Comparison the effectiveness of Emotion-Focused Couple and Acceptance and Commitment Therapies on Marital Forgiveness in Incompatible Couples

Background: Using effective interventions to reduce incompatibility among couples can play a role in preventing divorce in the family. The present study aimed to compare the effectiveness of emotion-focused couple therapy (EFCT) and acceptance and commitment therapy (ACT) on forgiveness in incompatible couples. Methods: The present research is a quasi-experimental study that was done on couples referred to a family therapy clinic in Torbat-e-Jam City. Here, 24 incompatible couples were selected through purposive methods and randomly replaced in three groups. The first and second groups (8 couples in each group) received emotion-focused couples and acceptance and commitment therapies, respectively, and the third group as control (8 couples) did not receive any intervention during the study period. All three groups were evaluated before and after the intervention with a standard questionnaire of Bagarozi forgiveness (2001). Data were analyzed through SPSS software version 20 and covariance analysis. Results: The findings revealed that both therapies of EFCT and ACT had a meaningful effect on forgiveness (P < 0.001, F = 41.73, and P = 0.031, F = 5.13; respectively); while the results indicated that the two groups under intervention have no significant difference in terms of effectiveness on the variable of forgiveness (P=0.63, F=0.23). Conclusion: According to the results and effectiveness of the two therapy groups, it is recommended to use a combination of approaches according to the therapeutic goals

Losartan inhibits sars-cov-2 replication in vitro

Purpose: SARS-CoV-2 infection is associated with substantial mortality and high morbidity. This study tested the effect of angiotensin II type I receptor blocker, losartan, on SARS-CoV-2 replication and inhibition of the papain-like protease of the virus. Methods: The dose-dependent inhibitory effect of losartan, in concentrations from 1μM to 100μM as determined by quantitative cell analysis combining fluorescence microscopy, image processing, and cellular measurements (Cellomics analysis) on SARS-CoV-2 replication was investigated in Vero E6 cells. The impact of losartan on deubiquitination and deISGylation of SARS-CoV-2 papain-like protease (PLpro) were also evaluated.  Results: Losartan reduced PLpro cleavage of tetraUbiquitin to diUbiquitin.  It was less effective in inhibiting PLpro’s cleavage of ISG15-AMC than Ubiquitin-AMC.  To determine if losartan inhibited SARS-CoV-2 replication, losartan treatment of SARS-CoV-2 infected Vero E6 was examined. Losartan treatment one hour prior to SARS-CoV-2 infection reduced levels of SARS-CoV-2 nuclear protein, an indicator of virus replication, by 80% and treatment one-hour post-infection decreased viral replication by 70%. Conclusion: Losartan was not an effective inhibitor of deubiquitinase or deISGylase activity of the PLpro but affected the SARS-CoV-2 replication of Vero E6 cells in vitro.  As losartan has a favorable safety profile and is currently available it has features necessary for efficacious drug repurposing and treatment of COVID-19

Protective effects of curcumin on diabetic nephropathy via attenuation of kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) expression and alleviation of oxidative stress in rats with type 1 diabetes

Objective(s): One of the serious complications of Type1 diabetes (T1D) is diabetic nephropathy, which is accompanied with overexpression of kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) and enhanced oxidative stress. The present study was conducted to examine the protective effect of curcumin on the expression of KIM-1, NGAL genes and oxidative damage in the kidney of T1D rats. Materials and Methods: Thirty-six adult male rats were divided into 6 groups (n=6). The control and T1D groups received treatment with curcumin or without it (80 and 130 mg/kg, respectively). After 60 days of treatment, using spectrophotometric methods, biochemical factors and oxidative stress markers were measured. Gene expression of KIM-1 and NGAL was evaluated using quantitative PCR.  Also, plasma and urine levels of these two proteins were assayed by the ELISA kit. Results: Diabetes caused a significant increase in the levels of creatinine, FBS, uric acid, urea, and creatinine in the serum, which were attenuated after the administration of curcumin. There was a significant reduction in the values of creatinine, uric acid, and urea in urine in the diabetic group whereas in the rats treated with curcumin, these values were normalized to the normal level (especially in 130 mg/kg). Curcumin administration had a significant role in modulation of serum lipid profile, and it was shown to decrease the kidney and urinary expression levels of KIM-1 and NGAL genes and improve oxidative toxic stress in the kidney tissues.Conclusion: Curcumin can play a protective role in reducing the unpleasant consequences of diabetic nephropathy

Are Losartan and Imatinib Effective Against SARS-CoV2 Pathogenesis? a Pathophysiologic-Based in Silico Study

COVID19 has spread all over the globe with ARDS as the most grave complicating factor in its mortality and morbidity. As there is not an effective anti-viral drug or an imminent vaccine against this virus we proposed a novel insight about cytokine storm-indiced ARDS in this disease and conducted an in silico study according to the pathophysiology of cytokine storm. We found that losartan and imatinib may break the life cycle of the virus to the degree that its affinity to ACE2 may decline, the function of papin-like protease disrupts, and the cytokine storm may subside, as well. This means that the death toll of the disease may decline sharply till a vaccine is produced in the near future. All the results should be validated in subclinical studies.</div

