Optimization of PVA-Arabic Gum–Honey-based Electrospun Nanofibers as Candidate Carrier for Peptide and Protein Delivery

Nanofibers dressing exhibit several advantageous characteristics for accelerating wound healing, such as its similar structure to the extracellular matrix (ECM), high surface area/volume ratio, high porosity and high loading capacity of drug. The nanofibers dressing which were prepared by the electrospinning technique using combination of synthetic and natural polymer excipients capable of fulfilling the ideal wound dressing criteria. This study aimed to develop nanofibers dressing prepared from polyvinyl alcohol (PVA), Arabic gum (GA) and honey by electrospinning method. This study focused on the effect of electrospinning parameters and the morphology of electrospun nanofibers of the blended solutions made from PVA (9% w/v) – GA (1% w/v) and honey (at varied concentrations of 0;1;3% w/v) with or without Triton X-100 (0.05% v/v). The effect of varied process parameters such as voltage and flow rate in electrospinning was also investigated. The blended solutions with the various concentration of honey at 0;1;3% w/v and Triton X-100 were named as FAt, FBt, and FCt, respectively, while the blended solutions without Triton X-100, were named as FA, FB, and FC. The optimum electrospining parameter were 18 KV and 5 µl/minute for FAt, FBt, and FCt; and 20 KV and 10 µl/minute for FA, FB, and FC. Electrospun nanofibers of FAt, FBt, FCt showed smoother and more uniform fibers in comparison to the nanofibers FA, FB, and FC. The average nanofibers diameter of FAt, FBt, FCt were 244±45; 266±45; 283±57 nm, respectively, while the average nanofibers diameter of FA, FB, FC was 406±140, 457±168, 594±204 nm, respectively. Higher concentration of honey increased the diameters of nanofibers. The average nanofibers diameter of FAt, FBt, and FCt were within nanoscale in range of the ECM (50-500 nm), which were suitable for accelerating wound healing. Therefore, this study indicated that PVA-GA-honey nanofibers dressing is suitable to be further developed as carrier for growth factors

The role of gratitude on stress and psychological wellbeing among parent of children with cancer in Aceh

Cancer is a disease with a high incidence that pediatric patients need parents during treatment. The situation became a source of stress for parents. One way to deal with stress is to be grateful that the psychological wellbeing of the caregivers who accompany children with cancer is maintained. This study aims to determine the relationship between stress and psychological wellbeing with the moderation of gratitude in the parents of children with cancer in Aceh. This study used a quantitative approach, involving 14 participants at the shelter for children with cancer undergoing treatment in Banda Aceh aged 20–40 years. Participants were selected using the non-probability sampling method and the incidental sampling technique. Individual stress levels were measured using the Perceived Stress Scale, wellbeing using the Warwick-Edinburgh Mental Wellbeing Scale, and gratitude using the Indonesian Grateful Scale. The data were analyzed using the Rank Spearman nonparametric test, showing no relationship between stress and psychological wellbeing, but there is a relationship between stress and gratitude and gratitude with psychological wellbeing. This result shows partially that gratitude has a relationship with stress and psychological wellbeing. It means that with gratitude, stress can be controlled and impacts the psychological wellbeing of parents accompanying children with cancer

EFEKTIFITAS LAYANAN KONSELING KELOMPOK DALAM MENINGKATKAN KEDISIPLINAN SISWA DI MADRASAH ALIYAH NEGERI 1 MEDAN

The purpose of this study was to determine whether group counseling services improved the attitudes of MAN 1 MEDAN students toward discipline. This study uses a survey method. This study uses descriptive qualitative research. In qualitative research, researchers use data to answer questions or leave it up to interpretation. Careful observation, detailed contextual descriptions, extensive interview transcripts, and analysis of documents and records all contributed to data collection. The reconnaissance was directed at MAN 1 MEDAN located at Jalan William Iskandar No.7 B, Sidoarjo, Medan Tembun District, Medan City. The meeting will take place from Thursday to Saturday, October 20- 22, 2022 in the Orientation and Counseling Room (BK). At Madrasah Ariya Negri 1 Medan, I spoke with his counseling teacher and learned about his group counseling. This study aimed to determine the effectiveness of the MAN 1 MEDAN student group counseling service. MAN 1 MEDAN uses group counseling techniques to solve problems