Asymmetric Synthesis of Enaminophosphines via Palladacycle-Catalyzed Addition of Ph₂PH to α,β-Unsaturated Imines

Abstract

A highly reactive, chemo- and enantioselective addition of diphenylphosphine to α,β-unsaturated imines catalyzed by a palladacycle has been developed, thus providing the access to a series of chiral tertiary enaminophosphines in high yields. A putative catalytic cycle has also been proposed