Integrated Models of Care for Individuals with Opioid Use Disorder: How Do We Prevent HIV and HCV?

Purpose of Review To describe models of integrated and co-located care for opioid use disorder (OUD), hepatitis C (HCV), and HIV. Recent Findings The design and scale-up of multidisciplinary care models that engage, retain, and treat individuals with HIV, HCV, and OUD are critical to preventing continued spread of HIV and HCV. We identified 17 models within primary care (N = 3), HIV specialty care (N = 5), opioid treatment programs (N = 6), transitional clinics (N = 2), and community-based harm reduction programs (N = 1), as well as two emerging models. Summary Key components of such models are the provision of (1) medication-assisted treatment for OUD, (2) HIV and HCV treatment, (3) HIV pre-exposure prophylaxis, and (4) behavioral health services. Research is needed to understand differences in effectiveness between co-located and fully integrated care, combat the deleterious racial and ethnic legacies of the “War on Drugs,” and inform the delivery of psychiatric care. Increased access to harm reduction services is crucial

Shocked POststarbust Galaxy Survey I: Candidate Poststarbust Galaxies with Emission Line Ratios Consistent with Shocks

[Abridged] The Shocked POststarburst Galaxy Survey (SPOGS) aims to identify transforming galaxies, in which the nebular lines are excited via shocks instead of through star formation processes. Utilizing the OSSY measurements on the Sloan Digital Sky Survey Data Release 7 catalog, we applied Balmer absorption and shock boundary criteria to identify 1,067 SPOG candidates (SPOGs*) within z=0.2. SPOGs* represent 0.2% of the OSSY sample galaxies that exceed the continuum signal-to-noise cut (and 0.7% of the emission line galaxy sample). SPOGs* colors suggest that they are in an earlier phase of transition than OSSY galaxies that meet an E+A selection. SPOGs* have a 13% 1.4GHz detection rate from the Faint Images of the Radio Sky at Twenty centimeters survey, higher than most other subsamples, and comparable only to low-ionization nuclear emission line region hosts, suggestive of the presence of active galactic nuclei. SPOGs* also have stronger NaD absorption than predicted from the stellar population, suggestive of cool gas being driven out in galactic winds. It appears that SPOGs* represent an earlier phase in galaxy transformation than traditionally selected poststarburst galaxies, and that a large proportion of SPOGs* also have properties consistent with disruption of their interstellar media, a key component to galaxy transformation. It is likely that many of the known pathways to transformation undergo a SPOG phase. Studying this sample of SPOGs* further, including their morphologies, active galactic nuclei properties, and environments, has the potential for us to build a more complete picture of the initial conditions that can lead to a galaxy evolving.Comment: 19 pages, 19 figures, 3 tables, accepted to ApJ Supplements (Apr 13), full sample is available on www.spogs.or

Proper Motions in the Galactic Bulge: Plaut's Window

A proper motion study of a field of 20' x 20' inside Plaut's low extinction window (l,b)=(0 deg,-8 deg), has been completed. Relative proper motions and photographic BV photometry have been derived for ~21,000 stars reaching to V~20.5 mag, based on the astrometric reduction of 43 photographic plates, spanning over 21 years of epoch difference. Proper motion errors are typically 1 mas/yr and field dependent systematics are below 0.2 mas/yr. Cross-referencing with the 2MASS catalog yielded a sample of ~8,700 stars, from which predominantly disk and bulge subsamples were selected photometrically from the JH color-magnitude diagram. The two samples exhibited different proper-motion distributions, with the disk displaying the expected reflex solar motion as a function of magnitude. Galactic rotation was also detected for stars between ~2 and ~3 kpc from us. The bulge sample, represented by red giants, has an intrinsic proper motion dispersion of (sigma_l,sigma_b)=(3.39, 2.91)+/-(0.11,0.09) mas/yr, which is in good agreement with previous results, and indicates a velocity anisotropy consistent with either rotational broadening or tri-axiality. A mean distance of 6.37^{+0.87}_{-0.77} kpc has been estimated for the bulge sample, based on the observed K magnitude of the horizontal branch red clump. The metallicity [M/H] distribution was also obtained for a subsample of 60 bulge giants stars, based on calibrated photometric indices. The observed [M/H] shows a peak value at [M/H]~-0.1 with an extended metal poor tail and around 30% of the stars with supersolar metallicity. No change in proper motion dispersion was observed as a function of [M/H]. We are currently in the process of obtaining CCD UBVRI photometry for the entire proper-motion sample of ~21,000 stars.Comment: Submitted to AJ April 17th 2007. Accepted June 8th 2007. 45 pages, 14 figure

SHOCKED POSTSTARBURST GALAXY SURVEY. II. the MOLECULAR GAS CONTENT and PROPERTIES of A SUBSET of SPOGs

We present CO(1–0) observations of objects within the Shocked POststarburst Galaxy Survey taken with the Institut de Radioastronomie Millimétrique 30 m single dish and the Combined Array for Research for Millimeter Astronomy interferometer. Shocked poststarburst galaxies (SPOGs) represent a transitioning population of galaxies, with deep Balmer absorption $({\mathrm{EW}}_{{\rm{H}}\delta }\gt 5\,{\mathring{\rm{A}}} )$, consistent with an intermediate-age (A-star) stellar population, and ionized gas line ratios inconsistent with pure star formation. The CO(1–0) subsample was selected from SPOGs detected by the Wide-field Infrared Survey Explorer with 22 μm flux detected at a signal-to-noise ratio (S/N) > 3. Of the 52 objects observed in CO(1–0), 47 are detected with S/N > 3. A large fraction (37%–46% ± 7%) of our CO-SPOG sample were visually classified as morphologically disrupted. The H2 masses detected were between ${10}^{8.7-10.8}$ ${M}_{\odot }$, consistent with the gas masses found in normal galaxies, though approximately an order of magnitude larger than the range seen in poststarburst galaxies. When comparing the 22 μm and CO(1–0) fluxes, SPOGs diverge from the normal star-forming relation, having 22 μm fluxes in excess of the relation by a factor of $\langle {\epsilon }_{{\rm{MIR}}}\rangle ={4.91}_{-0.39}^{+0.42}$, suggestive of the presence of active galactic nuclei (AGNs). The Na i D characteristics of CO-SPOGs show that it is likely that many of these objects host interstellar winds. Objects with large Na i D enhancements also tend to emit in the radio, suggesting possible AGN driving of neutral winds

