38,070 research outputs found

    Heterogeneous biomedical database integration using a hybrid strategy: a p53 cancer research database.

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    Complex problems in life science research give rise to multidisciplinary collaboration, and hence, to the need for heterogeneous database integration. The tumor suppressor p53 is mutated in close to 50% of human cancers, and a small drug-like molecule with the ability to restore native function to cancerous p53 mutants is a long-held medical goal of cancer treatment. The Cancer Research DataBase (CRDB) was designed in support of a project to find such small molecules. As a cancer informatics project, the CRDB involved small molecule data, computational docking results, functional assays, and protein structure data. As an example of the hybrid strategy for data integration, it combined the mediation and data warehousing approaches. This paper uses the CRDB to illustrate the hybrid strategy as a viable approach to heterogeneous data integration in biomedicine, and provides a design method for those considering similar systems. More efficient data sharing implies increased productivity, and, hopefully, improved chances of success in cancer research. (Code and database schemas are freely downloadable, http://www.igb.uci.edu/research/research.html.)

    Demographic Factors and Real House Prices

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    Real house prices are directly determined by the willingness of households to pay for (and willingness of builders to supply) a constant-quality house. Changes in the quantity of housing demanded will affect real prices only to the extent that the long-run housing supply schedule is positively sloped. In this paper we use 1980 census data to measure the impact of the age structure and real income per household on the willingness of households to pay for a constant quality house. Extrapolating these variables forward to 2010, we conclude that evolving demographic forces are likely to raise real house prices. not lower them.

    Impacts of U.S. Graduate Degree Training on Capacity Building in Developing Countries: A Case Study of the Pulse CRSP

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    The Dry Grain Pulses Collaborative Research Support Program (Pulse CRSP) had allocated a major part of its resources to providing graduate degree training (GDT) of scientists/researchers in order to strengthen agricultural research capacity in Africa, Latin America, and the U.S. However, no systematic attempt had been made to assess the impact of this investment. The study adopted the Kirkpatrick framework as a guide for evaluating the impacts of GDT by the Pulse CRSP. The results were drawn from a survey of former trainees and researchers, supplemented by interviews with scientists and program administrators and an institutional case study. An important finding was that over 86% of host country trainees returned to their home country. In their enhanced capacity, trainees made contributions to the advancement of bean/cowpea research that can be attributed to their graduate degree training. Trainees reported that their GDT was necessary for their professional development and was highly relevant to their current job responsibility.Impact assessment, Pulse CRSP, USAID, Training, Graduate degree, Beans, Cowpeas, International Development, Teaching/Communication/Extension/Profession, Q16-R&D-Agricultural technology-Biofuels-Agricultural Extension Services,

    Binscatter Regressions

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    We introduce the \texttt{Stata} (and \texttt{R}) package \textsf{Binsreg}, which implements the binscatter methods developed in \citet*{Cattaneo-Crump-Farrell-Feng_2019_Binscatter}. The package includes the commands \texttt{binsreg}, \texttt{binsregtest}, and \texttt{binsregselect}. The first command (\texttt{binsreg}) implements binscatter for the regression function and its derivatives, offering several point estimation, confidence intervals and confidence bands procedures, with particular focus on constructing binned scatter plots. The second command (\texttt{binsregtest}) implements hypothesis testing procedures for parametric specification and for nonparametric shape restrictions of the unknown regression function. Finally, the third command (\texttt{binsregselect}) implements data-driven number of bins selectors for binscatter implementation using either quantile-spaced or evenly-spaced binning/partitioning. All the commands allow for covariate adjustment, smoothness restrictions, weighting and clustering, among other features. A companion \texttt{R} package with the same capabilities is also available
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