Inflammatory myofibroblastic tumor of the lung: a rare cause of atelectasis in children

Although rare, inflammatory myofibroblastic tumor is the most common primary lung mass in children. We report the case of an 11-year-old boy investigated for persistent cough and dyspnea with complete left lung atelectasis mimicking pneumonia. CT and MRI showed an endobronchial mass of the left main bronchus. The boy underwent endoscopic resection of the tumor and histology was in favor of an inflammatory myofibroblastic tumor of the lung. This diagnosis should be suspected in children with recurrent pneumonia. The prognosis is good after complete resectio

Expression de protéines induites après radiation ionisante dans les lignées cellulaires de cancer colorectal : une étude in vitro

Le traitement du cancer rectal associé à la résection chirurgicale une radiothérapie pré- ou postopératoire. Les tumeurs présentant différentes radiosensibilités, les patients sont exposés au risque de complications pour un bénéfice variable. Le but de cette étude est l'identification des modifications moléculaires, plus précisément, l'expression différentielle des protéines après un traitement de radiothérapie. Deux lignées cellulaires de cancer colorectal relativement radio-résistantes (DLD-1, HT-29) ont été irradiées. L'électrophorèse à deux dimensions combinée à une analyse informatique a permis de caractériser une expression différentielle de protéines et d'identifier certaines protéines. 266 spots (pl 4.40-7.67; 10'867-63'979 Dalton) furent visualisées. Après comparaison des deux lignées cellulaires, 18 profils de protéines sont différentiellement exprimés dans DLD-1 et HT-29. Nous avons identifié 3 protéines qui présentent une expression différentielle dans la lignée DLD-1, 11 dans HT-29 et 5 en commun. Ces protéines pourraient être impliquées dans la réponse cellulaire aux lésions d'ADN, expliquant possiblement leur relative radiorésistance

Inflammatory myofibroblastic tumor of the lung: a rare cause of atelectasis in children

Although rare, inflammatory myofibroblastic tumor is the most common primary lung mass in children. We report the case of an 11-year-old boy investigated for persistent cough and dyspnea with complete left lung atelectasis mimicking pneumonia. CT and MRI showed an endobronchial mass of the left main bronchus. The boy underwent endoscopic resection of the tumor and histology was in favor of an inflammatory myofibroblastic tumor of the lung. This diagnosis should be suspected in children with recurrent pneumonia. The prognosis is good after complete resection

Variabilidad individual de la acidosis ruminal en cabras lecheras

Variabilidad individual de la acidosis ruminal en cabras lecheras. AIDA (2017), 17. Jornadas obre Produccion Anima

Variability of rumen acidosis and intake behavior of dairy goats submitted to a dietary acidogenic challenge

Eight rumen cannulated dairy goats in early lactation (3.7 ± 0.2 kg/d) from the INRA-AgroParisTech experimental farm (Thiverval-Grignon, FR), were provided with wireless bolus sensors (KB1001 Kahne, Auckland, NZ) of pH and temperature to study the relationship between intake and subclinical acidosis for 35 d. After adapting to a TMR control diet (CO, 20% concentrate) for 12 d, goats were brusquely changed to an acidogenic diet (AC, 50% concentrate) for 23 d. Diets were fed ad libitum twice daily (a.m. 1/3, p.m. 2/3) according to milking intervals. Rumen pH and temperature data were captured every 15 min and intake measured every 2 min by weighing scales. Rumen samples were collected (h 0, 1, 2, 4 and 6 post feeding) to measure pH by pH-meter before (d 8 and 11) and after (d 13, 14, 15, 16, 20, 26 and 34) the change. One sensor failed and was discarded, the rest of data being modeled by logistic regression with Solver of Microsoft Excel. Data were analyzed by MIXED for repeated measurements and GLM procedures of SAS. Values of pH-meter vs. sensors correlated (r2 = 0.86; P < 0.01) and were used for sensor recalibration. Mean rumen pH varied markedly by hour and diet; on average, it was higher in CO vs. AC (6.34 ± 0.06 vs. 6.10 ± 0.03; P < 0.001). Despite the high concentrate percentage of AC diet, rumen pH was shortly under pH 6.0. Feed intake reached plateaus during the day when pH was closer to the a.m. or p.m. nadirs, and correlated negatively (r2 = 0.77 to 0.87; P < 0.01) during the periods in which pH dropped. Correlations between rumen temperature and pH were very poor (r2 < 0.1), except for the nightly resting period (r2 = 0.93; P < 0.001), the rumen being slightly colder in AC goats (CO vs. AC, 39.73 ± 0.09 vs. 39.61 ± 0.09°C; P < 0.001). Temperature and pH data from sensors fit logistic models (r2 = 0.97 to 0.99; P < 0.001). Pattern of pH logistic models and time spent under pH 6.0, allowed us to classify the goats as sensitive (3/7, 43%) or tolerant (4/7, 57%) to acidosis, which was related to individual feeding behavior. In conclusion, daily intake measurement and wireless sensors proved to be useful for monitoring rumen function, which allow for an individual separation of sensitive and tolerant goats to rumen acidosis

Dynamic data for determining the accuracy of four open-circuit respiration chambers designed to quantify methane emissions from goats

International audienceRespiration chambers are the gold standard technique for measuring methane in ruminants provided that their gas recovery rates are close to 100%. The determination of the gas recovery rate of respiration chamber facilities is a central prerequisite to assess the accuracy of the methane emission quantification. However, data of recovery tests are seldom reported. This paper presents data from gas recovery tests applied to an experimental facility of four open-circuit respiration chambers designed to measure methane emissions from goats. The experimental facility is located at Thiverval-Grignon, France. The recovery test was assessed by placing a known source of methane emission at six locations in each chamber successively. For each chamber, the gas from the chamber and the ambient air were continuously sampled by a Multi-Gas Analyser 3500 gas analyser provided with a multiport unit that switches the sampling between the pipe from chamber and from the ambient air every 90 s. The analyser determines the concentration (ppm) of methane by infrared. The data were further imported in an R script for calculation of the methane recovery percentage. These data are useful resources for illustrating the protocol to assess the accuracy of respiration chambers