Improved Parameters and New Lensed Features for Q0957+561 from WFPC2 Imaging

New HST WFPC2 observations of the lensed double QSO 0957+561 will allow improved constraints on the lens mass distribution and hence will improve the derived value of H$_0$. We first present improved optical positions and photometry for the known components of this lens. The optical separation between the A and B quasar images agrees with VLBI data at the 10 mas level, and the optical center of the primary lensing galaxy G1 coincides with the VLBI source G' to within 10 mas. The best previous model for this lens (Grogin and Narayan 1996) is excluded by these data and must be reevaluated. Several new resolved features are found within 10\arcsec of G1, including an apparent fold arc with two bright knots. Several other small galaxies are detected, including two which may be multiple images of each other. We present positions and crude photometry of these objects.Comment: 7 pages including 2 postscript figures, LaTeX, emulateapj style. Also available at http://www.astro.lsa.umich.edu:80/users/philf/www/papers/list.htm

Reduced Fine-Tuning in Supersymmetry with R-parity violation

Both electroweak precision measurements and simple supersymmetric extensions of the standard model prefer a mass of the Higgs boson less than the experimental lower limit of 114 GeV. We show that supersymmetric models with R parity violation and baryon number violation have a significant range of parameter space in which the Higgs dominantly decays to six jets. These decays are much more weakly constrained by current LEP analyses and would allow for a Higgs mass near that of the $Z$. In general, lighter scalar quark and other superpartner masses are allowed and the fine-tuning typically required to generate the measured scale of electroweak symmetry breaking is ameliorated. The Higgs would potentially be discovered at hadron colliders via the appearance of new displaced vertices. The lightest neutralino could be discovered by a scan of vertex-less events LEP I data.Comment: 5 pages, 2 figures. Significant detail added to the arguments regarding LEP limits - made more quantitative. Better figures used, plotting more physical quantities. Typos corrected and references updated. Conclusions unchange

The Ellipticity and Orientation of Clusters of Galaxies from N-Body Experiments

In this study we use simulations of 128$^3$ particles to study the ellipticity and orientation of clusters of galaxies in N-body simulations of differing power-law initial spectra (P(k) \propto k^n ,n = +1, 0, -1, -2$), and density parameters ($\Omega_0 = 0.2$to 1.0). Furthermore, unlike most theoretical studies we mimic most observers by removing all particles which lie at distances greater than 2 1/h Mpc from the cluster center of mass. We computed the axial ratio and the principal axes using the inertia tensor of each cluster. The mean ellipticity of clusters increases strongly with increasing$n$. We also find that clusters tend to become more spherical at smaller radii. We compared the orientation of a cluster to the orientation of neighboring clusters as a function of distance (correlation). In addition, we considered whether a cluster's major axis tends to lie along the line connecting it to a neighboring cluster, as a function of distance (alignment). Both alignments and correlations were computed in three dimensions and in projection to mimic observational surveys. Our results show that significant alignments exist for all spectra at small separations ($D < 15 h^{-1}$Mpc) but drops off at larger distance in a strongly$n-$dependent way.Comment: 22 pages, requires aaspp4.sty, flushrt.sty, and epsf.sty Revised manuscript, accepted for publication in Ap

Diabetes mellitus: Complex interplay between metformin, AKI and lactic acidosis.

Debate exists regarding the safety of metformin and the risk of metformin-associated lactic acidosis, particularly in the setting of kidney dysfunction. Data from two studies examining the interplay between metformin, acute kidney injury, and complications including lactic acidosis suggest that metformin should be used conservatively in patients with kidney dysfunction

Long-term safety of siltuximab in patients with idiopathic multicentric Castleman disease: a prespecified, open-label, extension analysis of two trials.

