Macrophage-sensory neuronal interaction in HIV-1 gp120-induced neurotoxicity

Acknowledgements We thank Dr Jim Perkins of University College London for his help with the statistical analysis of our gene array data. We thank Prof. Maria Papathanasopoulos from the University of the Witwatersrand, Johannesburg, for the gift of gp120Bal.Peer reviewedPublisher PD

Astrometric signatures of self-gravitating protoplanetary discs

We use high resolution numerical simulations to study whether gravitational instabilities within circumstellar discs can produce astrometrically detectable motion of the central star. For discs with masses of M_disc = 0.1 M_star, which are permanantly stable against fragmentation, we find that the magnitude of the astrometric signal depends upon the efficiency of disc cooling. Short cooling times produce prominent filamentary spiral structures in the disc, and lead to stellar motions that are potentially observable with future high precision astrometric experiments. For a disc that is marginally unstable within radii of \~10 au, we estimate astrometric displacements of 10-100 microarcsec on decade timescales for a star at a distance of 100 pc. The predicted displacement is suppressed by a factor of several in more stable discs in which the cooling time exceeds the local dynamical time by an order of magnitude. We find that the largest contribution comes from material in the outer regions of the disc and hence, in the most pessimistic scenario, the stellar motions caused by the disc could confuse astrometric searches for low mass planets orbiting at large radii. They are, however, unlikely to present any complications in searches for embedded planets orbiting at small radii, relative to the disc size, or Jupiter mass planets or greater orbiting at large radii.Comment: 6 pages, 9 figures, accepted for publication in MNRA

Zeeman splittings of the 5D0–7F2 transitions of Eu3+ ions implanted into GaN

We report the magnetic field splittings of emission lines assigned to the 5D0–7F2 transitions of Eu3+ centres in GaN. The application of a magnetic field in the c-axis direction (B||c) leads to a splitting of the major lines at 621 nm, 622 nm and 622.8 nm into two components. The Zeeman splitting is linear with magnetic field up to 5 Tesla for each line. In contrast, a magnetic field applied in the growth plane (B┴c) does not influence the photoluminescence spectra. The estimated g-factors vary slightly from sample to sample with mean values of g|| ~2.8, ~1.5 and ~2.0 for the emission lines at 621 nm, 622 nm and 622.8 nm respectively

Enhanced Coherence of Antinodal Quasiparticles in a Dirty d-wave Superconductor

Recent ARPES experiments show a narrow quasiparticle peak at the gap edge along the antinodal [1,0]-direction for the overdoped cuprate superconductors. We show that within weak coupling BCS theory for a d-wave superconductor the s-wave single-impurity scattering cross section vanishes for energies of the gap edge. This coherence effect occurs through multiple scattering off the impurity. For small impurity concentrations the spectral function has a pronounced increase of the (scattering) lifetime for antinodal quasiparticles but shows a very broad peak in the nodal direction, in qualitative agreement with experiment and in strong contrast to the behavior observed in underdoped cuprates.Comment: 4 pages, 3 figures, submitte

Planetesimal Formation In Self-Gravitating Discs

We study particle dynamics in local two-dimensional simulations of self-gravitating accretion discs with a simple cooling law. It is well known that the structure which arises in the gaseous component of the disc due to a gravitational instability can have a significant effect on the evolution of dust particles. Previous results using global simulations indicate that spiral density waves are highly efficient at collecting dust particles, creating significant local over-densities which may be able to undergo gravitational collapse. We expand on these findings, using a range of cooling times to mimic the conditions at a large range of radii within the disc. Here we use the Pencil Code to solve the 2D local shearing sheet equations for gas on a fixed grid together with the equations of motion for solids coupled to the gas solely through aerodynamic drag force. We find that spiral density waves can create significant enhancements in the surface density of solids, equivalent to 1-10cm sized particles in a disc following the profiles of Clarke (2009) around a solar mass star, causing it to reach concentrations several orders of magnitude larger than the particles mean surface density. We also study the velocity dispersion of the particles, finding that the spiral structure can result in the particle velocities becoming highly ordered, having a narrow velocity dispersion. This implies low relative velocities between particles, which in turn suggests that collisions are typically low energy, lessening the likelihood of grain destruction. Both these findings suggest that the density waves that arise due to gravitational instabilities in the early stages of star formation provide excellent sites for the formation of large, planetesimal-sized objects.Comment: 11 pages, 8 figures, accepted for publication in MNRA

Convergence of SPH simulations of self-gravitating accretion discs: Sensitivity to the implementation of radiative cooling

Recent simulations of self-gravitating accretion discs, carried out using a three-dimensional Smoothed Particle Hydrodynamics (SPH) code by Meru and Bate, have been interpreted as implying that three-dimensional global discs fragment much more easily than would be expected from a two-dimensional local model. Subsequently, global and local two-dimensional models have been shown to display similar fragmentation properties, leaving it unclear whether the three-dimensional results reflect a physical effect or a numerical problem associated with the treatment of cooling or artificial viscosity in SPH. Here, we study how fragmentation of self-gravitating disc flows in SPH depends upon the implementation of cooling. We run disc simulations that compare a simple cooling scheme, in which each particle loses energy based upon its internal energy per unit mass, with a method in which the cooling is derived from a smoothed internal energy density field. For the simple per particle cooling scheme, we find a significant increase in the minimum cooling time scale for fragmentation with increasing resolution, matching previous results. Switching to smoothed cooling, however, results in lower critical cooling time scales, and tentative evidence for convergence at the highest spatial resolution tested. We conclude that precision studies of fragmentation using SPH require careful consideration of how cooling (and, probably, artificial viscosity) is implemented, and that the apparent non-convergence of the fragmentation boundary seen in prior simulations is likely a numerical effect. In real discs, where cooling is physically smoothed by radiative transfer effects, the fragmentation boundary is probably displaced from the two-dimensional value by a factor that is only of the order of unity.Comment: 9 pages, 11 figures, MNRAS in pres

Optimal Control of Quantum Dynamics : A New Theoretical Approach

A New theoretical formalism for the optimal quantum control has been presented. The approach stems from the consideration of describing the time-dependent quantum system in terms of the real physical observables, viz., the probability density rho(x,t) and the quantum current j(x,t) which is well documented in the Bohm's hydrodynamical formulation of quantum mechanics. The approach has been applied for manipulating the vibrational motion of HBr in its ground electronic state under an external electric field.Comment: 4 figure

Quasiparticles in the Pseudogap Phase of Underdoped Cuprate

Recent angle resolved photoemission \cite{yang-nature-08} and scanning tunneling microscopy \cite{kohsaka-nature-08} measurements on underdoped cuprates have yielded new spectroscopic information on quasiparticles in the pseudogap phase. New features of the normal state such as particle-hole asymmetry, maxima in the energy dispersion and accompanying drops in the spectral weight of quasiparticles agree with the ansatz of Yang \textit{et al.} for the single particle propagator in the pseudogap phase. The coherent quasiparticle dispersion and reduced asymmetry in the tunneling density of states in the superconducting state can also be described by this propagator.Comment: updated version, 6 pages, 7 figures, 1 table, EPL 86 (2009) 37002 (https://www.epletters.net