A research study of the prevalence of venereal disease among senior high-school boys and the attitude of the community toward venereal instruction

Not Available.Ralph S. RichardsonNot ListedNot ListedMaster of ScienceDepartment Not ListedCunningham Memorial library, Terre Haute, Indiana State University.isua-thesis-1940-richardson.pdfMastersTitle from document title page. Document formatted into pages: contains 98p. : ill. Includes appendix

Integrable model for interacting electrons in metallic grains

We find an integrable generalization of the BCS model with non-uniform Coulomb and pairing interaction. The Hamiltonian is integrable by construction since it is a functional of commuting operators; these operators, which therefore are constants of motion of the model, contain the anisotropic Gaudin Hamiltonians. The exact solution is obtained diagonalizing them by means of Bethe Ansatz. Uniform pairing and Coulomb interaction are obtained as the ``isotropic limit'' of the Gaudin Hamiltonians. We discuss possible applications of this model to a single grain and to a system of few interacting grains.Comment: 4 pages, revtex. Revised version to be published in Phys. Rev. Let

Isolated quadriceps training restores whole body exercise capacity in CHF

Patients with Chronic Heart Failure (CHF) are commonly characterized by exercise limitation. The benefit of isolated (i.e., small muscle mass) muscle training and its potential translation to whole body exercise in patients CHF has been recognized, however the mechanisms responsible for this positive outcome remain poorly understood. To study oxygen (O2) transport and metabolism at maximal cycle (whole body) and knee extensor (KE, small muscle mass) exercise in this pathological condition, eight healthy controls and six patients with CHF with reduced ejection fraction commenced 8 weeks of KE training (both legs, separately). Before and after training, they underwent cycle and KE maximal exercise studies. Pre-training cycling and KE exercise peak leg O2 uptake (VO2) were 17% and 15% lower, respectively, in the patients compared to controls. Although KE training did not alter cardiac output at maximal KE or cycle exercise, it increased O2 delivery (by 54%), arterial-venous O2 difference (by 10%), and muscle O2 conductance (by 39%) at maximal KE exercise, yielding an increase in peak single leg VO2 of 53%, which exceeded untrained control subject values. Post-training, during maximal cycling, O2 delivery (40%), arterial-venous O2 difference (15%), and muscle O2 conductance (DMO2) (52%) all increased, yielding a 40% greater peak leg VO2, matching that of the controls. Small muscle mass exercise training-induced improvements in both peripheral convective and diffusive O2 transport and subsequent O2 utilization were the main mechanisms responsible for the increased whole body exercise capacity in patients with CHF. Such clear improvements in these factors and exercise capacity support the efficacy of small muscle mass training as a powerful approach to promote a metabolic reserve and maintain physical function in the face of continuing central limitations associated with CHF

Thermodynamic properties of a small superconducting grain

The reduced BCS Hamiltonian for a metallic grain with a finite number of electrons is considered. The crossover between the ultrasmall regime, in which the level spacing, $d$, is larger than the bulk superconducting gap, $\Delta$, and the small regime, where $\Delta \gtrsim d$, is investigated analytically and numerically. The condensation energy, spin magnetization and tunneling peak spectrum are calculated analytically in the ultrasmall regime, using an approximation controlled by $1/\ln N$ as small parameter, where $N$ is the number of interacting electron pairs. The condensation energy in this regime is perturbative in the coupling constant $\lambda$, and is proportional to $d N \lambda^2 = \lambda^2 \omega_D$. We find that also in a large regime with $\Delta>d$, in which pairing correlations are already rather well developed, the perturbative part of the condensation energy is larger than the singular, BCS, part. The condition for the condensation energy to be well approximated by the BCS result is found to be roughly $\Delta > \sqrt{d \omega_D}$. We show how the condensation energy can, in principle, be extracted from a measurement of the spin magnetization curve, and find a re-entrant susceptibility at zero temperature as a function of magnetic field, which can serve as a sensitive probe for the existence of superconducting correlations in ultrasmall grains. Numerical results are presented which suggest that in the large $N$ limit the 1/N correction to the BCS result for the condensation energy is larger than $\Delta$.Comment: 17 pages, 7 figures, Submitted to Phys. Rev.

Impact of Pre-Exposure History and Host Genetics on Antibody Avidity Following Norovirus Vaccination

Background: Development of high avidity, broadly neutralizing antibodies (Abs) is a priority after vaccination against rapidly evolving, widely disseminated viruses like human norovirus. After vaccination with a multivalent GI.1 and GII.4c norovirus virus-like particle (VLP) vaccine candidate adjuvanted with alum and monophosphoryl lipid A (MPL), blockade Ab titers peaked early, with no increase in titer following a second vaccine dose. Methods: Blockade Ab relative avidity was evaluated by measuring the slope of blockade Ab neutralization curves. Results: Blockade Ab avidity to the GI.1 vaccine component peaked at day 35 (7 days after dose 2). Avidities to heterotypic genogroup I VLPs were not sustained at day 35 after vaccination or GI.1 infection, as measured from archived sera. Only secretor-positive participants maintained high avidity blockade Ab to GI.1 at day 180. Avidity to the GII.4c vaccine component peaked at day 7, remained elevated through day 180, and was not secretor dependent. Avidity to an immunologically novel GII.4 strain VLP correlated with preexisting Ab titer to an ancestral strain Epitope A. Conclusions: Host genetics and pre-exposure history shape norovirus vaccine Ab responses, including blockade Ab avidity. Avidity of potentially neutralizing Ab may be an important metric for evaluating vaccine responses to highly penetrant viruses with cross-reactive serotypes

Squeezed light from a coherently pumped four-level laser

We calculate the amplitude squeezing in the output of a coherently pumped four-level laser and compare it with that from a similar incoherently pumped laser. We find that squeezing may be considerably enhanced by pumping with coherent light. The squeezing in both types of laser is explained by a simple statistical model