920 research outputs found
Thickness dependence of spin-orbit torques generated by WTe2
We study current-induced torques in WTe2/permalloy bilayers as a function of
WTe2 thickness. We measure the torques using both second-harmonic Hall and
spin-torque ferromagnetic resonance measurements for samples with WTe2
thicknesses that span from 16 nm down to a single monolayer. We confirm the
existence of an out-of-plane antidamping torque, and show directly that the
sign of this torque component is reversed across a monolayer step in the WTe2.
The magnitude of the out-of-plane antidamping torque depends only weakly on
WTe2 thickness, such that even a single-monolayer WTe2 device provides a strong
torque that is comparable to much thicker samples. In contrast, the
out-of-plane field-like torque has a significant dependence on the WTe2
thickness. We demonstrate that this field-like component originates
predominantly from the Oersted field, thereby correcting a previous inference
drawn by our group based on a more limited set of samples.Comment: 8 pages, 8 figure
Spin-orbit torques in NbSe/Permalloy bilayers
We present measurements of current-induced spin-orbit torques generated by
NbSe, a fully-metallic transition-metal dichalcogenide material, made using
the spin-torque ferromagnetic resonance (ST-FMR) technique with
NbSe/Permalloy bilayers. In addition to the out-of-plane Oersted torque
expected from current flow in the metallic NbSe layer, we also observe an
in-plane antidamping torque with torque conductivity (m) and indications of a weak field-like
contribution to the out-of-plane torque oriented opposite to the Oersted
torque. Furthermore, in some samples we also measure an in-plane field-like
torque with the form , where is the Permalloy
magnetization direction and is perpendicular to the sample plane. The
size of this component varies strongly between samples and is not correlated
with the NbSe thickness. A torque of this form is not allowed by the bulk
symmetries of NbSe, but is consistent with symmetry breaking by a
uniaxial strain that might result during device fabrication.Comment: 14 pages, 3 figure
Substantial subpial cortical demyelination in progressive multiple sclerosis: have we underestimated the extent of cortical pathology?
Aim: Multiple sclerosis (MS) is an inflammatory demyelinating and neurodegenerative disease. Much of the complex symptomatology relates to pathology outside the classic white matter plaque, whereby lesions of the cortical grey matter, which are difficult to resolve by conventional clinical imaging, are in part predictive of outcome. We investigated the extent of grey matter pathology in whole coronal macrosections to reassess the contribution of cortical pathology to total demyelinating lesion area in progressive MS. Methods: Twenty-two cases of progressive MS were prepared as whole bi-hemispheric macrosections for histology, immunostaining and quantitative analysis of lesion number and relative area, leptomeningeal inflammation and microglial/macrophage activation. Results: Cortical grey matter demyelination was seen in all cases, which was more extensive than in white and deep grey matter (hippocampus, thalamus and basal ganglia) and accounted for 0.8%-60.2% of the entire measurable cortical ribbon. The pattern of cortical grey matter demyelination was predominantly subpial (mean 90.9%, range 60%-100%, of total cortical grey matter lesion area) and cases with the largest areas of subpial cortical lesions had more and larger deep grey matter lesions, greater numbers of activated microglia/macrophages, both in lesions as well as in normal cortical grey matter, together with elevated leptomeningeal inflammation and lymphoid-like structures. White matter lesion area was unchanged when compared with the progressive MS cases with little subpial cortical demyelination. Conclusion: Analysis of whole coronal macrosections reveals cortical demyelination is more extensive than reported by conventional histological methods. Cases of progressive MS with substantial subpial cortical demyelination that is independent of underlying white matter lesion area support the implications that these lesions may in-part arise through different pathogenetic mechanisms. Biomarkers and/or imaging correlates of this subpial pathology are required if we are to fully comprehend the clinical disease process
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Upland streamwater nitrate dynamics across decadal to sub-daily timescales: a case study of Plynlimon, Wales
