris flow deposits. Their thicknesses are estimated from the gravity changes (up to ∼280 μGal) along with field observations and satellite images

Absolute gravity change in Taiwan: Present result of geodynamic process investigation

Gravity values at 24 sites over 2004 - 2016 measured with absolute gravimeters are used to study geodynamic processes in Taiwan. We model rain-induced grav­ity effects and other temporal effects of non-geodynamic origins to obtain residual gravity, which cannot be fully explained by GPS-derived vertical displacements. We explain the gravity changes associated with deposited debris, earthquake, volcanism and Moho deepening. Gravity changes of 53.37 and 23.38 μGal near Sinwulyu and Laonong Rivers are caused by typhoon Morakot, leading to estimated volumes of 6.0 × 105 and 3.6 × 105 m3 in deposited debris. The observed co-seismic gravity change near the epicenter of the M 6.9 Pingtung earthquake (26 December 2006) is 3.12 ± 0.99 μGal, consistent with a dislocation-based gravity change at the μGal level, thereby supplying a gravity constraint on the modeled fault parameters. The AG re­cord at the Tatun Volcano Group is the longest, but large temporal gravity effects here has led to a current gravity signal-to-noise ratio of less than one, which cannot convince a sinking magma chamber, but supply an error bound for gravity detections of long-term or transient magma movements. The gravity values at Ludao and Lanyu decline steadily at the rates of -2.20 and -0.50 μGal yr-1, consistent with the expected magma states of the two extinct volcanoes. The gravity rates at an uplifting site in central Taiwan and three subsiding sites in eastern Taiwan are negative, and are po­tentially caused by Moho deepening at a rate of -3.34 cm yr-1 and a combined Moho deepening and plate subduction at the rates of -0.18, -2.03, and -1.34 cm yr-1

Molecular Characterization of Fluoroquinolone Resistance in Mycobacterium tuberculosis: Functional Analysis of gyrA Mutation at Position 74▿ †

A PCR-sequencing assay was evaluated for direct detection of mutations in the quinolone resistance-determining region (QRDR) of gyrase A (gyrA) gene in fluoroquinolone-resistant Mycobacterium tuberculosis in respiratory specimens. As determined by gyrA QRDR analysis, complete concordance of genotypic and phenotypic fluoroquinolone resistance was demonstrated. Our results indicate that the assay is a rapid and reliable method for the diagnosis of fluoroquinolone-resistant tuberculosis, facilitating timely clinical management and public health control. Using the assay, we detected a novel gyrA Ala74Ser mutation in M. tuberculosis directly from sputum specimens. The functional effect of the Ala74Ser mutant was verified through the study of the DNA supercoiling inhibitory activity of fluoroquinolones against the recombinant gyrase. The drug-mediated gyrase-DNA cleavage complex model suggests perturbation of the gyrA-gyrA dimer interface caused by the Ala74Ser mutation probably disturbs the putative quinolone binding pocket and leads to the reduction of the drug binding affinity. A number of gyrA mutations (Glu21Gln, Ser95Thr, and Gly668Asp) were also characterized to be natural polymorphisms not associated with fluoroquinolone resistance