5,087 research outputs found
Space-filling design for nonlinear models
Performing a computer experiment can be viewed as observing a mapping between the model parameters and the corresponding model outputs predicted by the computer model. In view of this, experimental design for computer experiments can be thought of as devising a reliable procedure for finding configurations of design points in the parameter space so that their images represent the manifold parametrized by such a mapping (i.e., computer experiments). Traditional space-filling designs aim to achieve this goal by filling the parameter space with design points that are as "uniform" as possible in the parameter space. However, the resulting design points may be non-uniform in the model output space and hence fail to provide a reliable representation of the manifold, becoming highly inefficient or even misleading in case the computer experiments are non-linear. In this paper, we propose an iterative algorithm that fills in the model output manifold uniformly---rather than the parameter space uniformly---so that one could obtain a reliable understanding of the model behaviors with the minimal number of design points
Superconducting gap structure of the 115's revisited
Density functional theory calculations of the electronic structure of Ce- and
Pu-based heavy fermion superconductors in the so-called 115 family are
performed. The gap equation is used to consider which superconducting order
parameters are most favorable assuming a pairing interaction that is peaked at
(\pi,\pi,q_z) - the wavevector for the antiferromagnetic ordering found in
close proximity. In addition to the commonly accepted order
parameter, there is evidence that an extended s-wave order parameter with nodes
is also plausible. We discuss whether these results are consistent with current
observations and possible measurements that could help distinguish between
these scenarios.Comment: 8 pages, 4 figures; Accepted for publication in JPC
First Results from the Large Area Lyman Alpha Survey
We report on a new survey for z=4.5 Lyman alpha sources, the Large Area Lyman
Alpha (LALA) survey. Our survey achieves an unprecedented combination of volume
and sensitivity by using narrow-band filters on the new 8192x8192 pixel CCD
Mosaic Camera at the 4 meter Mayall telescope of Kitt Peak National
Observatory.
Well-detected sources with flux and equivalent width matching known high
redshift Lyman alpha galaxies (i.e., observed equivalent width above 80
Angstroms and line+continuum flux between 2.6e-17 and 5.2e-17 erg/cm^2/sec in
an 80 Angstrom filter) have an observed surface density corresponding to 11000
+- 700 per square degree per unit redshift at z=4.5. Spatial variation in this
surface density is apparent on comparison between counts in 6561 and 6730
Angstrom filters.
Early spectroscopic followup results from the Keck telescope included three
sources meeting our criteria for good Lyman alpha candidates. Of these, one is
confirmed as a z=4.52 source, while another remains consistent with either
z=4.55 or z=0.81. We infer that 30 to 50% of our good candidates are bona fide
Lyman alpha emitters, implying a net density of about 4000 Lyman alpha galaxies
per square degree per unit redshift.Comment: 10 pages, 2 figures (3 .ps files), uses AASTeX 4. Submitted to The
Astrophysical Journal Letter
Two-Temperature Intracluster Medium in Merging Clusters of Galaxies
We investigate the evolution of intracluster medium during a cluster merger,
explicitly considering the relaxation process between the ions and electrons by
N-body and hydrodynamical simulations. When two subclusters collide each other,
a bow shock is formed between the centers of two substructures and propagate in
both directions along the collision axis. The shock primarily heats the ions
because the kinetic energy of an ion entering the shock is larger than that of
an electron by the ratio of masses. In the post-shock region the energy is
transported from the ions to electrons via Coulomb coupling. However, since the
energy exchange timescale depends both on the gas density and temperature,
distribution of electron temperature becomes more complex than that of the
plasma mean temperature, especially in the expanding phase. After the collision
of two subclusters, gas outflow occurs not only along the collision axis but
also in its perpendicular direction. The gas which is originally located in the
central part of the subclusters moves both in the parallel and perpendicular
directions. Since the equilibrium timescale of the gas along these directions
is relatively short, temperature difference between ions and electrons is
larger in the directions tilted by the angles of with respect to
the collision axis. The electron temperature could be significantly lower that
the plasma mean temperature by at most. The significance of our
results in the interpretation of X-ray observations is briefly discussed.Comment: 20 pages, 11 figures, Accepted for publication in Ap
Sorting live stem cells based on Sox2 mRNA expression.
