Negative ion Time Projection Chamber operation with SF6_{6} at nearly atmospheric pressure

We present measurements of drift velocities and mobilities of some innovative negative ion gas mixtures at nearly atmospheric pressure based on SF$_{6}$ as electronegative capture agent and of pure SF$_{6}$ at various pressures, performed with the NITEC detector. NITEC is a Time Projection Chamber with 5 cm drift distance readout by a GEMPix, a triple thin GEMs coupled to a Quad-Timepix chip, directly sensitive to the deposited charge on each of the 55 $\times$ 55 $\mu$m$^2$ pixel. Our results contribute to expanding the knowledge on the innovative use of SF$_{6}$ as negative ion gas and extend to triple thin GEMs the possibility of negative ion operation for the first time. Above all, our findings show the feasibility of negative ion operation with He:CF$_4$:SF$_{6}$ at 610 Torr, opening extremely interesting possibility for next generation directional Dark Matter detectors at 1 bar

Targeting RAGE prevents muscle wasting and prolongs survival in cancer cachexia

Background: Cachexia, a multifactorial syndrome affecting more than 50% of patients with advanced cancer and responsible for ~20% of cancer-associated deaths, is still a poorly understood process without a standard cure available. Skeletal muscle atrophy caused by systemic inflammation is a major clinical feature of cachexia, leading to weight loss, dampening patients' quality of life, and reducing patients' response to anticancer therapy. RAGE (receptor for advanced glycation end-products) is a multiligand receptor of the immunoglobulin superfamily and a mediator of muscle regeneration, inflammation, and cancer. Methods: By using murine models consisting in the injection of colon 26 murine adenocarcinoma (C26-ADK) or Lewis lung carcinoma (LLC) cells in BALB/c and C57BL/6 or Ager−/− (RAGE-null) mice, respectively, we investigated the involvement of RAGE signalling in the main features of cancer cachexia, including the inflammatory state. In vitro experiments were performed using myotubes derived from C2C12 myoblasts or primary myoblasts isolated from C57BL/6 wild type and Ager−/− mice treated with the RAGE ligand, S100B (S100 calcium-binding protein B), TNF (tumor necrosis factor)α±IFN (interferon) γ, and tumour cell- or masses-conditioned media to analyse hallmarks of muscle atrophy. Finally, muscles of wild type and Ager−/− mice were injected with TNFα/IFNγ or S100B in a tumour-free environment. Results: We demonstrate that RAGE is determinant to activate signalling pathways leading to muscle protein degradation in the presence of proinflammatory cytokines and/or tumour-derived cachexia-inducing factors. We identify the RAGE ligand, S100B, as a novel factor able to induce muscle atrophy per se via a p38 MAPK (p38 mitogen-activated protein kinase)/myogenin axis and STAT3 (signal transducer and activator of transcription 3)-dependent MyoD (myoblast determination protein 1) degradation. Lastly, we found that in cancer conditions, an increase in serum levels of tumour-derived S100B and HMGB1 (high mobility group box 1) occurs leading to chronic activation/overexpression of RAGE, which induces hallmarks of cancer cachexia (i.e. muscle wasting, systemic inflammation, and release of tumour-derived pro-cachectic factors). Absence of RAGE in mice translates into reduced serum levels of cachexia-inducing factors, delayed loss of muscle mass and strength, reduced tumour progression, and increased survival. Conclusions: RAGE is a molecular determinant in inducing the hallmarks of cancer cachexia, and molecular targeting of RAGE might represent a therapeutic strategy to prevent or counteract the cachectic syndrome

Mobile customer relationship management : An explorative investigation of the italian consumer market

Mobile customer relationship management (CRM) services seem to have all the characteristics commonly associated with successful mobile services and have accordingly been predicted to be among the most promising. However, real development of this sector has not been well explored so far, especially in relation to the actual supply of mobile CRM services to the public. The purpose of this paper is to reduce this gap by giving a first snapshot of the current development of the supply of mobile CRM services to consumers taken in the context of the Italian market. In order to do so, it firstly proposes a conceptual framework indicating the relevant aspects to investigate for assessing this kind of environments: the market, value propositions, actors and issues. Then it applies this framework to get an overview of the supply of mobile CRM services in Italy and provides some empirical insight about its current development obtained through an exhaustive survey of the current supply of 750 services from 353 firms

