Market research in standard setting

Market research in standard settin

Additional file 1: of What is the impact of regulatory guidance and expiry of drug patents on dementia drug prescriptions in England? A trend analysis in the Clinical Practice Research Datalink

Analysis of the representativeness of the CPRD. (PDF 343 kb

Additional file 2: of What is the impact of regulatory guidance and expiry of drug patents on dementia drug prescriptions in England? A trend analysis in the Clinical Practice Research Datalink

Analysis of the sensitivity and specificity of the diagnoses. (PDF 438 kb

Additional file 2: of Cost-effectiveness of prostate cancer screening: a systematic review of decision-analytical models

Term used for conservative management. A summary table of the terms and definitions of conservative management used (DOCX 12 kb

Additional file 1: of Association of SNPs in LCP1 and CTIF with hearing in 11Â year old children: Findings from the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort and the G-EAR consortium

Results for all the SNPs included in the analyses of data from ALSPAC or G-EAR

Panel A: Scanning electron photomicrograph of 20:80 CPTEG:CPH nanoparticles loaded with 5% IVM, 5% DOX, and 2% rhodamine.

<p>Scale bar: 500 nm. Panel B: Release kinetics of ivermectin (IVM) and doxycycline (DOX) from 20:80 CPTEG:CPH nanoparticles quantified using HPLC.</p

Confocal microscopy of female <i>B</i>. <i>malayi</i> with nanoparticles.

<p>Worms were incubated for 96 h with either soluble controls (panel A) or 20:80 CPTEG:CPH nanoparticles containing ivermectin (IVM), doxycycline (DOX), and rhodamine B (panel B), fixed and imaged by LSCM. Controls contained 195 μM each of IVM and DOX, and 3.9 μM rhodamine B, while the nanoparticles contained 5 μM of each drug and 0.1 μM of rhodamine B. Left panels are DNA (blue), rhodamine (red) and bright field image overlays and right panels are the respective individual rhodamine images collected using identical image acquisition settings. Inset box within the nanoparticle-treated worm outlines the area selected for side view rendering (C). Representative images shown demonstrate the accumulation of nanoparticles within tissues throughout the worm (B) as compared to the higher amount of soluble rhodamine that was not detected within the body of the worms.</p

Additional file 1: of Association of SNPs in LCP1 and CTIF with hearing in 11Â year old children: Findings from the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort and the G-EAR consortium

Results for all the SNPs included in the analyses of data from ALSPAC or G-EAR

The motility of <i>B</i>. <i>malayi</i> MF treated with decreasing doses of either soluble or encapsulated ivermectin (IVM)/doxycycline (DOX) was recorded for 14 days post treatment.

<p>The recorded motility scores (Panel B) were used to calculate an average time to death for each treatment group and dose (Panel A). To calculate the average motility score for each time, dose and treatment group, triplicate wells containing a minimum of 200 MF in each well were treated as indicated. A motility score of 0 was equated with death and the average time to death was plotted along with standard error. Data presented are from one of two experiments with similar results. Significance was determined at p<0.05, 0.01, or 0.001 as noted using a Student’s T test.</p

Panel A. Table outlining survival of <i>B</i>. <i>malayi</i> females after treatment with 195, 49, 10, 5, 1.95, or 0.049 μM concentrations of ivermectin (IVM) and doxycycline (DOX) delivered solubly or encapsulated into 20:80 CPTEG:CPH nanoparticles.

<p>Panel B. Average number of days to death of <i>B</i>. <i>malayi</i> females after administration of soluble or encapsulated IVM/DOX treatments and comparison to control worms. Significance was determined at p<0.05, 0.01, or 0.001 as noted using a Student’s T test. Panel C. Average motility scores of <i>B</i>. <i>malayi</i> females after IVM/DOX treatments scored using a 2X objective on a Nikon Microscope following a 0–5 scoring system, as described in the Methods. Panel D. Average number of microfilaria shed by <i>B</i>. <i>malayi</i> females after administration of soluble or encapsulated IVM/DOX treatments and comparison to control worms. The NP only group contains comparable amount of rhodamine and the total amount of particle in this group corresponds to that of the highest drug concentration of 195 μM. At 14 days, all worms treated with NP only with a motility score of 0 remained viable based on the MTT assay and recovery of motility upon transferring to fresh medium^†. Significance was determined at p<0.05, 0.01, or 0.001 as noted using a Student’s T test.</p