A randomized feasibility trial comparing four antimalarial drug regimens to induce Plasmodium falciparum gametocytemia in the controlled human malaria infection model

Background: Malaria elimination strategies require a thorough understanding of parasite transmission from human to mosquito. A clinical model to induce gametocytes to understand their dynamics and evaluate transmission-blocking interventions (TBI) is currently unavailable. Here, we explore the use of the well-established Controlled Human Malaria Infection model (CHMI) to induce gametocyte carriage with different antimalarial drug regimens. Methods: In a single centre, open-label randomised tr

The Use of Controlled Human Malaria Infection As Fit-For-Purpose Model In The Fight Against Malaria

Contains fulltext : 217375.pdf (publisher's version ) (Open Access)Radboud University, 12 maart 2021Promotores : Sauerwein, R.W., Bousema, J.T.377 p

Biomarkers of cellular aging during a controlled human malaria infection

Cellular aging is difficult to study in individuals with natural infection, given the diversity of symptom duration and clinical presentation, and the high interference of aging-related processes with host and environmental factors. To address this challenge, we took advantage of the controlled human malaria infection (CHMI) model. This approach allowed us to characterize the relationship among cellular aging markers prior, during and post malaria pathophysiology in humans, controlling for infection dose, individual heterogeneity, previous exposure and co-infections. We demonstrate that already low levels of Plasmodium falciparum impact cellular aging by inducing high levels of inflammation and redox-imbalance; and that cellular senescence reversed after treatment and parasite clearance. This study provides insights into the complex relationship of telomere length, cellular senescence, telomerase expression and aging-related processes during a single malaria infection

Serologic Markers of Previous Malaria Exposure and Functional Antibodies Inhibiting Parasite Growth Are Associated With Parasite Kinetics Following a Plasmodium falciparum Controlled Human Infection

Contains fulltext : 221574.pdf (Publisher’s version ) (Open Access

Humoral protection against mosquito bite-transmitted Plasmodium falciparum infection in humanized mice

Contains fulltext : 189906.pdf (publisher's version ) (Open Access

Diagnosis and treatment based on quantitative PCR after controlled human malaria infection (vol 15, 398, 2016)

Immunogenetics and cellular immunology of bacterial infectious disease

Pre-clinical evaluation of a P. berghei-based whole-sporozoite malaria vaccine candidate

Contains fulltext : 199511.pdf (publisher's version ) (Open Access

A Plasmodium berghei sporozoite-based vaccination platform against human malaria

Contains fulltext : 195129.pdf (publisher's version ) (Open Access

Antibody Responses to Antigenic Targets of Recent Exposure Are Associated With Low-Density Parasitemia in Controlled Human Plasmodium falciparum Infections

Contains fulltext : 200896.pdf (publisher's version ) (Open Access