BACKGROUND:Siltuximab is recommended by international consensus as a first-line treatment for idiopathic multicentric Castleman disease on the basis of durable efficacy and safety data. This study was done to assess the long-term safety and activity of siltuximab over up to 6 years of treatment. METHODS:This study is a prespecified open-label extension analysis of a phase 1 trial (NCT00412321) and a phase 2 trial (NCT01024036), done at 26 hospitals worldwide. Patients in both studies were at least 18 years old with histologically confirmed, symptomatic Castleman disease. This extension study enrolled 60 patients who completed the previous trials without disease progression on siltuximab. Patients received siltuximab infusions of 11 mg/kg every 3 weeks (which could be extended to 6 weeks) for up to 6 years. Descriptive statistics were used to summarise the data. No formal hypothesis testing was performed. The primary endpoint was the safety of siltuximab, assessed at each dosing cycle. The study was registered with ClinicalTrials.gov, number NCT01400503 and with EudraCT, number 2010-022837-27. FINDINGS:Patient enrolment into the phase 1 trial was from June 20, 2005, to Sept 15, 2009, and enrolment into the phase 2 trial was from Feb 9, 2010, to Feb 3, 2012. Patients were enrolled in this long-term extension from April 1, 2011, to Jan 15, 2014. Median follow-up was 6 years (IQR 5·11-7·76). Median treatment duration, from the beginning of the previous trials to the end of the present study, was 5·5 years (IQR 4·26-7·14). Siltuximab was well tolerated; however, adverse events of grade 3 or worse were reported in 36 (60%) of 60 patients with the most common being hypertension (eight [13%]), fatigue (five [8%]), nausea (four [7%]), neutropenia (four [7%]), and vomiting (three [5%]). 25 (42%) patients reported at least one serious adverse event, which most commonly was an infection (eight [13%]). Only two serious adverse events, polycythaemia and urinary retention, were considered related to siltuximab treatment. 18 patients discontinued before study completion, either to receive siltuximab locally (eight) or because of progressive disease (two), adverse events (two), or other reasons (six). No deaths were reported. INTERPRETATION:These results show that siltuximab is well tolerated long term and provides important evidence for the feasibility of the life-long use required by patients with idiopathic multicentric Castleman disease. FUNDING:Janssen R&amp;D and EUSA Pharma

Teaching LLCs Through a Problem-Based Approach

Case studies and case simulations can be used to teach LLCs with an eye toward training business lawyers. These tools can be used in the traditional four-credit Business Associations (BA) course to supplement traditional teaching materials with mini-case studies that accent and apply analysis of primary legal sources. Alternatively, case studies and case simulations can be the centerpiece of a specialized course on LLCs. We discuss both approaches in this short essay

Warm dust in the terrestrial planet zone of a sun-like Pleiad: collisions between planetary embryos?

Only a few solar-type main sequence stars are known to be orbited by warm dust particles; the most extreme is the G0 field star BD+20 307 that emits ~4% of its energy at mid-infrared wavelengths. We report the identification of a similarly dusty star HD 23514, an F6-type member of the Pleiades cluster. A strong mid-IR silicate emission feature indicates the presence of small warm dust particles, but with the primary flux density peak at the non-standard wavelength of ~9 micron. The existence of so much dust within an AU or so of these stars is not easily accounted for given the very brief lifetime in orbit of small particles. The apparent absence of very hot (>~1000 K) dust at both stars suggests the possible presence of a planet closer to the stars than the dust. The observed frequency of the BD+20 307/HD 23514 phenomenon indicates that the mass equivalent of Earth's Moon must be converted, via collisions of massive bodies, to tiny dust particles that find their way to the terrestrial planet zone during the first few hundred million years of the life of many (most?) sun-like stars. Identification of these two dusty systems among youthful nearby solar-type stars suggests that terrestrial planet formation is common.Comment: ApJ in press, 19 pages including 3 figures and 2 tables, minor changes to the tables and figure

Time--Splitting Schemes and Measure Source Terms for a Quasilinear Relaxing System

Several singular limits are investigated in the context of a $2 \times 2$ system arising for instance in the modeling of chromatographic processes. In particular, we focus on the case where the relaxation term and a $L^2$ projection operator are concentrated on a discrete lattice by means of Dirac measures. This formulation allows to study more easily some time-splitting numerical schemes