Racial Bias in Elementary School Children: Effects of Skin Tone and Facial Features

This work examines whether explicit and implicit racial attitudes are driven primarily by skin tone, other features of facial physiognomy, or both in elementary school children (N = 108) between the ages of 5 and 12. Children evaluated faces varying in skin tone (from dark to light) and facial physiognomy (from Afrocentric to Eurocentric). In an explicit bias task, children rated how much they liked each face that appeared on the computer screen one by one. In an implicit bias task (a child-friendly version of the Affect Misattribution Procedure, Dunham & Emory, 2014), on each trial participants rated a Chinese character target as “good” or “bad” following a racial prime. In the explicit task, faces with darker skin tone and more Afrocentric faces were generally evaluated more negatively by both White and non-White children, which was especially true for darker skin tone faces with Eurocentric physiognomy. In addition, White children preferred faces with lighter skin tone while non-White children preferred faces with medium skin tone. Skin tone exerted a bigger influence than facial physiognomy on explicit attitudes. Results on the implicit task were more equivocal; reflecting an interactive relationship between participant race, skin tone and facial physiognomy. These findings provide evidence that pro-White attitudes (especially explicit) are driven by both factors, vary by race, and are present in both White and non-White children. There is emerging evidence that pro-White biases might be more internalized by non-White children in the American South

Regeneration Enhances Metastasis: A Novel Role for Neurovascular Signaling in Promoting Melanoma Brain Metastasis

Neural repair after stroke involves initiation of a cellular proliferative program in the form of angiogenesis, neurogenesis, and molecular growth signals in the surrounding tissue elements. This cellular environment constitutes a niche in which regeneration of new blood vessels and new neurons leads to partial tissue repair after stroke. Cancer metastasis has similar proliferative cellular events in the brain and other organs. Do cancer and CNS tissue repair share similar cellular processes? In this study, we identify a novel role of the regenerative neurovascular niche induced by stroke in promoting brain melanoma metastasis through enhancing cellular interactions with surrounding niche components. Repair-mediated neurovascular signaling induces metastatic cells to express genes crucial to metastasis. Mimicking stroke-like conditions in vitro displays an enhancement of metastatic migration potential and allows for the determination of cell-specific signals produced by the regenerative neurovascular niche. Comparative analysis of both in vitro and in vivo expression profiles reveals a major contribution of endothelial cells in mediating melanoma metastasis. These results point to a previously undiscovered role of the regenerative neurovascular niche in shaping the tumor microenvironment and brain metastatic landscape

What Drives Racial Attitudes in Elementary School Children: Skin Tone, Facial Physiognomy, or Both?

This work examines whether racial attitudes—when measured by both explicit and implicit measures— are driven primarily by skin tone, facial physiognomy, or both in 5 to 12-year-old children. Participants evaluated faces varying in skin tone (from dark to light) and facial physiognomy (from Afrocentric to Eurocentric). In an explicit task, children rated how much they liked each face. In an implicit task, participants completed a child-friendly version of the Affect Misattribution Procedure, where they rated a Chinese character as “good” or “bad” following a racial prime. Results suggest that pro-White attitudes (especially those measured by the explicit task) are driven by both factors, vary by perceivers’ race, and are present in both White and non-White children, though skin tone exerts a larger influence than other features, at least in explicit evaluations. Our results also raise the possibility that pro-White biases might be more internalized by non-White children in the American South

Regeneration Enhances Metastasis: A Novel Role for Neurovascular Signaling in Promoting Melanoma Brain Metastasis.

Neural repair after stroke involves initiation of a cellular proliferative program in the form of angiogenesis, neurogenesis, and molecular growth signals in the surrounding tissue elements. This cellular environment constitutes a niche in which regeneration of new blood vessels and new neurons leads to partial tissue repair after stroke. Cancer metastasis has similar proliferative cellular events in the brain and other organs. Do cancer and CNS tissue repair share similar cellular processes? In this study, we identify a novel role of the regenerative neurovascular niche induced by stroke in promoting brain melanoma metastasis through enhancing cellular interactions with surrounding niche components. Repair-mediated neurovascular signaling induces metastatic cells to express genes crucial to metastasis. Mimicking stroke-like conditions in vitro displays an enhancement of metastatic migration potential and allows for the determination of cell-specific signals produced by the regenerative neurovascular niche. Comparative analysis of both in vitro and in vivo expression profiles reveals a major contribution of endothelial cells in mediating melanoma metastasis. These results point to a previously undiscovered role of the regenerative neurovascular niche in shaping the tumor microenvironment and brain metastatic landscape