Contribution to the study of the central regulation of food intake and of the metabolic alterations in obesity

BV UNIFESP: Teses e dissertaçõe

Papel dos hormônios adrenais na contrarregulação da hipoglicemia insulínica em ratos

BV UNIFESP: Teses e dissertaçõe

Efeito do jejum em ratos com obesidade induzida pelo glutamato monossódico

BV UNIFESP: Teses e dissertaçõe

Plasma levels of acylated and total ghrelin in pediatric patients with chronic kidney disease

This cross-sectional study set out to compare total and acyl ghrelin levels in children with mild chronic kidney disease (CKD) undergoing conservative treatment (n = 19) with children with end-stage renal disease (ESRD) undergoing hemodialysis (n = 24), and with healthy controls (n = 20). the relationship between ghrelin levels and parameters of renal function, nutritional status, and selective hormones were investigated. ESRD patients had higher total ghrelin levels than those with mild CKD or control individuals. However, acyl ghrelin did not differ between groups, indicating that the excess circulating ghrelin was desacylated. Since desacyl ghrelin has been shown to inhibit appetite, increased levels might contribute to protein-energy wasting in pediatric renal patients. When all 43 renal patients were combined, multiple regression analysis found age and glomerular filtration rate (GFR) to be significant negative predictors of total ghrelin. Acyl ghrelin was influenced negatively by age and positively by energy intake. Acyl to total ghrelin ratio related positively to GFR and energy intake. the results indicate that total but not acyl ghrelin is influenced by low GFR in children with CKD and suggests that ghrelin activation may be impaired in these patients. Since energy intake is a positive predictor of acyl ghrelin, the physiological control of ghrelin secretion appears to be altered in pediatric renal patients.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Universidade Federal de São Paulo, Postgrad Program Pediat, BR-01417010 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Physiol, BR-01417010 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Pediat, BR-01417010 São Paulo, BrazilUniversidade Federal de São Paulo, Postgrad Program Pediat, BR-01417010 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Physiol, BR-01417010 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Pediat, BR-01417010 São Paulo, BrazilWeb of Scienc

Lipid metabolism of monosodium glutamate obese rats after partial removal of adipose tissue

We analyzed the effects of partial fat pad removal on retroperitoneal and epididymal fat depots and carcass metabolism of control (C) and MSG-obese (M) rats. Three-month-old C and M male Wistar rats were submitted to either partial surgical excision of epididymal and retroperitoneal fat tissue (lipectomy, Q or sham surgery (S) and studied after 7 or 30 days. Retroperitoneal and epididymal tissue re-growth after lipectomy was not observed, as indicated by the low pads weight of the L groups. The lipolysis rate was stimulated in LC7 and LM7, probably due to surgical stress and low insulin levels. In LM7, but not in LC7, in vivo lipogenesis rate increased in retroperitoneal and epididymal fat tissue, as did the diet-derived lipid accumulation in epididymal fat tissue. Although these local increases were no longer present in LM30, this group showed a large increase in the percentage of small area adipocytes in both pads as well as increased carcass lipogenesis rate. The present data showed that the partial removal of fat depots affected the metabolism of control and MSG-obese rats differently. In the obese animals only, it stimulated both local and carcass lipogenesis rate as well as adipocyte differentiation, i.e. responses likely to favor excised tissue re-growth and/or compensatory growth of non-excised depots.Univ Fed Sao Paulo, Dept Fisiol, BR-04023060 Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Fisiol, BR-04023060 Sao Paulo, BrazilWeb of Scienc

Modulares Mikroreaktorsystem aus ultraschallheißgeprägten Polymerfolien

Functional foods containing bioactive compounds of whey may play an important role in prevention and treatment of obesity. the aim of this study was to investigate the prospects of the biotechnological process of coacervation of whey proteins (CWP) in chitosan and test its antiobesogenic potential. Methods. CWP (100mg.kg.day) was administered in mice with diet-induced obesity for 8 weeks. the animals were divided into four groups: control normocaloric diet gavage with water (C) or coacervate (C-CWP), and high fat diet gavage with water (HF) or coacervate (HF-CWP). Results. HF-CWP reduced weight gain and serum lipid fractions and displayed reduced adiposity and insulin. Adiponectin was significantly higher in HF-CWP group when compared to the HF. the level of LPS in HF-W group was significantly higher when compared to HF-CWP. the IL-10 showed an inverse correlation between the levels of insulin and glucose in the mesenteric adipose tissue in the HF-CWP group. CWP promoted an increase in both phosphorylation AMPK and the amount of ATGL in the mesenteric adipose tissue in HF-CWP group. Conclusion. CWP was able to modulate effects, possibly due to its high biological value of proteins. We observed a protective effect against obesity and improved the inflammatory milieu of white adipose tissue