Acute hepatic effects of low-dose fumonisin b1 In rats

Adult male Wistar rats were enrolled in a study to test the acute hepatic effects of 50 mg/kg fumonisin B1 in feed for 5 days. Fumonisin B1 depressed growth and feed intake, and absolute and relative liver weight showed a significant increase. The proportions of C17:0, C18:3 n3, C22:5 n3 and C22:6 n3 fatty acids decreased in the hepatic phospholipid fraction. All proportional decreases modified the hepatocellular membrane lipids into a more rigid state. The fatty acid profile modifications were partly compensated for by endogenous glutathione (preventing the formation of conjugated dienes and trienes as initial phase lipid peroxidation indicators), while the enzymatic antioxidant defence system (glutathione peroxidase) was unaltered. In contrast, hepatic malondialdehyde, the cytotoxic product of end-phase lipid peroxidation showed a concentration increase even after 5 days of feeding. The results indicate a rather strong and rapid hepatic effect of FB1, immediately impairing membrane phospholipids, even before the enzymatic antioxidant defence is activated

The Attrition and Migration Behaviour among Hungarian Radiographers

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Can 18F-FDG PET/MR Imaging Contribute to the Assessment of Bone Lesions in Patients with Plasma Cell Dyscrasias?

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PET/MR in Relapsed Multiple Myeloma

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Comparison of changes in the liveweight and body composition of a newly developed cock line and TETRA-H chicks during the rearing period

The aim of this study was to follow the changes in the liveweight and in the muscle and fat tissue development of 60 chicks originated from a newly developed cock line and from the TETRA-H genotype. Changes in the body composition of these birds were examined by means of computer tomography (CT) in vivo. CT examinations were performed bi-weekly between 4 and 12 weeks of age. Overlapping 8 mm slice thickness measurements were performed covering the whole body of the chicken using a Siemens Somatom Emotion 6 multislice CT scanner. Using the images obtained so-called muscle and fat indices were calculated by determining the ratio of number of pixels with X-ray density values of muscle or fat to the total number of pixels with density values of muscle, water and fat, i.e. the range between -200 to +200 on the Hounsfield-scale. Based on the results, it was established that the liveweight of the chicks in the newly developed cock line was significantly higher at all examination days than that of the TETRA-H chicks. The difference between the two examined genotypes was more than 1 kg in the case of cocks and almost 1 kg in the case of pullets at 12 weeks of age. The ratio of muscle in the bird’s body was higher, while the ratio of fat lower in the case of the TETRA-H chicks at the end of the experiment in both sexes. Based on the results it was concluded that the use of the new cock line for improving the liveweight and meat production of the TETRA-H chicks can cause unfavourable changes in the body composition of the TETRA-H birds, which should be taken into consideration in the breeding programme of the TETRA-H hybrid in the future