A systematic review of Futsal literature

This document systematically reviews literature to provide a summary of evidence based research related to the sport of futsal. The review draws on diverse subjects including coaching, physiological, psychological, technical and tactical elements of the sport as well as reviewing subjects relating to the development of futsal. The methodology included a scoping study and review protocol to systematically review 601 documents relating to futsal; 44 of these documents were reviewed in the study. The review aims to provide a resource for fellow researchers, to study the sport and encourage further English language studies in futsal. To that end, gaps in the literature are highlighted by the researchers, and therefore this document acts as a guide for further study

The world at their feet: a combined historical ranking of nations competing in football and futsal

Some elite football players (e.g. Cristiano Ronaldo, Lionel Messi, Neymar and Andres Iniesta) endorse the benefits of futsal and express how it has helped them to develop as football players. This has contributed to an increase in futsal development activity, in some countries, leading to interest into the relationship between the two sports. A lack of research exists to explain the developmental relationship between the two sports, aside from anecdotal evidence from players, coaches and media commentators, some of whom acclaim futsal for its role in developing elite footballers. This study investigates the relationship which exists between the two sports, by providing the first ever combined historical rank of nations competing in futsal and football. The results highlight the most successful nations as well as a 'select group' that appear to be in an advantageous position to develop in future. It also provides indicative evidence as to the relationship between the two sports and recommends that both sports may be able to benefit from a more collaborative approach to development

Engineering microrobots for targeted cancer therapies from a medical perspective

Systemic chemotherapy remains the backbone of many cancer treatments. Due to its untargeted nature and the severe side effects it can cause, numerous nanomedicine approaches have been developed to overcome these issues. However, targeted delivery of therapeutics remains challenging. Engineering microrobots is increasingly receiving attention in this regard. Their functionalities, particularly their motility, allow microrobots to penetrate tissues and reach cancers more efficiently. Here, we highlight how different microrobots, ranging from tailor-made motile bacteria and tiny bubble-propelled microengines to hybrid spermbots, can be engineered to integrate sophisticated features optimised for precision-targeting of a wide range of cancers. Towards this, we highlight the importance of integrating clinicians, the public and cancer patients early on in the development of these novel technologies

Player migration and opportunity: examining the efficacy of the UEFA home-grown rule in six European football leagues.

The introduction of UEFAs home-grown rule occurred for the start of the 2006–2007 season with the full quota in place from the 2008–2009 season, which imposed quotas on European clubs. From 2008, clubs are required to have at least 8 players classified as home-grown in the 25-player squad, up from 4 in 2006–2007 and 6 in 2007–2008. This study examines the efficacy of this rule across the six major European leagues (England, France, Germany, Holland, Italy and Spain) in relation to playing opportunities (minutes played and appearances) between 1999 and 2015. This was also examined in relation to age. Since the home-grown rule was introduced for the six nations hosting the major leagues, the rule had different impacts by nationality. Only Germany saw significant increases in the proportion of minutes played by their players when comparing the periods before and after the home-grown rules were imposed. Holland, albeit seeing a slight decrease overall, saw significant increases for playing time for under 21s and 22- to 25-year olds. England and Italy were the two nations where statistically significant decreases in indigenous playing opportunities were recorded since the home-grown rules were introduced

Health Care Delivery Practices in Huntington's Disease Specialty Clinics : An International Survey

The CHDI Foundation, Inc. funds Enroll-HD and the activities of the Enroll-HD Care Improvement Committee, including the present survey. We would like to acknowledge the Enroll-HD and REGISTRY administrative staff that assisted in the recruitment of sites and sites that completed the survey.Peer reviewedPublisher PD

Ovarian Cancers Harbour Defects in Non-Homologous End Joining Resulting in Resistance to Rucaparib

