Current Pathophysiological and Genetic Aspects of Dilated Cardiomyopathy

Dilated cardiomyopathy is the most common form of cardiomyopathy and the second leading cause of left ventricular dysfunction with highly variable clinical presentation and prognosis. The clinical courses vary and are strongly heterogeneous, ranging from asymptomatic patients to those suffering from intractable heart failure or sudden cardiac death due to arrhythmias. Previous studies have reported a 10 years cardiovascular mortality up to 40% in developed countries, due to advanced heart failure or sudden cardiac death. However, the prognosis of dilated cardiomyopathy patients is variable and depends on multiple risk factors. This chapter provides a review of dilated cardiomyopathy with specific focus on the pathophysiological aspects and genetic etiology of the disease

Measurement of the W boson mass

International audienceThe W boson mass is measured using proton-proton collision data at $\sqrt{s}$ = 13 TeV corresponding to an integrated luminosity of 1.7 fb$^{−1}$ recorded during 2016 by the LHCb experiment. With a simultaneous fit of the muon q/p$_{T}$ distribution of a sample of W → μν decays and the ϕ$^{*}$ distribution of a sample of Z → μμ decays the W boson mass is determined to be${m}_w=80354\pm {23}_{\mathrm{stat}}\pm {10}_{\mathrm{exp}}\pm {17}_{\mathrm{theory}}\pm {9}_{\mathrm{PDF}}\mathrm{MeV},$where uncertainties correspond to contributions from statistical, experimental systematic, theoretical and parton distribution function sources. This is an average of results based on three recent global parton distribution function sets. The measurement agrees well with the prediction of the global electroweak fit and with previous measurements.[graphic not available: see fulltext