44 research outputs found

    Willpower Satisficing

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    Satisficing Consequentialism is often rejected as hopeless. Perhaps its greatest problem is that it risks condoning the gratuitous prevention of goodness above the baseline of what qualifies as “good enough”. I propose a radical new willpower-based version of the view that avoids this problem, and that better fits with the motivation of avoiding an excessively demanding conception of morality. I further demonstrate how, by drawing on the resources of an independent theory of blameworthiness, we may obtain a principled specification of what counts as “good enough”

    Influenza Infectious Dose May Explain the High Mortality of the Second and Third Wave of 1918–1919 Influenza Pandemic

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    BACKGROUND: It is widely accepted that the shift in case-fatality rate between waves during the 1918 influenza pandemic was due to a genetic change in the virus. In animal models, the infectious dose of influenza A virus was associated to the severity of disease which lead us to propose a new hypothesis. We propose that the increase in the case-fatality rate can be explained by the dynamics of disease and by a dose-dependent response mediated by the number of simultaneous contacts a susceptible person has with infectious ones. METHODS: We used a compartment model with seasonality, waning of immunity and a Holling type II function, to model simultaneous contacts between a susceptible person and infectious ones. In the model, infected persons having mild or severe illness depend both on the proportion of infectious persons in the population and on the level of simultaneous contacts between a susceptible and infectious persons. We further allowed for a high or low rate of waning immunity and volunteer isolation at different times of the epidemic. RESULTS: In all scenarios, case-fatality rate was low during the first wave (Spring) due to a decrease in the effective reproduction number. The case-fatality rate in the second wave (Autumn) depended on the ratio between the number of severe cases to the number of mild cases since, for each 1000 mild infections only 4 deaths occurred whereas for 1000 severe infections there were 20 deaths. A third wave (late Winter) was dependent on the rate for waning immunity or on the introduction of new susceptible persons in the community. If a group of persons became voluntarily isolated and returned to the community some days latter, new waves occurred. For a fixed number of infected persons the overall case-fatality rate decreased as the number of waves increased. This is explained by the lower proportion of infectious individuals in each wave that prevented an increase in the number of severe infections and thus of the case-fatality rate. CONCLUSION: The increase on the proportion of infectious persons as a proxy for the increase of the infectious dose a susceptible person is exposed, as the epidemic develops, can explain the shift in case-fatality rate between waves during the 1918 influenza pandemic.TD acknowledges the support of the Faculdade de Ciencias e Tecnologia through grant PPCDT/AMB/55701/2004. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript

    Combustion

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    Combustion

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    Metal-based nanoenergetic materials: Synthesis, properties, and applications

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    Metal particles are attractive candidate fuels for various propulsion and energy-conversion applications, primarily due to their high energy densities. Micron-sized particles present several drawbacks, such as high ignition temperatures and particle agglomeration, resulting in low energy-release rates. Nanoparticles, on the other hand, are quite attractive due to their unique and favorable properties, which are attributed to their high specific surface area and excess energy of surface atoms. As a result, there is a growing interest in employing metal nanoparticles in propulsion and energy-conversion systems. The present work provides a comprehensive review of the advances made over the past few decades in the areas of synthesis, properties, and applications of metal-based energetic nanomaterials. An overview of existing methods to synthesize nanomaterials is first provided. Novel approaches to passivate metal nanoparticles are also discussed. The physicochemical properties of metal nanoparticles are then examined in detail. Low-temperature oxidation processes, and ignition and combustion of metal nanoparticles are investigated. The burning behaviors of different energetic material formulations with metal nanoparticles such as particle-laden dust clouds, solid propellants, liquid fuels and propellants, thermite materials, and inter-metallic systems are reviewed. Finally, deficiencies and uncertainties in our understanding of the field are identified, and directions for future work are suggested.by Dilip Sundaram, Vigor Yang and Richard A. Yette
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