Analysis of Neptune's 2017 Bright Equatorial Storm

We report the discovery of a large ($\sim$8500 km diameter) infrared-bright storm at Neptune's equator in June 2017. We tracked the storm over a period of 7 months with high-cadence infrared snapshot imaging, carried out on 14 nights at the 10 meter Keck II telescope and 17 nights at the Shane 120 inch reflector at Lick Observatory. The cloud feature was larger and more persistent than any equatorial clouds seen before on Neptune, remaining intermittently active from at least 10 June to 31 December 2017. Our Keck and Lick observations were augmented by very high-cadence images from the amateur community, which permitted the determination of accurate drift rates for the cloud feature. Its zonal drift speed was variable from 10 June to at least 25 July, but remained a constant $237.4 \pm 0.2$ m s$^{-1}$ from 30 September until at least 15 November. The pressure of the cloud top was determined from radiative transfer calculations to be 0.3-0.6 bar; this value remained constant over the course of the observations. Multiple cloud break-up events, in which a bright cloud band wrapped around Neptune's equator, were observed over the course of our observations. No "dark spot" vortices were seen near the equator in HST imaging on 6 and 7 October. The size and pressure of the storm are consistent with moist convection or a planetary-scale wave as the energy source of convective upwelling, but more modeling is required to determine the driver of this equatorial disturbance as well as the triggers for and dynamics of the observed cloud break-up events.Comment: 42 pages, 14 figures, 6 tables; Accepted to Icaru

Interventions aimed at increasing research use in nursing: a systematic review

<p>Abstract</p> <p>Background</p> <p>There has been considerable interest recently in developing and evaluating interventions to increase research use by clinicians. However, most work has focused on medical practices; and nursing is not well represented in existing systematic reviews. The purpose of this article is to report findings from a systematic review of interventions aimed at increasing research use in nursing.</p> <p>Objective</p> <p>To assess the evidence on interventions aimed at increasing research use in nursing.</p> <p>Methods</p> <p>A systematic review of research use in nursing was conducted using databases (Medline, CINAHL, Healthstar, ERIC, Cochrane Central Register of Controlled Trials, and Psychinfo), grey literature, ancestry searching (Cochrane Database of Systematic Reviews), key informants, and manual searching of journals. Randomized controlled trials and controlled before- and after-studies were included if they included nurses, if the intervention was explicitly aimed at increasing research use or evidence-based practice, and if there was an explicit outcome to research use. Methodological quality was assessed using pre-existing tools. Data on interventions and outcomes were extracted and categorized using a pre-established taxonomy.</p> <p>Results</p> <p>Over 8,000 titles were screened. Three randomized controlled trials and one controlled before- and after-study met the inclusion criteria. The methodological quality of included studies was generally low. Three investigators evaluated single interventions. The most common intervention was education. Investigators measured research use using a combination of surveys (three studies) and compliance with guidelines (one study). Researcher-led educational meetings were ineffective in two studies. Educational meetings led by a local opinion leader (one study) and the formation of multidisciplinary committees (one study) were both effective at increasing research use.</p> <p>Conclusion</p> <p>Little is known about how to increase research use in nursing, and the evidence to support or refute specific interventions is inconclusive. To advance the field, we recommend that investigators: (1) use theoretically informed interventions to increase research use, (2) measure research use longitudinally using theoretically informed and psychometrically sound measures of research use, as well as, measuring patient outcomes relevant to the intervention, and (3) use more robust and methodologically sound study designs to evaluate interventions. If investigators aim to establish a link between using research and improved patient outcomes they must first identify those interventions that are effective at increasing research use.</p

Extragalactic Star Cluster Science with the Nancy Grace Roman Space Telescope's High Latitude Wide Area Survey and the Vera C. Rubin Observatory

The Nancy Grace Roman Telescope's High Latitude Wide Area Survey will have a number of synergies with the Vera Rubin Observatory's Legacy Survey of Space and Time (LSST), particularly for extragalactic star clusters. Understanding the nature of star clusters and star cluster systems are key topics in many areas of astronomy, chief among them stellar evolution, high energy astrophysics, galaxy assembly/dark matter, the extragalactic distance scale, and cosmology. One of the challenges will be disentangling the age/metallicity degeneracy because young ($\sim$Myr) metal-rich clusters have similar SEDs to old ($\sim$Gyr) metal-poor clusters. Rubin will provide homogeneous, $ugrizy$ photometric coverage, and measurements in the red Roman filters will help break the age-metallicity and age-extinction degeneracies, providing the first globular cluster samples that cover wide areas while essentially free of contamination from Milky Way stars. Roman's excellent spatial resolution will also allow measurements of cluster sizes. We advocate for observations of a large sample of galaxies with a range of properties and morphologies in the Rubin/LSST footprint matching the depth of the LSST Wide-Fast-Deep field $i$ band limit (26.3 mag), and recommend adding the F213 filter to the survey.Comment: white paper submitted for Roman CCS inpu