PMCID: PMC3507951This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.While cell sorting usually relies on cell-surface protein markers, molecular beacons (MBs) offer the potential to sort cells based on the presence of any expressed mRNA and in principle could be extremely useful to sort rare cell populations from primary isolates. We show here how stem cells can be purified from mixed cell populations by sorting based on MBs. Specifically, we designed molecular beacons targeting Sox2, a well-known stem cell marker for murine embryonic (mES) and neural stem cells (NSC). One of our designed molecular beacons displayed an increase in fluorescence compared to a nonspecific molecular beacon both in vitro and in vivo when tested in mES and NSCs. We sorted Sox2-MB(+)SSEA1(+) cells from a mixed population of 4-day retinoic acid-treated mES cells and effectively isolated live undifferentiated stem cells. Additionally, Sox2-MB(+) cells isolated from primary mouse brains were sorted and generated neurospheres with higher efficiency than Sox2-MB(-) cells. These results demonstrate the utility of MBs for stem cell sorting in an mRNA-specific manner
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‘If you look the part you’ll get the job’: should career professionals help clients to enhance their career image?
This article presents a critical exploration of the role of career professionals in supporting people to reflect on and enhance their appearance, attractiveness and self-presentation (career image). The article is conceptual and based on a review of the broader literature on career success, appearance and attractiveness. It explores the evidence for a relationship between attractiveness and career, and the authors propose a conceptual framework in which career image is comprised of three elements (interpersonal skills, aesthetic presentation and beauty). The paper examines a possible role for career professionals in relation to this and then critically examines this role and concludes with the proposition of a research agenda in this area
Scaling of the specific heat in superfluid films
We study the specific heat of the model on lattices with (i.e. on lattices representing a film geometry) using the
Cluster Monte--Carlo method. In the --direction we apply Dirichlet boundary
conditions so that the order parameter in the top and bottom layers is zero. We
find that our results for the specific heat of various thickness size
collapse on the same universal scaling function. The extracted scaling function
of the specific heat is in good agreement with the experimentally determined
universal scaling function using no free parameters.Comment: 4 pages, uuencoded compressed PostScrip
N-body simulations of galaxies and groups of galaxies with the Marseille GRAPE systems
I review the Marseille GRAPE systems and the N-body simulations done with
them. I first describe briefly the available hardware and software, their
possibilities and their limitations. I then describe work done on interacting
galaxies and groups of galaxies. This includes simulations of the formation of
ring galaxies, simulations of bar destruction by massive compact satellites, of
merging in compact groups and of the formation of brightest members in clusters
of galaxies.Comment: 13 pages, 5 figures, to be published in "Non-linear Dynamics and
Chaos in Astrophysics", eds. J.R. Buchler, S. Gottesman, J. Hunter and H.
Kandrup, Annals of the New York Academy of Science
S-matrix approach to quantum gases in the unitary limit II: the three-dimensional case
A new analytic treatment of three-dimensional homogeneous Bose and Fermi
gases in the unitary limit of negative infinite scattering length is presented,
based on the S-matrix approach to statistical mechanics we recently developed.
The unitary limit occurs at a fixed point of the renormalization group with
dynamical exponent z=2 where the S-matrix equals -1. For fermions we find T_c
/T_F is approximately 0.1. For bosons we present evidence that the gas does not
collapse, but rather has a critical point that is a strongly interacting form
of Bose-Einstein condensation. This bosonic critical point occurs at n lambda^3
approximately 1.3 where n is the density and lambda the thermal wavelength,
which is lower than the ideal gas value of 2.61.Comment: 26 pages, 16 figure
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