1,585 research outputs found
Counting Form Factors of Twist-Two Operators
We present a simple method to count the number of hadronic form factors based
on the partial wave formalism and crossing symmetry. In particular, we show
that the number of independent nucleon form factors of spin-n, twist-2
operators (the vector current and energy-momentum tensor being special
examples) is n+1. These generalized form factors define the generalized
(off-forward) parton distributions that have been studied extensively in the
recent literature. In proving this result, we also show how the J^{PC} rules
for onium states arise in the helicity formalism.Comment: 7 pages, LaTeX (revtex
Delayed Reheating and the Breakdown of Coherent Oscillations
We analyze the evolution of the perturbations in the inflaton field and
metric following the end of inflation. We present accurate analytic
approximations for the perturbations, showing that the coherent oscillations of
the post-inflationary condensate necessarily break down long before any current
phenomenological constraints require the universe to become radiation
dominated. Further, the breakdown occurs on length-scales equivalent to the
comoving post-inflationary horizon size. This work has implications for both
the inflationary "matching" problem, and the possible generation of a
stochastic gravitational wave background in the post-inflationary universe.Comment: 18 pages, 5 figures, v2: references added, extended discussion in
section
Subcellular organization of camkii in rat hippocampal pyramidal neurons: CaMKII in Dendritic Spines
Calcium/calmodulin-dependent protein kinase II (CaM-KII) plays a key role in N-methyl-D-aspartate (NMDA) receptor-dependent long-term synaptic plasticity; its location is critical for signal transduction, and may provide clues that further elucidate its function. We therefore examined the subcellular localization of CaMKII in CA1 stratum radiatum of adult rat hippocampus, by using immuno-electron microscopy after chemical fixation. When tissue was fixed quickly, the concentration of CaMKIIα (assessed by pre-embedding immunogold) was significantly higher in dendritic shafts than in spine heads. However, when tissue was fixed 5 minutes after perfusion with normal saline, the density of labeling decreased in dendritic shaft while increasing in spine heads, implying rapid translocation into the spine during brief perimortem stress. Likewise, in quickly fixed tissue, CaMKII within spine heads was found at comparable concentrations in the âproximalâ half (adjacent to the spine neck) and the âdistalâ half (containing the postsynaptic density [PSD]), whereas after delayed fixation, label density increased in the distal side of the spine head, suggesting that CaMKII within the spine head moves toward the PSD during this interval. To estimate its distribution at the synapse in vivo, we performed postembedding immunogold staining for CaMKII in quick-fixed tissue, and found that the enzyme did not concentrate primarily within the central matrix of the PSD. Instead, labeling density peaked âŒ40 nm inside the postsynaptic membrane, at the cytoplasmic fringe of the PSD. Labeling within 25 nm of the postsynaptic membrane concentrated at the lateral edge of the synapse. This lateral âPSD coreâ pool of CaMKII may play a special role in synaptic plasticity
Reduction and Emergence in Bose-Einstein Condensates
A closer look at some proposed Gedanken-experiments on BECs promises to shed
light on several aspects of reduction and emergence in physics. These include
the relations between classical descriptions and different quantum treatments
of macroscopic systems, and the emergence of new properties and even new
objects as a result of spontaneous symmetry breaking
A Two Micron All-Sky Survey View of the Sagittarius Dwarf Galaxy: II. Swope Telescope Spectroscopy of M Giant Stars in the Dynamically Cold Sagittarius Tidal Stream
We present moderate resolution (~6 km/s) spectroscopy of 284 M giant
candidates selected from the Two Micron All Sky Survey photometry. Radial
velocities (RVs) are presented for stars mainly in the south, with a number
having positions consistent with association to the trailing tidal tail of the
Sagittarius (Sgr) dwarf galaxy. The latter show a clear RV trend with orbital
longitude, as expected from models of the orbit and destruction of Sgr. A
minimum 8 kpc width of the trailing stream about the Sgr orbital midplane is
implied by verified RV members. The coldness of this stream (dispersion ~10
km/s) provides upper limits on the combined contributions of stream heating by
a lumpy Galactic halo and the intrinsic dispersion of released stars, which is
a function of the Sgr core mass. The Sgr trailing arm is consistent with a
Galactic halo containing one dominant, LMC-like lump, however some lumpier
halos are not ruled out. An upper limit to the total M/L of the Sgr core is 21
in solar units. A second structure that roughly mimics expectations for
wrapped, leading Sgr arm debris crosses the trailing arm in the Southern
Hemisphere; however, this may also be an unrelated tidal feature. Among the <13
kpc M giants toward the South Galactic Pole are some with large RVs that
identify them as halo stars, perhaps part of the Sgr leading arm near the Sun.
The positions and RVs of Southern Hemisphere M giants are compared with those
of southern globular clusters potentially stripped from the Sgr system and
support for association of Pal 2 and Pal 12 with Sgr debris is found. Our
discussion includes description of a masked-filtered cross-correlation
methodology that achieves better than 1/20 of a resolution element RVs in
moderate resolution spectra.Comment: 41 pages, 6 figures, Astronomical Journal, in press (submitted Nov.