Streamwater nitrate dynamics in the River Hafren, Plynlimon, mid-Wales were investigated over decadal to sub-daily timescales using a range of statistical techniques. Long-term data were derived from weekly grab samples (1984–2010) and high-frequency data from 7-hourly samples (2007–2009) both measured at two sites: a headwater stream draining moorland and a downstream site below plantation forest. This study is one of the first to analyse upland streamwater nitrate dynamics across such a wide range of timescales and report on the principal mechanisms identified. The data analysis provided no clear evidence that the long-term decline in streamwater nitrate concentrations was related to a decline in atmospheric deposition alone, because nitrogen deposition first increased and then decreased during the study period. Increased streamwater temperature and denitrification may also have contributed to the decline in stream nitrate concentrations, the former through increased N uptake rates and the latter resultant from increased dissolved organic carbon concentrations. Strong seasonal cycles, with concentration minimums in the summer, were driven by seasonal flow minimums and seasonal biological activity enhancing nitrate uptake. Complex diurnal dynamics were observed, with seasonal changes in phase and amplitude of the cycling, and the diurnal dynamics were variable along the river. At the moorland site, a regular daily cycle, with minimum concentrations in the early afternoon, corresponding with peak air temperatures, indicated the importance of instream biological processing. At the downstream site, the diurnal dynamics were a composite signal, resultant from advection, dispersion and nitrate processing in the soils of the lower catchment. The diurnal streamwater nitrate dynamics were also affected by drought conditions. Enhanced diurnal cycling in Spring 2007 was attributed to increased nitrate availability in the post-drought period as well as low flow rates and high temperatures over this period. The combination of high-frequency short-term measurements and long-term monitoring provides a powerful tool for increasing understanding of the controls of element fluxes and concentrations in surface waters
The effect of disgust-related side-effects on symptoms of depression and anxiety in people treated for cancer: a moderated mediation model
As maladaptive disgust responses are linked to mental health problems, and cancer patients
may experience heightened disgust as a result of treatments they receive, we explored the
associations between disgust-related side-effects and symptoms of depression and anxiety in
people treated for cancer. One hundred and thirty two (83 women, Mage = 57.48 years)
participants answered questions about their treatments, side-effects, disgust responding, and
mental health. Experiencing bowel and/or bladder problems, sickness and/or nausea (referred
to here as “core” disgust-related side-effects) was significantly related to greater symptoms of
depression and borderline increased anxiety. Further, these links were explained by a
moderated mediation model, whereby the effects of core disgust side-effects on depression
and anxiety were mediated by (physical and behavioural) self-directed disgust, and disgust
propensity moderated the effect of core disgust side-effects on self-disgust. These findings
stress the importance of emotional responses, like disgust, in psychological adaptation to the
side-effects of cancer treatments
Complement is activated in progressive multiple sclerosis cortical grey matter lesions
The symptoms of multiple sclerosis (MS) are caused by damage to myelin and nerve cells in the brain and spinal cord. Inflammation is tightly linked with neurodegeneration, and it is the accumulation of neurodegeneration that underlies increasing neurological disability in progressive MS. Determining pathological mechanisms at play in MS grey matter is therefore a key to our understanding of disease progression
The Deep Propagating Gravity Wave Experiment (DEEPWAVE): An airborne and ground-based exploration of gravity wave propagation and effects from their sources throughout the lower and middle atmosphere
The Deep Propagating Gravity Wave Experiment (DEEPWAVE) was designed to quantify gravity wave (GW) dynamics and effects from orographic and other sources to regions of dissipation at high altitudes. The core DEEPWAVE field phase took place from May through July 2014 using a comprehensive suite of airborne and ground-based instruments providing measurements from Earth’s surface to ∼100 km. Austral winter was chosen to observe deep GW propagation to high altitudes. DEEPWAVE was based on South Island, New Zealand, to provide access to the New Zealand and Tasmanian “hotspots” of GW activity and additional GW sources over the Southern Ocean and Tasman Sea. To observe GWs up to ∼100 km, DEEPWAVE utilized three new instruments built specifically for the National Science Foundation (NSF)/National Center for Atmospheric Research (NCAR) Gulfstream V (GV): a Rayleigh lidar, a sodium resonance lidar, and an advanced mesosphere temperature mapper. These measurements were supplemented by in situ probes, dropsondes, and a microwave temperature profiler on the GV and by in situ probes and a Doppler lidar aboard the German DLR Falcon. Extensive ground-based instrumentation and radiosondes were deployed on South Island, Tasmania, and Southern Ocean islands. Deep orographic GWs were a primary target but multiple flights also observed deep GWs arising from deep convection, jet streams, and frontal systems. Highlights include the following: 1) strong orographic GW forcing accompanying strong cross-mountain flows, 2) strong high-altitude responses even when orographic forcing was weak, 3) large-scale GWs at high altitudes arising from jet stream sources, and 4) significant flight-level energy fluxes and often very large momentum fluxes at high altitudes
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