13 research outputs found

    An investigation into CLIL-related sections of EFL coursebooks : issues of CLIL inclusion in the publishing market

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    The current ELT global coursebook market has embraced CLIL as a weak form of bilingual education and an innovative component to include in General English coursebooks for EFL contexts. In this paper I investigate how CLIL is included in ELT coursebooks aimed at teenaged learners, available to teachers in Argentina. My study is based on the content analysis of four series which include a section advertised as CLIL-oriented. Results suggest that such sections are characterised by (1) little correlation between featured subject specific content and school curricula in L1, (2) oversimplification of contents, and (3) dominance of reading skills development and lower-order thinking tasks. Through this study, I argue that CLIL components become superficial supplements rather than a meaningful attempt to promote weak forms of bilingual education

    The Use of the Diagnostic Criteria for Psychosomatic Research in Substance Use Disorder Patients

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    Chaturvedi and Goswami have reported on the useful clinical information that may derive from the use of the Diagnostic Criteria for Psychosomatic Research (DCPR) in a psychiatric setting. It has also been widely accepted that DCPR, being based on a clinimetric approach, allows a more sophisticated qualitative assessment of patients than the dimensional DSM checklist of symptoms. This means that DCPR measures symptoms, physical signs, and other clinical phenomena (e.g. type, severity and sequence of symptoms) and, as suggested by macroanalysis, it diagnoses syndromes and/or disorders that can be organized according to a hierarchical configuration on the basis of where treatment should commence in the first place. Recently, macroanalysis has been proposed for the assessment of substance use disorder (SUD) subjects, and DCPR has been hypothesized as possible predictors of cooccurrent psychiatric disorders in such a clinical population. In this framework, we used both DSM-IV and DCPR criteria in a sample of substance abuse outpatients to verify if DCPR might expand the psychological assessment in SUD settings

    Determining the genes responsible for drug resistance in ovarian and breast cancer stem cells

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    The majority of deaths in ovarian and breast cancer are caused by recurrent metastatic disease which is usually multidrug resistant. This progression has been hypothesised to be due in part to the presence of cancer stem cells, a subset of cells which are capable of self renewal and are able to survive chemotherapy and migrate to distant sites. Side population (SP) cells, identified by the efflux of the DNA binding dye Hoechst 33342 through ABC transporters, are a known adult stem cell group and have been suggested as a cancer stem cell in various cancers. The aims of this study were (i) to determine the presence and prevalence of SP cells in ovarian and breast cancer cell lines and clinical samples, and (ii) to ascertain their role both as cancer stem cells and in cancer drug resistance through ABC transporter identification and specific transporter knockdown. SP cells were identified in both ovarian and breast cancer cell lines and clinical samples. These SP cells expressed known stem cell genes and exhibited stem cell characteristics. SP cells in both ovarian and breast cancer cell lines were more drug resistant than non- SP (NSP, bulk tumour cells), and furthermore this drug resistance was shown to be due to expression of different ABC transporters in different tissue specific cancers. ABCG2 was found to be the predominate transporter expressed in breast cancer cell line derived SP populations, however silencing ABCG2 in MCF-7 breast cancer cell SP did not either completely inhibit SP presence or increase cell sensitivity to chemotherapy. In contrast ABCB1 was the predominant transporter expressed in ovarian cancer cell line (IGROV1 and HeyA8MDR) derived SP cells and silencing this transporter both fully inhibited SP cells and significantly increased SP cell death following treatment with paclitaxel. In clinical samples, the presence of SP cells in fine needle aspirates from breast cancer patients correlated to oestrogen receptor negative disease and the triple negative phenotype (ER-,PR-,HER2-), a marker of poor patient prognosis. This study has provided evidence of a role for SP cells in both breast and ovarian cancer. SP cells have a possible prognostic role in breast cancer, and ABCB1 should be considered as a therapeutic target in ovarian cancer.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

    Lingue europee nella scuola dell'infanzia

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    include, di P. E. Balboni: "Lingue europee nella scuola dell'infanzia", pp. 1-2

    La valutazione: strumenti e risultati

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    Newspaper published in Holland, Michigan, from 1872-1977, to serve the English-speaking people in Holland, Michigan. Purchased by local Dutch language newspaper, De Grondwet, owner in 1888.https://digitalcommons.hope.edu/hcn_1901/1044/thumbnail.jp

    La valutazione: strumenti e risultati

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    Lingue europee nella scuola dell'infanzia

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    include, di P. E. Balboni: "Lingue europee nella scuola dell'infanzia", pp. 1-2
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