Citizen Science with GIS&T

Citizen Science is defined as the participation of non-professional volunteers in scientific projects (Dickson et al, 2010) and has experienced rapid growth over the past decade. The projects that are emerging in this area range from contributory projects, co-created projects, collegiate projects, which are initiated and run by a group of people with shared interest, without any involvement of professional scientists. In many citizen science projects, GIS&T is enabling the collection, analysis, and visualisation of spatial data to affect decision-making. Some examples may include: Recording the location of invasive species or participating in a BioBlitz to record local biodiversity (Figure 1). Measuring air quality or noise over a large area and over time to monitor local conditions and address them Using tools to educate on and increase access to local resources, improving community resilience Such projects have the opportunity to empower or disempower members of the public, depending upon access to and understanding of technology. Citizen Science projects using GIS&T may help communities influence decision makers and support the gathering of large-scale scientific evidence on a range of issues. This may also renew people’s interests in the sciences and foster continued and lifelong learning

Organizational Characteristics of High- and Low-Clozapine-Utilization Clinics in the Veterans Health Administration

Objective: Treatment-resistance schizophrenia occurs in 20-30% of patients. Clozapine is the only medication proven effective for treatment-resistant schizophrenia. However, less than 25% of treatment-resistant schizophrenia patients receive clozapine in most settings. Therefore, this study was conducted to identify facilitators and barriers to clozapine use, to inform development of interventions to maximize appropriate clozapine-utilization. Methods: Seventy semi-structured phone interviews were conducted with five high- and five low-utilization VA Medical Centers, from different US regions including urban and rural areas. Interviewees were key informants of clozapine processes, including mental health leadership, psychiatrists, clinical pharmacists and advanced practice nurses. Interviews were analyzed using an emergent thematic strategy to identify barriers and facilitators to clozapine prescribing. Results: Key elements associated with high-utilization included integration of non-physician psychiatric providers and clear organizational processes and infrastructure for treatment of severe mental illness (e.g. clozapine clinics, larger mental health intensive case management services). Low-utilization was associated with lack of champions to support clozapine processes and limited-capacity care systems. Obstacles identified at both high- and low-utilization sites included complex time-consuming paperwork, reliance on few individuals to facilitate processes, and issues related to transportation for patients living far from care facilities. Conclusions: Implementation efforts to organize, streamline and simplify clozapine processes, development of a multidisciplinary clozapine clinic, increasing the size and capacity of existing clinics, and provision of transportation are reasonable targets to increase clozapine utilization

Evidence for the Gompertz Curve in the Income Distribution of Brazil 1978-2005

This work presents an empirical study of the evolution of the personal income distribution in Brazil. Yearly samples available from 1978 to 2005 were studied and evidence was found that the complementary cumulative distribution of personal income for 99% of the economically less favorable population is well represented by a Gompertz curve of the form $G(x)=\exp [\exp (A-Bx)]$, where $x$ is the normalized individual income. The complementary cumulative distribution of the remaining 1% richest part of the population is well represented by a Pareto power law distribution $P(x)= \beta x^{-\alpha}$. This result means that similarly to other countries, Brazil's income distribution is characterized by a well defined two class system. The parameters $A$, $B$, $\alpha$, $\beta$ were determined by a mixture of boundary conditions, normalization and fitting methods for every year in the time span of this study. Since the Gompertz curve is characteristic of growth models, its presence here suggests that these patterns in income distribution could be a consequence of the growth dynamics of the underlying economic system. In addition, we found out that the percentage share of both the Gompertzian and Paretian components relative to the total income shows an approximate cycling pattern with periods of about 4 years and whose maximum and minimum peaks in each component alternate at about every 2 years. This finding suggests that the growth dynamics of Brazil's economic system might possibly follow a Goodwin-type class model dynamics based on the application of the Lotka-Volterra equation to economic growth and cycle.Comment: 22 pages, 15 figures, 4 tables. LaTeX. Accepted for publication in "The European Physical Journal B

Mirror Symmetry and Other Miracles in Superstring Theory

The dominance of string theory in the research landscape of quantum gravity physics (despite any direct experimental evidence) can, I think, be justified in a variety of ways. Here I focus on an argument from mathematical fertility, broadly similar to Hilary Putnam's 'no miracles argument' that, I argue, many string theorists in fact espouse. String theory leads to many surprising, useful, and well-confirmed mathematical 'predictions' - here I focus on mirror symmetry. These predictions are made on the basis of general physical principles entering into string theory. The success of the mathematical predictions are then seen as evidence for framework that generated them. I attempt to defend this argument, but there are nonetheless some serious objections to be faced. These objections can only be evaded at a high (philosophical) price.Comment: For submission to a Foundations of Physics special issue on "Forty Years Of String Theory: Reflecting On the Foundations" (edited by G. `t Hooft, E. Verlinde, D. Dieks and S. de Haro)

Cancer and thrombosis: Managing the risks and approaches to thromboprophylaxis

Patients with cancer are at increased risk of venous thromboembolism (VTE) compared with patients without cancer. This results from both the prothrombotic effects of the cancer itself and iatrogenic factors, such as chemotherapy, radiotherapy, indwelling central venous devices and surgery, that further increase the risk of VTE. Although cancer-associated thrombosis remains an important cause of morbidity and mortality, it is often underdiagnosed and undertreated. However, evidence is accumulating to support the use of low-molecular-weight heparins (LMWHs) in the secondary prevention of VTE in patients with cancer. Not only have LMWHs been shown to be at least as effective as coumarin derivatives in this setting, but they have a lower incidence of complications, including bleeding, and are not associated with the practical problems of warfarin therapy. Furthermore, a growing number of studies indicate that LMWHs may improve survival among patients with cancer due to a possible antitumor effect. Current evidence suggests that LMWHs should increasingly be considered for the long-term management of VTE in patients with cancer

Using space syntax and historical land-use data to interrogate narratives of high street ‘decline’ in two Greater London suburbs

The purpose of this paper is to provide some much needed theoretical grounding and historical-morphological context for the narratives of communal loss that recur in the reportage concerning the British high street. Given the topicality of this issue for policy-makers it is worth enquiring into precisely how far such narratives are in fact supported by a long-term perspective on historical changes in high street land uses in relation to the evolving spatial morphology of small town centres, in order to better distinguish the extent to which a further layer of socio-cultural explanation is required to account for the concern over ‘decline’. This research, undertaken as part of the EPSRC Adaptable Suburbs project at UCL, uses fully digitized historical maps, contemporary and historical land use data and space syntax analysis to identify historical-morphological parameters of change and continuity in and around two suburban high streets of Greater London since the nineteenth century: Surbiton and South Norwood. Drawing on Hillier and colleagues’ theory of ‘movement economy, the contemporary English high street, as it is represented in the case-study areas, emerges as a distinctive and resilient spatial morphology which has supported varied modes of land use over time. It concludes that the narrative of high street decline in part reflects a dominant focus on difficulties facing the UK retail sector and that a broader focus on the high street as a (re)generative social space rather than simply as a ‘retail attractor’ would allow for a broader appreciation of both its morphological and socio-economic capacities

Studying complex interventions : reflections from the FEMHealth project on evaluating fee exemption policies in West Africa and Morocco

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