Carbon nanotubes as target for directional detection of light WIMP

In this paper I will briefly introduce the idea of using Carbon Nanotubes (CNT) as target for the detection of low mass WIMPs with the additional information of directionality. I will also present the experimental efforts of developing a Time Projection Chamber with a CNT target inside and the results of a test beam at the Beam Test Facility of INFN-LNF.Comment: 3 figures, IFAE2017 poster session proceeding

Investigating The Physics Case of Running a B-Factory at the Y(5S) Resonance

We discuss the physics case of a high luminosity B-Factory running at the Y(5S) resonance. We show that the coherence of the B meson pairs is preserved at this resonance, and that Bs can be well distinguished from Bd and charged B mesons. These facts allow to cover the physics program of a traditional B-Factory and, at the same time, to perform complementary measurements which are not accessible at the Y(4S). In particular we show how, despite the experimental limitations in performing time-dependent measurements of Bs decays, the same experimental information can be extracted, in several cases, from the determination of time-integrated observables. In addition, a few examples of the potentiality in measuring rare Bs decays are given. Finally, we discuss how the study of Bs meson will improve the constraints on New Physics parameters in the Bs sector, in the context of the generalized Unitarity Triangle analysis.Comment: 47 pages, 22 figure

ULTRALIGHT RADAR FOR SMALL AND MICRO-UAV NAVIGATION

This paper presents a radar approach to navigation of small and micro Unmanned Aerial Vehicles (UAV) in environments challenging for common sensors. A technique based on radar odometry is briefly explained and schemes for complete integration with other sensors are proposed. The focus of the paper is set on ultralight radars and interpretation of outputs of such sensor when dealing with autonomous navigation in complex scenario. The experimental setup used to analyse the proposed approach comprises one multi-rotor UAV and one ultralight commercial radar. Results from flight tests in which both forward-only motion and mixed motion are presented and analysed, providing a reference for understanding outputs of radar in complex scenarios. The radar odometry solution is compared with ground truth provided by GPS sensor

Which competences and what managerial training for the health professions

The process of passage to be e-profit and loss organization following the reform of the Italian health system, especially in a context of fiscal federalism and administered competition among the public and private producers, causes implications on the competences of whom develops his/her own professional activity. The aim of the paper is to give some inputs for discussion about the training of manager: starting from the meaning of the word ?management? and using the model elaborated by Mintzberg and Simon with the purpose to identify who is involved in such training, trying to make explicit that the analysis of the organizational positions and the profile of the resource that will go to occupy it is a forced passage for building the training package and to make clear characteristics and contents of the training offer

ULTRALIGHT RADAR FOR SMALL AND MICRO-UAV NAVIGATION

This paper presents a radar approach to navigation of small and micro Unmanned Aerial Vehicles (UAV) in environments challenging for common sensors. A technique based on radar odometry is briefly explained and schemes for complete integration with other sensors are proposed. The focus of the paper is set on ultralight radars and interpretation of outputs of such sensor when dealing with autonomous navigation in complex scenario. The experimental setup used to analyse the proposed approach comprises one multi-rotor UAV and one ultralight commercial radar. Results from flight tests in which both forward-only motion and mixed motion are presented and analysed, providing a reference for understanding outputs of radar in complex scenarios. The radar odometry solution is compared with ground truth provided by GPS sensor

Drivers involved in road traffic accidents in Piedmont Region: psychoactive substances consumption

Introduction. The role played by psychoactive substances in road safety has become object of increasing interest: these substances can reduce driving performance and increase accidents risk. Aims of the study are to establish the dimension of the problem and to describe the characteristics of people involved in accidents under psychoactive substance effects. Methods. Target population consists of people from 18 to 60 years old involved in accidents afferent in Emergency Rooms. Subjects were interviewed by surveyors and a urines was collected for psychoactive substances screening. Results. In 18.5% of people we found substance consumption. Cocaine was the most frequently detected substance (9.5%), then benzodiazepines (7.5%), methadone, morphine and marijuana (THC) (3.5%). In 5.5% of subjects more then one substance was found. Considering only illegal substances detected, female have a higher risk to be consumers (OR = 1.36) and the young age (18-35 years) seems to be at higher prevalence and risk for substance use (OR = 1.86). Discussion. Considering all psychoactive substances detected, clearly the problem about substances consumption and driving is not restricted to youngest but involves all age groups. Conclusions. In order to decrease the number of accidents due to substance use, new prevention programmes able to involve also middle age groups should be planned