Abstract Purpose: DNA damage defects are common in ovarian cancer and can be used to stratify treatment. Although most work has focused on homologous recombination (HR), DNA double-strand breaks are repaired primarily by nonhomologous end joining (NHEJ). Defects in NHEJ have been shown to contribute to genomic instability and have been associated with the development of chemoresistance. Experimental Design: NHEJ was assessed in a panel of ovarian cancer cell lines and 47 primary ascetic-derived ovarian cancer cultures, by measuring the ability of cell extracts to end-join linearized plasmid monomers into multimers. mRNA and protein expression of components of NHEJ was determined using RT-qPCR and Western blotting. Cytotoxicities of cisplatin and the PARP inhibitor rucaparib were assessed using sulforhodamine B (SRB) assays. HR function was assessed using γH2AX/RAD51 foci assay. Results: NHEJ was defective (D) in four of six cell lines and 20 of 47 primary cultures. NHEJ function was independent of HR competence (C). NHEJD cultures were resistant to rucaparib (P = 0.0022). When HR and NHEJ functions were taken into account, only NHEJC/HRD cultures were sensitive to rucaparib (compared with NHEJC/HRC P = 0.034, NHEJD/HRC P = 0.0002, and NHEJD/HRD P = 0.0045). The DNA-PK inhibitor, NU7441, induced resistance to rucaparib (P = 0.014) and HR function recovery in a BRCA1-defective cell line. Conclusions: This study has shown that NHEJ is defective in 40% of ovarian cancers, which is independent of HR function and associated with resistance to PARP inhibitors in ex vivo primary cultures. Clin Cancer Res; 23(8); 2050–60. ©2016 AACR.</jats:p

Prognostic models for predicting recurrence and survival in women with endometrial cancer

This is a protocol for a Cochrane Review (prognosis). The objectives are as follows: To review all prognostic models that combine two or more clinical, histological or molecular variables, or a combination of these variables, to provide an individualised assessment of risk of recurrence or death from disease and evaluate their performance to predict these outcomes in people undergoing curative treatment for endometrial cancer

A conserved Polϵ binding module in Ctf18-RFC is required for S-phase checkpoint activation downstream of Mec1

Defects during chromosome replication in eukaryotes activate a signaling pathway called the S-phase checkpoint, which produces a multifaceted response that preserves genome integrity at stalled DNA replication forks. Work with budding yeast showed that the ‘alternative clamp loader’ known as Ctf18-RFC acts by an unknown mechanism to activate the checkpoint kinase Rad53, which then mediates much of the checkpoint response. Here we show that budding yeast Ctf18-RFC associates with DNA polymerase epsilon, via an evolutionarily conserved ‘Pol ϵ binding module’ in Ctf18-RFC that is produced by interaction of the carboxyl terminus of Ctf18 with the Ctf8 and Dcc1 subunits. Mutations at the end of Ctf18 disrupt the integrity of the Pol ϵ binding module and block the S-phase checkpoint pathway, downstream of the Mec1 kinase that is the budding yeast orthologue of mammalian ATR. Similar defects in checkpoint activation are produced by mutations that displace Pol ϵ from the replisome. These findings indicate that the association of Ctf18-RFC with Pol ϵ at defective replication forks is a key step in activation of the S-phase checkpoint

Barriers and facilitators to physical activity and further digital exercise intervention among inactive British adolescents in secondary schools: a qualitative study with physical education teachers.

Background: Previous studies indicated that physical education programs in schools were unsuccessful to ameliorate physical activity (PA) behaviors among adolescents. This study investigated PE teachers’ perceptions of barriers and facilitators to PA and further digital exercise interventions among inactive British adolescents in secondary schools based on the Capability, Opportunity, Motivation, and Behavior (COM-B) model, the Behavior Change Wheel (BCW), and Theoretical Domains Framework (TDF). Method: A qualitative study was conducted among 156 PE teachers in England. deductive thematic analysis approach was applied to analyze data. Results: A comprehensive perception of PE teachers revealed 21 barriers to PA among inactive adolescents in secondary schools. The study findings show that barriers exist across all categories of the COM-B model in physical opportunity (7), reflective motivation (5), social opportunity (4), psychological capability (4) and physical capability (1). The majority of these barriers were reported in previous studies as being barriers to PA from the perspective of children and adolescents. This shows that the findings are consistent with the views of children and adolescents that participated in these studies. Particular salient barriers for inactive adolescents were reported and greater insight into their experiences was highlighted. The study reported the main sources of behavior, intervention functions, policy functions, and behavior change tools that can be used for future behavior change interventions to support inactive adolescents. Conclusion: The study recommends using its findings to design interventions for inactive adolescents to achieve recommended levels of physical activity (PA). The study’s comprehensive approach and evidence-based solutions provide extensive reference points for future intervention design, informing policy and contributing to enhancing support for inactive adolescents. Further development of digital exercise interventions, including conversational artificial intelligence (AI), is suggested to engage adolescents at scale and provide personalized support to overcome multiple barriers to PA