Nonlinear mathematical modeling of vibrating motion of nanomechanical cantilever active probe

Nonlinear vibration response of nanomechanical cantilever (NMC) active probes in atomic force microscope (AFM) application has been studied in the amplitude mode. Piezoelectric layer is placed piecewise and as an actuator on NMC. Continuous beam model has been chosen for analysis with regard to the geometric discontinuities of piezoelectric layer attachment and NMC's cross section. The force between the tip and the sample surface is modeled using Leonard-Jones potential. Assuming that cantilever is inclined to the sample surface, the effect of nonlinear force on NMC is considered as a shearing force and the concentrated bending moment is regarded at the end. Nonlinear frequency response of NMC is obtained close to the sample surface using the dynamic modeling. It is then become clear that the distance and angle of NMC, the probe length, and the geometric dimensions of piezoelectric layer can affect frequency response bending of the curve

Program Reliability Estimation Tool By

Testing is a very demanding procedure in software production, that takes a lot of e ort, time and resources during both development and maintenance. Moreover, statistical testing is a very costly procedure, especially if high reliability requirements are placed on the software as in safety-critical, or safety-related software cases. The main question is when to stop testing, or how many tests are needed? Singh et al. [49], using the method of the negative binomial, developed a procedure for quantifying the reliability ofamodule. According to their approach, the number of tests can be computed based on hypothesis testing. We implemented this method for a reliability estimation of a program. In this work, a prototype black-box automated testing tool, called Program Re-liability Estimation Tool (PRET) was developed as a statistical test generator and reliability estimation tool based on an operational pro le (a proposed testing model) and negative binomial sampling. The tool has a command line user interface. The inputs to the PRET are: an integer (0 or 1) to choose the usage (0: only generate test cases, 1: does the testing process), the test speci cation context le name, the data le name, the program under test name, and the oracle name. PRET computes the number of test cases, generates test cases, runs the generated test cases, evaluates the result of each test run by using an oracle, and estimates the reliability ofthe program based on test results. ii Acknowledgements Iwould like to express my sincere and deepest thanks to Professor David L. Parnas for his guidance, insight, enthusiasm, encouragement and constant support throughout the preparation of this work. Iamvery grateful to Dr. Roman Viveros and Dr. Ridha Khedri for their support, time and their helpful comments on this thesis. sions. Iwould like to thank Dr. Dennis Peters for many helpful and encouraging discus-I would like to thank Mr. Ross Steingrimsson for testing the tool and his useful suggestions. I would like tothank Mrs. Doris Burns for all her help. Iwould like toacknowledge the nancial support of the Natural Sciences and En

Periodontal Problems Following Surgical Extraction of Impacted

Introduction:There are conflicting reports on the effects of surgical removal of impacted mandibular third molars on the periodontium of the adjacent teeth. The aim of this study was to compare the condition of the periodontium six months after extraction of impacted mandibular third molars with baseline values. Methods: Fifty patients with mesioangular impacted mandibular third molarsparticipated in this study. Probing depth (PD), Leo and Sillness' gingival index (GI), and clinical attachment level (CAL) in distobuccal, mid-distal, and distolingual surfaces of second molar teeth were assessed before surgical extraction of the third molars and 6 months later. To evaluate the changes in alveolar bone height (BH), two parallel PA radiographs obtained at the baseline and follow-up session. Data was analyzed with SPSS 11.0 software atthe confidence interval of 95%. Results: Thirty-eight females and 12 males participated in this study. Twenty-eight(56%) of impacted molar teeth were in the right side and 22 (44%) were in the left side. Baseline values of PD, CAL, and GI at three points of the distal surface of the mandibular second molar tooth had no significant differences with follow-up values (P-value> 0.05). According to the radiographs, baseline BH also had insignificant difference with follow-up height (P-value>0.05). Conclusion: Surgical removal of impacted mandibular third molar does not affect periodontium after 6 months

Platelet-Rich Fibrin: An Autologous Fibrin Matrix in Surgical Procedures: A Case Report and Review of Literature

Introduction: The healing process after surgery is a challenging issue for surgeons. Various materials and techniques have been developed to facilitate this process and reduce its period. Fibrin adhesives are often used in cardiothoracic and vascular surgery to seal diffuse microvascular bleeding and in general and plastic surgery to seal wound borders. This Case report and literature review will introduce the various usages of platelet-rich fibrin in different surgical procedures and the method of producing the matrix. Case Report: A 24-year old man with periorbital skin avulsion treated with PRF membrane has been reported and discussed in this paper.  Conclusion: Platelet-rich fibrin is a natural autologous fibrin matrix, which can be produced with a simple blood sample and a table centrifuge. The material has been used in a wide range of surgical procedures to shorten the healing period and reduce post-surgical complications