The Effect of Regular Intake of Dry-Cured Ham Rich in Bioactive Peptides on Inflammation, Platelet and Monocyte Activation Markers in Humans.

Background and aims: Dietary studies have shown that active biopeptides provide protective health benefits, although the mediating pathways are somewhat uncertain. To throw light on this situation, we studied the effects of consuming Spanish dry-cured ham on platelet function, monocyte activation markers and the inflammatory status of healthy humans with pre-hypertension. Methods: Thirty-eight healthy volunteers with systolic blood pressure of >125 mmHg were enrolled in a two-arm crossover randomized controlled trial. Participants received 80 g/day dry-cured pork ham of >11 months proteolysis or 100 g/day cooked ham (control product) for 4 weeks followed by a 2-week washout before "crossing over" to the other treatment for 4 more weeks. Soluble markers and cytokines were analyzed by ELISA. Platelet function was assessed by measuring P-selectin expression and PAC-1 binding after ADP (adenosine diphosphate) stimulation using whole blood flow cytometry. Monocyte markers of the pathological status (adhesion, inflammatory and scavenging receptors) were also measured by flow cytometry in the three monocyte subsets after the interventional period. Results: The mean differences between dry-cured ham and cooked ham followed by a time period adjustment for plasmatic P-selectin and interleukin 6 proteins slightly failed (p = 0.062 and p = 0.049, respectively), notably increased for MCP-1 levels (p = 0.023) while VCAM-1 was not affected. Platelet function also decreased after ADP stimulation. The expression of adhesion and scavenging markers (ICAM1R, CXCR4 and TLR4) in the three subsets of monocytes was significantly higher (all p < 0.05). Conclusions: The regular consumption of biopeptides contained in the dry-cured ham but absent in cooked ham impaired platelet and monocyte activation and the levels of plasmatic P-selectin, MCP-1 and interleukin 6 in healthy subjects. This study strongly suggests the existence of a mechanism that links dietary biopeptides and beneficial health effects

WiFi-based urban localisation using CNNs

IEEE Conference on Intelligent Transportation Systems - ITSC 2019, 27-30/10/2019, Auckland, Nueva Zelanda.The continuous expanding scale of WiFi deployments in metropolitan areas has made possible to find WiFi access points at almost any place in our cities. Although WiFi has been mainly used for indoor localisation, there is a growing number of research in outdoor WiFi-based localisation. This paper presents a WiFi-based localisation system that takes advantage of the huge deployment of WiFi networks in urban areas. The idea is to complement localisation in zones where the GPS coverage is low, such as urban canyons. The proposed method explores the CNNs ability to handle large amounts of data and their high accuracy with reasonable computational costs. The final objective is to develop a system able to handle the large number of access points present in urban areas while preserving high accuracy and real time requirements. The system was tested in a urban environment, improving the accuracy with respect to the state-of-the-art and being able to work in real time

ROCK1 is a novel Rac1 effector to regulate tubular endocytic membrane formation during clathrin-independent endocytosis

Clathrin-dependent and -independent pathways contribute for β1-integrin endocytosis. This study defines a tubular membrane clathrin-independent endocytic network, induced with the calmodulin inhibitor W13, for β1-integrin internalization. This pathway is dependent on increased phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) levels and dynamin activity at the plasma membrane. Exogenous addition of PI(4,5)P2 or phosphatidylinositol-4-phosphate 5-kinase (PIP5K) expression mimicked W13-generated-tubules which are inhibited by active Rac1. Therefore, the molecular mechanisms downstream of Rac1, that controls this plasma membrane tubulation, were analyzed biochemically and by the expression of different Rac1 mutants. The results indicate that phospholipase C and ROCK1 are the main Rac1 effectors that impair plasma membrane invagination and tubule formation, essentially by decreasing PI(4,5)P2 levels and promoting cortical actomyosin assembly respectively. Interestingly, among the plethora of proteins that participate in membrane remodeling, this study revealed that ROCK1, the well-known downstream RhoA effector, has an important role in Rac1 regulation of actomyosin at the cell cortex. This study provides new insights into Rac1 functioning on plasma membrane dynamics combining phosphatidylinositides and cytoskeleton regulation

