Female Nurses In Private Sector: Their Problems And Prospects In Changing Scenario Of Challenging World

Nursing is a challenging job and issues arise that are out of your control. Some are direct results of communication and integrations amongst nurses. The study shows that, majority (75% )of the respondents opined that they have no mental stress for job pressure. While, about 12.5% of respondents opined they have mental stress at great extent. The sampling technique is simple random sampling which consist of 30 respondents randomly selected from a private hospital in Trivandrum district in Kerala with the tool consist of interview schedule. In general,Nurses of those females who face a lot of stress weather mental or physical are being pressurized by work. They are unable to devote time to their family and to themselves because of work and this leaves to disturbance between work and life further affecting their occupational life

ANALISA NILAI ARUS SETTING DAN WAKTU KERJA OVER CURRENT RELAY (OCR) TERHADAP GANGGUAN HUBUNG SINGKAT DI PENYULANG TRANSFORMATOR 7,5 MVA/13,8 kV PT. PUPUK SRIWIDJAJA PALEMBANG

Relay arus lebih atau lebih dikenal OCR (Over Current Relay) merupakan peralatan yang menysinyalir adanya arus lebih yang disebabkan oleh adanya gangguan hubung singkat atau over load yang dapat merusak peralatan sistem tenaga yang berbeda dalam wilayah proteksinya.Besarnya gangguan hubung singkatberbanding terbalik dengan jarak baik itu 3 fasa dan 2 fasa,karena semakin jauh jarak gangguan hubung singkat maka semakin kecil gangguan hubung singkat yang terjadi pada titik gangguan masing masing penyulang.Dan semakin dekat jarak gangguan singkat maka semakin kecil gangguan hubung singkat yang didapat.Besar nilai tms berdasarkan data dilapangan terlalu besar sehingga menyebabkan waktu kerja OCR menjadi lama.Sedangkan jika dibandingkan dengan nilai tms 0,1 maka waktu kerja OCR akan menjadi cepat dan efisien.Ditinjau dari jarak bahwasanya semakin dekat jarak titik gangguan hubung singkat maka semakin cepat waktu kerja OCR dan sebaliknya

Childhood motor performance is increased by participation in organized sport: the CHAMPS Study-DK

Evidence suggests that motor performance in children is declining globally. We tested whether participation in organized sport is associated with motor performance, and estimate the effect of 30 months participation in organized sport on motor performance. Study participants were 1067 primary school students, enrolled in the Danish Childhood Health, Activity, and Motor Performance School study. Participation in organized sport was reported via text messaging. Coordination-related motor performance composite, fitness-related motor performance composite, and total motor performance composite were calculated. Data were analyzed using Generalized Estimating Equations. Participation in organized sport was positively associated with motor performance (all composites) in models that did and did not control for baseline motor performance. For models that did not control for baseline motor performance, this equated to 2–6% increases in motor performance per weekly sport session; for models that did control for baseline motor performance, this equated to 1–5% increases in motor performance per weekly sport session. Positive associations between participation in organized sport and motor performance identify participation in organized sport as a way to improve motor performance in children. These results might provide the basis to determine whether participation in organized sport could be beneficial for children with developmental movement disorders

Receptor structure-based discovery of non-metabolite agonists for the succinate receptor GPR91