24, 2003; tentatively scheduled for July 2004 issue
Pion-Nucleon Scattering in a Large-N Sigma Model
We review the large-N_c approach to meson-baryon scattering, including recent
interesting developments. We then study pion-nucleon scattering in a particular
variant of the linear sigma-model, in which the couplings of the sigma and pi
mesons to the nucleon are echoed by couplings to the entire tower of I=J
baryons (including the Delta) as dictated by large-N_c group theory. We sum the
complete set of multi-loop meson-exchange
\pi N --> \pi N and \pi N --> \sigma N Feynman diagrams, to leading order in
1/N_c. The key idea, reviewed in detail, is that large-N_c allows the
approximation of LOOP graphs by TREE graphs, so long as the loops contain at
least one baryon leg; trees, in turn, can be summed by solving classical
equations of motion. We exhibit the resulting partial-wave S-matrix and the
rich nucleon and Delta resonance spectrum of this simple model, comparing not
only to experiment but also to pion-nucleon scattering in the Skyrme model. The
moral is that much of the detailed structure of the meson-baryon S-matrix which
hitherto has been uncovered only with skyrmion methods, can also be described
by models with explicit baryon fields, thanks to the 1/N_c expansion.Comment: This LaTeX file inputs the ReVTeX macropackage; figures accompany i
The effects of iron fortification on the gut microbiota in African children: a randomized controlled trial in Cote d'Ivoire.
BACKGROUND: Iron is essential for the growth and virulence of many pathogenic enterobacteria, whereas beneficial barrier bacteria, such as lactobacilli, do not require iron. Thus, increasing colonic iron could select gut microbiota for humans that are unfavorable to the host. OBJECTIVE: The objective was to determine the effect of iron fortification on gut microbiota and gut inflammation in African children. DESIGN: In a 6-mo, randomized, double-blind, controlled trial, 6-14-y-old Ivorian children (n = 139) received iron-fortified biscuits, which contained 20 mg Fe/d, 4 times/wk as electrolytic iron or nonfortifoed biscuits. We measured changes in hemoglobin concentrations, inflammation, iron status, helminths, diarrhea, fecal calprotectin concentrations, and microbiota diversity and composition (n = 60) and the prevalence of selected enteropathogens. RESULTS: At baseline, there were greater numbers of fecal enterobacteria than of lactobacilli and bifidobacteria (P < 0.02). Iron fortification was ineffective; there were no differences in iron status, anemia, or hookworm prevalence at 6 mo. The fecal microbiota was modified by iron fortification as shown by a significant increase in profile dissimilarity (P < 0.0001) in the iron group as compared with the control group. There was a significant increase in the number of enterobacteria (P < 0.005) and a decrease in lactobacilli (P < 0.0001) in the iron group after 6 mo. In the iron group, there was an increase in the mean fecal calprotectin concentration (P < 0.01), which is a marker of gut inflammation, that correlated with the increase in fecal enterobacteria (P < 0.05). CONCLUSIONS: Anemic African children carry an unfavorable ratio of fecal enterobacteria to bifidobacteria and lactobacilli, which is increased by iron fortification. Thus, iron fortification in this population produces a potentially more pathogenic gut microbiota profile, and this profile is associated with increased gut inflammation. This trial was registered at controlled-trials.com as ISRCTN21782274
Dihydropyrimidine Accumulation Is Required for the Epithelial-Mesenchymal Transition
It is increasingly appreciated that oncogenic transformation alters cellular metabolism to facilitate cell proliferation, but less is known about the metabolic changes that promote cancer cell aggressiveness. Here, we analyzed metabolic gene expression in cancer cell lines and found that a set of high-grade carcinoma lines expressing mesenchymal markers share a unique 44 gene signature, designated the âmesenchymal metabolic signatureâ (MMS). A FACS-based shRNA screen identified several MMS genes as essential for the epithelial-mesenchymal transition (EMT), but not for cell proliferation. Dihydropyrimidine dehydrogenase (DPYD), a pyrimidine-degrading enzyme, was highly expressed upon EMT induction and was necessary for cells to acquire mesenchymal characteristics in vitro and for tumorigenic cells to extravasate into the mouse lung. This role of DPYD was mediated through its catalytic activity and enzymatic products, the dihydropyrimidines. Thus, we identify metabolic processes essential for the EMT, a program associated with the acquisition of metastatic and aggressive cancer cell traits.United States. National Institutes of Health (RO1 CA103866)United States. National Institutes of Health (AI047389)United States. National Institutes of Health (K99 CA168940)American Cancer Society (PF-12-099-01-TGB)American Cancer Society (PF-13-356-01-TBE)United States. Department of Defense (BC123066)United States. National Institutes of Health (CA112967)United States. National Institutes of Health (ES015339
The Rac1-GEF Tiam1 Couples the NMDA Receptor to the Activity-Dependent Development of Dendritic Arbors and Spines
NMDA-type glutamate receptors play a critical role in the activity-dependent development and structural remodeling of dendritic arbors and spines. However, the molecular mechanisms that link NMDA receptor activation to changes in dendritic morphology remain unclear. We report that the Rac1-GEF Tiam1 is present in dendrites and spines and is required for their development. Tiam1 interacts with the NMDA receptor and is phosphorylated in a calcium-dependent manner in response to NMDA receptor stimulation. Blockade of Tiam1 function with RNAi and dominant interfering mutants of Tiam1 suggests that Tiam1 mediates effects of the NMDA receptor on dendritic development by inducing Rac1-dependent actin remodeling and protein synthesis. Taken together, these findings define a molecular mechanism by which NMDA receptor signaling controls the growth and morphology of dendritic arbors and spines
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