Fail-aware LIDAR-based odometry for autonomous vehicles

Autonomous driving systems are set to become a reality in transport systems and, so, maximum acceptance is being sought among users. Currently, the most advanced architectures require driver intervention when functional system failures or critical sensor operations take place, presenting problems related to driver state, distractions, fatigue, and other factors that prevent safe control. Therefore, this work presents a redundant, accurate, robust, and scalable LiDAR odometry system with fail-aware system features that can allow other systems to perform a safe stop manoeuvre without driver mediation. All odometry systems have drift error, making it difficult to use them for localisation tasks over extended periods. For this reason, the paper presents an accurate LiDAR odometry system with a fail-aware indicator. This indicator estimates a time window in which the system manages the localisation tasks appropriately. The odometry error is minimised by applying a dynamic 6-DoF model and fusing measures based on the Iterative Closest Points (ICP), environment feature extraction, and Singular Value Decomposition (SVD) methods. The obtained results are promising for two reasons: First, in the KITTI odometry data set, the ranking achieved by the proposed method is twelfth, considering only LiDAR-based methods, where its translation and rotation errors are 1.00% and 0.0041 deg/m, respectively. Second, the encouraging results of the fail-aware indicator demonstrate the safety of the proposed LiDAR odometry system. The results depict that, in order to achieve an accurate odometry system, complex models and measurement fusion techniques must be used to improve its behaviour. Furthermore, if an odometry system is to be used for redundant localisation features, it must integrate a fail-aware indicator for use in a safe manner

Emotional Processing Profile in Patients with First Episode Schizophrenia:The Influence of Neurocognition

This study sought to investigate the influence of neurocognition on the emotional processing profiles of patients with first-episode schizophrenia, using the 4-branch Mayer-Salovey-Caruso Emotional Intelligence Test (MSCEIT) (Perceiving Emotions; Facilitating Emotions; Understanding Emotions and Managing Emotions). A sample of 78 patients with first-episode schizophrenia and a group of 90 non-psychiatric control subjects were included in this work. The initial results showed that patients had lower scores than controls for the "Understanding Emotions" and "Managing Emotions" MSCEIT branches. However, after controlling for neurocognition, the only deficits were found on the "Managing Emotions" branch of the MSCEIT. This branch can be considered as measuring a more sophisticated level of emotional processing, which may constitute a deficit in itself. In conclusion, patients with first-episode schizophrenia present deficits in social cognition at the highest level that seem to be independent from neurocognition. These findings support the inclusion of the "Managing Emotions" branch of the MSCEIT as part of the MCCB.Instituto de Salud Carlos III (PI16/00359)Instituto de Salud Carlos III (PI19/00766)Comunidad de Madrid (S2017/BMD-3740)Ministry of Health (MOH-000013)4.242 JCR (2020) Q1, 39/167 Medicine, general & internal1.040 SJR (2021) Q1, 438/2489 Medicine (miscellaneous)No data IDR 2020UE

Nave industrial para acopio de materia prima en industria de estructura metálica (Polígono Las Capellanías)

Este Trabajo de Fin de Grado tiene como objeto el estudio, definición y valoración de las obras necesarias para la construcción de una nave industrial para acopio de materia prima en industria de estructura metálica en el polígono industrial Las Capellanías de Cáceres, en la parcela del número 102 de la Calle Molineros.Grado en Ingeniería Civil - Construcciones Civiles. Universidad de Extremadur

Nave industrial para acopio de materia prima en industria de estructura metálica (Polígono Las Capellanías)

Este Trabajo de Fin de Grado tiene como objeto el estudio, definición y valoración de las obras necesarias para la construcción de una nave industrial para acopio de materia prima en industria de estructura metálica en el polígono industrial Las Capellanías de Cáceres, en la parcela del número 102 de la Calle Molineros.Grado en Ingeniería Civil - Construcciones Civiles. Universidad de Extremadur

Pérdida de audición no orgánica. A propósito de un caso

La sordera de origen no orgánico ha sido objeto de estudio por parte de otorrinolaringología con el fin de establecer un diagnóstico certero. Sin embargo, pocos artículos versan sobre la salud mental del sujeto que la sufre. Entre las causas subyacentes se diferencian el trastorno por conversión, trastorno facticio y la simulación. En el presente artículo se expone el caso de una mujer cuyo malestar emocional esbozará variopintos síntomas conversivos, destacando la pérdida de audición por su relativa infrecuencia. Se expondrán las dificultades encontradas en su diagnóstico clínico y manejo terapéutico. Se pondrá en evidencia la importancia de trabajar conjuntamente con el resto de especialistas y entorno más cercano de la paciente