21,419 research outputs found
Thermodynamic quantum critical behavior of the Kondo necklace model
We obtain the phase diagram and thermodynamic behavior of the Kondo necklace
model for arbitrary dimensions using a representation for the localized and
conduction electrons in terms of local Kondo singlet and triplet operators. A
decoupling scheme on the double time Green's functions yields the dispersion
relation for the excitations of the system. We show that in there is
an antiferromagnetically ordered state at finite temperatures terminating at a
quantum critical point (QCP). In 2-d, long range magnetic order occurs only at
T=0. The line of Neel transitions for varies with the distance to the
quantum critical point QCP as, where the shift
exponent . In the paramagnetic side of the phase diagram, the
spin gap behaves as for consistent with
the value found for the dynamical critical exponent. We also find in this
region a power law temperature dependence in the specific heat for
and along the non-Fermi liquid trajectory. For , in the so-called Kondo spin liquid phase, the thermodynamic
behavior is dominated by an exponential temperature dependence.Comment: Submitted to PR
Prediction of protein-protein interactions using one-class classification methods and integrating diverse data
This research addresses the problem of prediction of protein-protein interactions (PPI)
when integrating diverse kinds of biological information. This task has been commonly
viewed as a binary classification problem (whether any two proteins do or do not interact)
and several different machine learning techniques have been employed to solve this
task. However the nature of the data creates two major problems which can affect results.
These are firstly imbalanced class problems due to the number of positive examples (pairs
of proteins which really interact) being much smaller than the number of negative ones.
Secondly the selection of negative examples can be based on some unreliable assumptions
which could introduce some bias in the classification results.
Here we propose the use of one-class classification (OCC) methods to deal with the task of
prediction of PPI. OCC methods utilise examples of just one class to generate a predictive
model which consequently is independent of the kind of negative examples selected; additionally
these approaches are known to cope with imbalanced class problems. We have
designed and carried out a performance evaluation study of several OCC methods for this
task, and have found that the Parzen density estimation approach outperforms the rest. We
also undertook a comparative performance evaluation between the Parzen OCC method
and several conventional learning techniques, considering different scenarios, for example
varying the number of negative examples used for training purposes. We found that the
Parzen OCC method in general performs competitively with traditional approaches and in
many situations outperforms them. Finally we evaluated the ability of the Parzen OCC
approach to predict new potential PPI targets, and validated these results by searching for
biological evidence in the literature
A preliminary investigation of trunk and wrist kinematics when using drivers with different shaft properties
It is unknown whether skilled golfers will modify their kinematics when using drivers of different shaft properties. This study aimed to firstly, determine if golf swing kinematics and swing parameters and related launch conditions differed when using modified drivers, then secondly, determine which kinematics were associated with clubhead speed. Twenty high level amateur male golfers (Mean ± SD: handicap = 1.9 ± 1.9 score) had their three-dimensional trunk and wrist kinematics collected for two driver trials. Swing parameters and related launch conditions were collected using a launch monitor. A one-way repeated measures ANOVA revealed significant (p ≤ 0.003) between-driver differences; specifically, faster trunk axial rotation velocity and an early wrist release for the low kick point driver. Launch angle was shown to be 2° lower for the high kick point driver. Regression models for both drivers explained a significant amount of variance (60 – 67%) in clubhead speed. Wrist kinematics were most associated with clubhead speed, indicating the importance of the wrists in producing clubhead speed regardless of driver shaft properties
Ecology and Thermal Inactivation of Microbes in and on Interplanetary Space Vehicle Components
Spores of Bacillus subtilis var. niger were heat treated in aqueous suspension at 90 C, and observed for morphological changes and loss of viability. The 5 logs reduction that occurred in broth at 90 min required 210 min in buffered water. Five characteristic changes observed after spores were exposed 120 min at 90 C in buffered water were: (1) 90% loss of spore viability, (2) 5% stainability, (3) 76% increase in spore size (as observed by scanning electron microscopy), (4) 21% of spore areas remaining refractile, and (5) an increase of 77% in packed cell volume (PCV). Stainability and PCV changes were recognized only after secondary exposure in broth. Extended heat exposure (3 h at 90 C) resulted in 99% loss of spore viability and 99% loss of stainability. After 4 hours of heat exposure, 90% of the cells disintegrated. These results suggest that early germinal changes occurr concurrently with the early changes in the heat susceptibility of dormant spores
Ecology and thermal inactivation of microbes in and on interplanetary space vehicle components
The experiments conducted to determine the heat resistance of Bacillus megaterium ATCC 6458 at 90 and 100 C were completed. Estimates from replicate experiments at eight percent relative humidities (less than 0.001 to 100% RH) for each temperature were computed. A Bacillus cereus strain with high heat resistance was cultured and the resistance determined in phosphate buffer (D sub 121.1 = 2.16 min and z = 8.7 C). The profile of the dry heat resistance of B. megaterium is summarized and the most resistant condition to the three spores (Bacillus subtilis var. niger, ATCC 29669, and Bacillus stearothermophilus, strain 1518) is compared
Ecology and thermal inactivation of microbes in and on interplanetary space vehicle components
Dry heat treatment is specified as the preferred means for the terminal sterilization of spacecraft and for decontamination of spacecraft components. The presence of organisms highly resistant to dry heat in soil and fallout around assembly and industrial manufacturing areas is shown. The dry heat survival characteristics of the Cape Kennedy isolate 4-6 B. brevis spores is demonstrated. The presence of hardy organisms from soil samples obtained from geographical areas of the United States is shown. A resistant fraction appears to occur in low numbers in a soil sample. The heat resistance characteristics of 4-6 B. brevis and B. subtilis var. niger spores are compared. Their morphological characteristics are compared by scanning electron microscopy
Ecology and thermal inactivation of microbes in and on interplanetary space vehicle components
Statistical techniques which have relevance to studies on the thermal inactivation on bacterial spores are discussed
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