Who Ya Gonna Call? Networks of Rural School Administrators

When they need help or advice, who are rural school administrators going to call? Relationships among rural school administrators develop into networks that can affect the success of administrators and their schools. Understanding the structure and content of these networks provides insights into how resources, innovations, and communication flow both within and between rural district administrators. Based on network theory and analysis, this study examines the structure, content, and strategic implications of the administrative networks within and across six contiguous rural school districts in the Western United States. Network graphs are included, illustrating both individual district and the combined six-district rural administrator networks. While acquaintance ties and active work ties are evident both within and across districts, relationally embedded ties and greater cohesion of ties are more evident within districts than across districts. Analyses include consideration of administrative assignment, gender, and geographical location of the network structures. Strategic implications of the network structures and content are discussed

Safety and pharmacokinetics of MM-302, a HER2-targeted antibody–liposomal doxorubicin conjugate, in patients with advanced HER2-positive breast cancer: A phase 1 dose-escalation study

BackgroundThis phase 1 dose-escalation trial studied MM-302, a novel HER2-targeted PEGylated antibody-liposomal doxorubicin conjugate, in HER2-positive locally advanced/metastatic breast cancer.MethodsPatients were enrolled in four cohorts: MM-302 monotherapy (8, 16, 30, 40, and 50 mg/m2 every 4 weeks [q4w]); MM-302 (30 or 40 mg/m2 q4w) plus trastuzumab (4 mg/kg q2w); MM-302 (30 mg/m2) plus trastuzumab (6 mg/kg) q3w; MM-302 (30 mg/m2) plus trastuzumab (6 mg/kg) and cyclophosphamide (450 mg/m2) q3w.ResultsSixty-nine patients were treated. The most common adverse events (AEs) were fatigue and nausea. Grade 3/4 AEs of special interest included neutropenia, fatigue, mucosal inflammation, anemia, thrombocytopenia, febrile neutropenia, and palmar-plantar erythrodysesthesia. The MTD was not reached. With MM-302 ≥ 30 mg/m2, overall response rate (ORR) was 13% and median progression-free survival (mPFS) 7.4 months (95% CI: 3·5-10·9) in all arms. In 25 anthracycline-naïve patients, ORR was 28·0% and mPFS 10·9 months (95% CI: 1·8-15·3). Imaging with 64Cu-labeled MM-302 visualized tumor-drug penetrance in tumors throughout the body, including the brain.ConclusionMM-302 monotherapy, in combination with trastuzumab, or trastuzumab plus cyclophosphamide, was well tolerated and showed promising efficacy. The selected phase 2 MM-302 dose was 30 mg/m2 plus 6 mg/kg trastuzumab q3w

Exile Vol. X No. 1

FICTION The Contest by Jon Reynolds 7-19 Engagement by John Hunting 23-34 Sea Scape by Ellen Heath 35-37 The Gift of the Pelican Keeper by Bart Estes 38-43 Trillium of Guilt by David Kay 46-50 The Enormous Snowfall by Ed Brunner 52-65 Story by Jane Cogie 66-67 POETRY Karen\u27s Elegy by Al Werder 20-21 Chicken Little by Curt Matthews 34 Autumn by Judy Pister 37 Poem by Curt Matthews 44 Madame Bovary by Al Werder 65 GRAPHICS Monoprint by Kathy Knapp 5 Pen and Ink by Bob Tauber 6 Linocut by Parker Waite III 22 Linocut by Jeff Barnes 38 Linocut by Jack Reilly 43 Water color by Kathy Knapp 45 Linocut by Bob Tauber 51 Awarded the semi-annual EXILE-Denison Bookstore Writing Prize: The Gift of the Pelican Keeper by Bart Estes 38-4

Policy recommendations for learning analytics from three stakeholder workshops

This document presents policy recommendations related to the use of learning analytics and educational data mining from three LACE workshops