Soluble Fas might serve as a diagnostic tool for gastric adenocarcinoma

<p>Abstract</p> <p>Background</p> <p>Fas (Apo-1/CD95) and its specific ligand (FasL) are key elements in apoptosis. They have been studied in different malignancies but there are few published studies about the soluble forms of these markers (i.e. sFas/sFasL) in gastric cancer. We have compared the serum levels of sFas/sFasL in gastric adenocarcinoma patients and cases with pre-neoplastic lesions as potential markers for early diagnosis, and investigated their relation with clinicopathological characteristics.</p> <p>Methods</p> <p>Fifty-nine newly-diagnosed cases of gastric adenocarcinoma who had undergone gastrectomy, along with 62 endoscopically- and histologically-confirmed non-cancer individuals were enrolled in this study. sFas/sFasL serum levels were detected by Enzyme Linked Immunosurbent Assay.</p> <p>Results</p> <p>Mean serum sFas level was significantly higher in gastric cancer patients than in control group (305.97 ± 63.71 (pg/ml) vs. 92.98 ± 4.95 (pg/ml), P < 0.001); while the mean serum level of sFasL was lower in patients with gastric adenocarcinoma (0.138 ± 0.04 (pg/ml) vs. 0.150 ± 0.02 (pg/ml), P < 0.001). Mean serum levels of sFas/sFasL were significantly different in both intestinal/diffuse and cardiac/non-cardiac subtypes when compared to the control group (P < 0.001). There was an increase in the serum level of sFas from the first steps of pre-neoplastic lesions to gastric adenocarcinoma (P < 0.001). Patients who had no lymph node involvement (<it>N₀</it>) showed significantly higher serum levels of sFas compared to others (P = 0.044).</p> <p>Conclusions</p> <p>Production of sFas may play a critical role in the carcinogenesis of intestinal-type gastric cancer. sFas serum level may serve as a non-invasive tool for early diagnosis of gastric cancer.</p

A multi objective fuzzy-based controller for front differential vehicles by electrical traction system on non-driven wheels

Using electrical machine in conventional vehicles, also called hybrid vehicles, has become a promising control scheme that enables some manners for fuel economy and driver assist for better stability. In this paper, vehicle stability control, fuel economy and Driving/Regeneration braking for a 4WD hybrid vehicle is investigated by using an electrical machine on each non-driven wheels. Fourteen degree of freedom vehicle body modeling and ADVISOR power-train/electrical components model will be used for modeling. Driving/Regeneration and stability enhancement are important in low and high speed respectively. The unequaled independent torques applied to the non-driven wheels provides the ability of vehicle dynamic control to assist the driver with path correction, thus enhancing cornering and straight-line stability and providing enhanced safety. So power managing between engine and electrical machines will be provided the fuel economy and regeneration in braking condition. For these goals, power management and Yaw moment control will be down in low and high speed respectively by proper fuzzy controller. Finally, a series of MATLAB/SIMULINK simulation will carried out to evaluate the performance of the proposed structure

A novel hierarchical technique for range segmentation of large building exteriors

Complex multiple structures, high uncertainty due to the existence of moving objects, and significant disparity in the size of features are the main issues associated with processing range data of outdoor scenes. The existing range segmentation techniques have been commonly developed for laboratory sized objects or simple architectural building features. In this paper, main problems related to the geometrical segmentation of large and significant buildings are studied. A robust and accurate range segmentation approach is also devised to extract very fine geometric details of building exteriors. It uses a hierarchical model-base range segmentation strategy and employs a high breakdown point robust estimator to deal with the existing discrepancies in size and sampling rates of various features of large outdoor objects. The proposed range segmentation algorithm facilitates automatic generation of fine 3D models of environment The computational advantages and segmentation capabilities of the proposed method are shown using real range data of large building exteriors

Nanocomposite Based on HA/PVTMS/Cl2FeH8O4 as a Gas and Temperature Sensor

In this paper, a novel nanocrystalline composite material of hydroxyapatite (HA)/polyvinyltrimethoxysilane (PVTMS)/iron(II)chloride tetrahydrate (Cl2FeH8-O4) with hexagonal structure is proposed for the fabrication of a gas/temperature sensor. Taking into account the sensitivity of HA to high temperatures, to prevent the collapse and breakdown of bonds and the leakage of volatiles without damaging the composite structure, a freeze-drying machine is designed and fabricated. X-ray diffraction, FTIR, SEM, EDAX, TEM, absorption and photoluminescence analyses of composite are studied. XRD is used to confirm the material structure and the crystallite size of the composite is calculated by the Monshi&ndash;Scherrer method, and a value of 81.60 &plusmn; 0.06 nm is obtained. The influence of the oxygen environment on the absorption and photoluminescence measurements of the composite and the influence of vaporized ethanol, N2 and CO on the SiO2/composite/Ag sensor device are investigated. The sensor with a 30 nm-thick layer of composite shows the highest response to vaporized ethanol, N2 and ambient CO. Overall, the composite and sensor exhibit a good selectivity to oxygen, vaporized ethanol, N2 and CO environments