Ruthenium-Catalyzed Asymmetric Reduction of Isoxazolium Salts: Access to Optically Active Δ⁴‑Isoxazolines

A tethered MsDPEN–ruthenium catalyst reduces a series of isoxazolium salts, affording optically active Δ⁴-isoxazolines in moderate to good yields and enantioenrichment. The redundancy of heating or high pressures allowed for chemoselective reduction with no subsequent heterocyclic ring opening. Our results reinforce our understanding of the workings of these Noyori-class catalysts

Asymmetric Synthesis of Enaminophosphines via Palladacycle-Catalyzed Addition of Ph₂PH to α,β-Unsaturated Imines

A highly reactive, chemo- and enantioselective addition of diphenylphosphine to α,β-unsaturated imines catalyzed by a palladacycle has been developed, thus providing the access to a series of chiral tertiary enaminophosphines in high yields. A putative catalytic cycle has also been proposed

Asymmetric Synthesis of Enaminophosphines via Palladacycle-Catalyzed Addition of Ph₂PH to α,β-Unsaturated Imines

A highly reactive, chemo- and enantioselective addition of diphenylphosphine to α,β-unsaturated imines catalyzed by a palladacycle has been developed, thus providing the access to a series of chiral tertiary enaminophosphines in high yields. A putative catalytic cycle has also been proposed