Besides functioning as an intracellular metabolite, succinate acts as a stress-induced extracellular signal through activation of GPR91 (SUCNR1) for which we lack suitable pharmacological tools.Here we first determined that the cis conformation of the succinate backbone is preferred and that certain backbone modifications are allowed for GPR91 activation. Through receptor modeling over the X-ray structure of the closely related P2Y1 receptor, we discovered that the binding pocket is partly occupied by a segment of an extracellular loop and that succinate therefore binds in a very different mode than generally believed. Importantly, an empty side-pocket is identified next to the succinate binding site. All this information formed the basis for a substructure-based search query, which, combined with molecular docking, was used in virtual screening of the ZINC database to pick two serial mini-libraries of a total of only 245 compounds from which sub-micromolar, selective GPR91 agonists of unique structures were identified. The best compounds were backbone-modified succinate analogs in which an amide-linked hydrophobic moiety docked into the side-pocket next to succinate as shown by both loss- and gain-of-function mutagenesis. These compounds displayed GPR91-dependent activity in altering cytokine expression in human M2 macrophages similar to succinate, and importantly were devoid of any effect on the major intracellular target, succinate dehydrogenase.These novel, synthetic non-metabolite GPR91 agonists will be valuable both as pharmacological tools to delineate the GPR91-mediated functions of succinate and as leads for the development of GPR91-targeted drugs to potentially treat low grade metabolic inflammation and diabetic complications such as retinopathy and nephropathy

Analysis and compensation for the effect of the catheter position on image intensities in intravascular optical coherence tomography

Cardiovascular Aspects of Radiolog

Dihydropyridine Fluorophores Allow for Specific Detection of Human Antibodies in Serum

Antigen recognition by antibodies plays an important role in human biology and in the development of diseases. This interaction provides a basis for multiple diagnostic assays and is a guide for treatments. We have developed dihydropyridine-based fluorophores that form stable complexes with double-stranded DNA and upon recognition of the antibodies to DNA (anti-DNA) provide an optical response. The fluorophores described herein have advantageous optical properties compared to those of the currently available dyes making them valuable for research and clinical diagnostics. By studying a series of novel fluorophores, crucial parameters for the design were established, providing the required sensitivity and specificity in the detection of antibodies. Using these DNA–fluorophore complexes in a direct immunofluorescence assay, antibodies to DNA are specifically detected in 80 patients diagnosed with an autoimmune disease, systemic lupus erythematosus. Positivity indicated by emission change of α-(4′-<i>O</i>-methoxyphenyl)-2-furyl dihydropyridine strongly correlates with other disease biomarkers and autoimmune arthritis

Discovery of a potent thiazolidine free fatty acid receptor 2 agonist with favorable pharmacokinetic properties

Free fatty acid receptor 2 (FFA2/GPR43) is a receptor for short-chain fatty acids reported to be involved in regulation of metabolism, appetite, fat accumulation and inflammatory responses, and is a potential target for treatment of various inflammatory and metabolic diseases. By bioisosteric replacement of the central pyrrolidine core of a previously disclosed FFA2 agonist with a synthetically more tractable thiazolidine, we were able to rapidly synthesize and screen analogues modified at both the 2- and 3-positions on the thiazolidine core. Herein, we report SAR exploration of thiazolidine FFA2 agonists and the identification of 31 (TUG-1375), a compound with significantly increased potency (7-fold in a cAMP assay) and reduced lipophilicity (50-fold reduced clogP) relative to the pyrrolidine lead structure. The compound has high solubility, high chemical, microsomal and hepatocyte stability, favorable pharmacokinetic properties, and was confirmed to induce human neutrophil mobilization and to inhibit lipolysis in murine adipocytes

Structure-activity relationship studies of tetrahydroquinolone free fatty acid receptor 3 modulators

Free fatty acid receptor 3 (FFA3, previously GPR41) is activated by short-chain fatty acids, mediates health effects of the gut microbiota, and is a therapeutic target for metabolic and inflammatory diseases. The shortage of well-characterized tool compounds has however impeded progress. Herein, we report structure–activity relationship of an allosteric modulator series and characterization of physicochemical and pharmacokinetic properties of selected compounds, including previous and new tools. Two representatives, 57 (TUG-1907) and 63 (TUG-2015), showed improved solubility and preserved potency. Of these, 57, with EC50 = 145 nM and a solubility of 33 μM, showed high clearance in vivo but is a preferred tool in vitro. In contrast, 63, with EC50 = 162 nM and a solubility of 9 μM, showed lower clearance and seems better suited for in vivo studies. Using 57, we demonstrate for the first time that FFA3 activation leads to calcium mobilization in murine dorsal root ganglia