149 research outputs found

    Sections 3 and 4 of the Human Rights Act and their impact on the United Kingdom’s constitutional arrangements

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    In the late 1990s, the Human Rights Act 1998 (HRA) was incorporated into British law. Section 3 of the HRA grants British judges to go as far as they can when interpreting domestic legislation in line with the European Convention on Human Rights. This article reviews relevant case law to assert that despite this extension of judicial power, British judges interpret domestic legislation in line with its fundamental purpose when reviewing whether it is compliant with the European Convention on Human Rights. This article also considers the impact of section 4 of the HRA on the UK’s constitutional arrangements. Section 4 allows judges to issue a ‘declaration of incompatibility’ upon finding domestic legislation to be incompatible with the European Convention on Human Rights. Although section 4 has empowered senior British judges to issue declarations of incompatibility, Parliament must still decide whether those declarations can invalidate domestic law. This reality has sparked a debate about bi-polar sovereignty between the Parliament and the judiciary. Despite this clear tension between the Parliament and the judiciary, this article contends that parliamentary sovereignty has not been eradicated due to sections 3 and 4 of the HRA

    Characterization of RNase X25 and Lamp1 in Drosophila melanogaster

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    RNases T2 have been shown to be evolutionarily conserved in plants, deutrostomes and protostomes indicating that this ancient enzyme may be playing a conserved housekeeping role in diverse organisms. Indeed, evidence from studies in Arabidopsis, zebrafish and human suggests that RNases T2 are involved in rRNA recycling under normal conditions. In order to further elucidate the function of these enzymes in animals, we characterized RNase X25, the only member of the RNase T2 family present in Drosophila melanogaster. In this study, we have shown that RNase X25 is ubiquitously expressed throughout the life cycle, is a major contributor of ribonuclease activity in Drosophila and is upregulated under conditions of nutritional stress accompanied by a concomitant upregulation of Atg5, an autophagy marker. These findings suggest that RNase X25 has functions similar to those of RNase T2 in other organisms. In order to further clarify the mechanism of rRNA uptake by lysosomes for degradation by RNase X25 in Drosophila melanogaster, we characterized the lysosomal associated membrane glycoprotein, Lamp1. Although it has been used extensively as a lysosomal marker in Drosophila, the actual function of this protein within the lysosomal membrane remains elusive in flies. LAMP2, an ortholog of Lamp1 in humans and mice has three splice variants with conserved luminal regions but different cytoplasmic and transmembrane domains. DmelLamp1 shows the strongest homology with LAMP2C among the three splice variants. Recently, the C-terminal regions of DmelLamp1 and LAMP2C were shown to have very high affinity for RNA isolated from mouse brain. LAMP2A has been implicated in chaperone-mediated autophagy, and LAMP2B deficiency has been shown to cause Danon disease, characterized by cardiomyopathy and myopathy, in humans. In the current study, we have shown that, just as in the case of RNase X25, LAMP1 expression is upregulated under nutritional stress. We have also characterized a loss of function mutant for Lamp1 in Drosophila melanogaster. Lamp1 depletion leads to accumulation of autophagic vacuoles in fat body tissue as evidenced by Lysotracker-red (LTR) staining and upregulation of Atg8 expression. These results warrant further investigation into the putative role of Lamp1 in rRNA binding and transport to the lumen of lysosomes for degradation by RNase X25 in Drosophila

    Application of Smooth Transition autoregressive (STAR) models for Exchange Rate

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    This study evaluates the suitability of the Smooth transition autoregressive (STAR) models specification for real exchange rate Modeling. Our paper investigates the stationarity of real exchange rates which assume linearity in it; we also apply the tests to check stationarity that assume nonlinearity in a particular time series. The focus of this study is to explain the simple matter of time series stationarity or non-stationarity regarding modeling; its principle aim is application of logistic Smooth transition autoregressive (LSTAR) and exponential Smooth transition autoregressive (ESTAR) modeling to Exchange rate series to find the model which better explain its deviation from mean. We found ESTAR adjustment for our data series

    Review of Gravity Model Derivations

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    The gravity model of international trade flows is a common approach to modeling bilateral trade flows. But it is criticized on the ground of weak theoretical base and poor micro-foundation. The gravity equation for describing trade flows first appeared in the empirical literature without much serious attempt to justify it theoretically. The theoretical support for the gravity model was originally very poor, but after the second half of the 1970s, several theoretical developments have filled this gap .In this study we also endeavor to justify the Gravity model specification and derive gravity equation from different perspective. We infer from literature and find it a strong empirical tool of analysis for international trade flows even though of some weakness it innate. Moreover, multilateral trade resistance factors may be added in the empirical estimation to correctly estimate theoretical gravity model. Keywords: Gravity Model, Anderson Gravity Model, Tinbergen Gravity Model, Newton’s Basic

    How do Companies Promote Luxury Brands in United Arab Emirates?

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    Luxury – a word most brands would want to be characterized as. Being a social marker, luxury brands play a key role in the creation of human identity – it influences how they dress and enables them to signify a certain lifestyle. In the past it was fairly easy to brand luxury, as competition was moderate and consumers were quite easy to define and the tendency of consumers to remain loyal and uncritical towards a single-brand.[1] Keeping the above in view, the study was designed to analyze the promotional strategies of three well known automotive brands present in United Arab Emirates. The study indicated that the companies used almost the same modes and mediums for promoting their respective brands. [1] Reference: Kapferer & Bastien, 2009, p. 18 & Okonkwo, 2007, p. 3, 6

    IMPACT OF FDI ON ECONOMY GROWTH: A COMPARISON OF SOUTH ASIAN STATES & CHINA

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    This paper makes a comparison of the impact of Foreign Direct investment on the economies of South Asian states including Pakistan, India, Bangladesh and Sri Lanka with China. The paper attempts to investigate that what are the differences between the economies of South Asia region and China. For study purpose annual data are used. The variables selected are FDI, External Debt, and Remittances. Analytical tools of OLS test and granger causality test are used to analyze the data. The result confirmed the fast growing economic development of China as compared with states of South Asia. The results confirmed that China is much faster growing economy than South Asia region. In order to attract direct investment into the of South Asian states, there is a need to develop infrastructure, stabilized political environment, law and order situation, healthy economic environment, curtailing on external debt, tax exemption. If these countries give due attention to FDI role in economic development FDI can facilitate human capital formation, domestic investment and technology transfer in the region and they can also develop their economies much like that of China
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