Core CPI: excluding food, energy ... and used cars?

Although used car prices represent only a small portion of the consumer price index, their extreme volatility has had a major impact on the measured inflation rate. To explain this relationship, the authors describe how used cars are treated in the CPI and explore what might cause the wide swings in used car prices.Automobile industry and trade ; Consumer price indexes

Is Labor Green?

In this article, we assess whether unionization of national workforces influences growth in national carbon dioxide (CO2) emissions per capita. Political-economic theories in environmental sociology propose that labor unions have the potential to affect environmental conditions. Yet, few studies have quantitatively assessed the influence of unionization on environmental outcomes using cross-national data. We estimate multilevel regression models using data on OECD member nations from 1970 to 2014. Results from our analysis indicate that unionization, measured as the percentage of workers who are union members, is negatively associated with CO2 emissions per capita, even when controlling for labor conditions. This finding suggests that unionization may promote environmental protection at the national level

The Impact of baryonic physics on the kinetic Sunyaev-Zel'dovich Effect

Poorly understood "baryonic physics" impacts our ability to predict the power spectrum of the kinetic Sunyaev-Zel'dovich (kSZ) effect. We study this in one sample high resolution simulation of galaxy formation and feedback, Illustris. The high resolution of Illustris allows us to probe the kSZ power spectrum on multipoles $\ell =10^3-3\times 10^4$. Strong AGN feedback in Illustris nearly wipes out gas fluctuations at $k\gtrsim1~h~\rm{Mpc}^{-1}$ and at late times, likely somewhat under predicting the kSZ power generated at $z\lesssim 1$. The post-reionization kSZ power spectrum for Illustris is well-fit by $\mathcal{D}^{z<6}_{\ell} = 1.38[\ell/3000]^{0.21}~\mu K^2$ over $3000\lesssim\ell\lesssim10000$, somewhat lower than most other reported values but consistent with the analysis of Shaw et al. Our analysis of the bias of free electrons reveals subtle effects associated with the multi-phase gas physics and stellar fractions that affect even linear scales. In particular there are fewer electrons in biased galaxies, due to gas cooling and star formation, and this leads to an electron bias less than one even at low wavenumbers. The combination of bias and electron fraction that determines the overall suppression is relatively constant, $f_e^2b^2_{e0} \sim 0.7$, but more simulations are needed to see if this is Illustris-specific. By separating the kSZ power into different terms, we find at least $6\, (10)\%$ of the signal at $\ell=3000\, (10000)$ comes from non-Gaussian connected four-point density and velocity correlations, \left_{c}, even without correcting for the Illustris simulation box size. A challenge going forward will be to accurately model long-wave velocity modes simultaneously with Illustris-like high resolution to capture the complexities of galaxy formation and its correlations with large scale flows.Comment: 12 pages, 9 figure, submitted to Ap

Muscarinic receptor oligomerization

G protein-coupled receptors (GPCRs) have been classically described as monomeric entities that function by binding in a 1:1 stoichiometric ratio to both ligand and downstream signalling proteins. However, in recent years, a growing number of studies has supported the hypothesis that these receptors can interact to form dimers and higher order oligomers although the molecular basis for these interactions, the overall quaternary arrangements and the functional importance of GPCR oligomerization remain topics of intense speculation. Muscarinic acetylcholine receptors belong to class A of the GPCR family. Each muscarinic receptor subtype has its own particular distribution throughout the central and peripheral nervous systems. In the central nervous system, muscarinic receptors regulate several sensory, cognitive, and motor functions while, in the peripheral nervous system, they are involved in the regulation of heart rate, stimulation of glandular secretion and smooth muscle contraction. Muscarinic acetylcholine receptors have long been used as a model for the study of GPCR structure and function and to address aspects of GPCR dimerization using a broad range of approaches. In this review, the prevailing knowledge regarding the quaternary arrangement for the various muscarinic acetylcholine receptors has been summarized by discussing work ranging from initial results obtained using more traditional biochemical approaches to those generated with more modern biophysical techniques

Ligand regulation of the quaternary organization of cell surface M3 muscarinic acetylcholine receptors analyzed by fluorescence resonance energy transfer (FRET) imaging and homogenous time-resolved FRET

Flp-In T-REx 293 cells expressing a wild type human M muscarinic acetylcholine receptor construct constitutively and able to express a Receptor Activated Solely by Synthetic Ligand (RASSL) form of this receptor on demand maintained response to the muscarinic agonist carbachol but developed response to clozapine-N-oxide only upon induction of the RASSL. The two constructs co-localized at the plasma membrane and generated strong ratiometric fluorescence resonance energy transfer (FRET) signals consistent with direct physical interactions. Increasing levels of induction of the FRET-donor RASSL did not alter wild type receptor FRET-acceptor levels substantially. However, ratiometric FRET was modulated in a bell-shaped fashion with maximal levels of the donor resulting in decreased FRET. Carbachol, but not the antagonist atropine, significantly reduced the FRET signal. Cell surface homogenous time-resolved FRET, based on SNAP-tag technology and employing wild type and RASSL forms of the human M receptor expressed stably in Flp-In TREx 293 cells, also identified cell surface dimeric/oligomeric complexes. Now, however, signals were enhanced by appropriate selective agonists. At the wild type receptor large increases in FRET signal to carbachol and acetylcholine were concentration-dependent with EC values consistent with the relative affinities of the two ligands. These studies confirm the capacity of the human M muscarinic acetylcholine receptor to exist as dimeric/oligomeric complexes at the surface of cells and demonstrate that the organization of such complexes can be modified by ligand binding. However, conclusions as to the effect of ligands on such complexes may depend on the approach used

The promise of e-Health – a Canadian perspective

Canadians value their health care system above any other social program. Canada's system of health care faces significant financial and population pressures, relating to cost, access, quality, accountability, and the integration of information and communication technologies (ICTs). The health-system also faces certain unique challenges that include care delivery within a highly decentralised system of financing and accountability, and care delivery to a significant portion of the population sparsely distributed across a landmass of 10 million square kilometres, in areas of extreme climatic conditions. All of these challenges are significant catalysts in the development of technologies that aim to significantly mitigate or eliminate these selfsame challenges. The system is undergoing widespread review, nationally, and within each province and territory, where the bulk of care provision is financed and managed. The challenges are being addressed by national, regional and provincial initiatives in the public, private and not-for-profit sectors. The promise of e-Health lies in the manner and degree to which it can mitigate or resolve these challenges to the health system and build on advancements in ICTs supporting the development of a health infostructure. Canada is actively developing and implementing technological solutions to deliver health information and health care services across the country. These solutions, while exciting and promising, also present new challenges, particularly in regard to acceptable standards, choice of technologies, overcoming traditional jurisdictional boundaries, up-front investment, and privacy and confidentially. Many organisations and governments are working to address these challenges. The Canadian Institute for Health Information (CIHI) will play an increasingly significant role in these initiatives, as the management of health information becomes a more crucial factor in the successful delivery of health care services in the new millennium

Climate Change Policy: The Waxman-Markey Bill

The Waxman-Markey Bill is a comprehensive national climate and energy legislation designed to reduce global warming pollution and transition to a clean energy economy. In order to accomplish the first goal, the bill introduces a cap-and-trade program