Distribution and Conservation Status of Antillean Manatees (Trichechus manatus manatus) in Honduras

The Antillean manatee, Trichechus manatus manatus, is among the most threatened mammals in Honduras, yet the last published study is from 1980. Since then, the North Coast of Honduras has experienced rapid population growth and land cover change possibly causing habitat loss for manatees. We conducted aerial, boat, and interview surveys between 2005-2007 along the northern and remote eastern coasts of Honduras to assess the current status and distribution of manatees. In addition, we compiled all available data on manatee mortality from museum specimens, unpublished reports, and interviews to determine current threats. We averaged 1.2 manatee sightings per survey hour during six flights along the North Coast in March-April 2006 during 14.4 aerial survey hours. Sightings were mainly clustered in Cuero y Salado Wildlife Refuge (CSWR) and Rios Chapagua and Aguan, which we indentify as important conservation areas. Our total and average sightings per survey hour in CSWR were much lower than those reported in 1979-80, in spite of the area being protected since 1987. Our interviews indicate that manatees are still present on the eastern coast (La Mosquitia), however we observed none during 14.5 survey hours in June 2005 and April 2007. The major cause of known mortality from 1970-2007, based on 26 records, was due to entanglement in fishnets. Despite local and federal protection, manatees are still poached and opportunistically caught in fishnets. While some efforts have been made by local NGOs to raise public awareness for manatees, a national conservation program is highly recommended to centralize and coordinate efforts

Distribution and conservation status of the Antillean manatee (Trichechus manatus manatus) in Honduras

The Antillean manatee, Trichechus manatus manatus, is among the most threatened mammals in Honduras, yet the last published study is from 1980. Since then, the North Coast of Honduras has experienced rapid population growth and land cover change possibly causing habitat loss for manatees. We conducted aerial, boat, and interview surveys between 2005-2007 along the northern and remote eastern coasts of Honduras to assess the current status and distribution of manatees. In addition, we compiled all available data on manatee mortality from museum specimens, unpublished reports, and interviews to determine current threats. We averaged 1.2 manatee sightings per survey hour during six flights along the North Coast in March-April 2006 during 14.4 aerial survey hours. Sightings were mainly clustered in Cuero y Salado Wildlife Refuge (CSWR) and Rios Chapagua and Aguan, which we indentify as important conservation areas. Our total and average sightings per survey hour in CSWR were much lower than those reported in 1979-80, in spite of the area being protected since 1987. Our interviews indicate that manatees are still present on the eastern coast (La Mosquitia), however we observed none during 14.5 survey hours in June 2005 and April 2007. The major cause of known mortality from 1970-2007, based on 26 records, was due to entanglement in fishnets. Despite local and federal protection, manatees are still poached and opportunistically caught in fishnets. While some efforts have been made by local NGOs to raise public awareness for manatees, a national conservation program is highly recommended to centralize and coordinate efforts

Extensive identification of genes involved in congenital and structural heart disorders and cardiomyopathy

Clinical presentation of congenital heart disease is heterogeneous, making identification of the disease-causing genes and their genetic pathways and mechanisms of action challenging. By using in vivo electrocardiography, transthoracic echocardiography and microcomputed tomography imaging to screen 3,894 single-gene-null mouse lines for structural and functional cardiac abnormalities, here we identify 705 lines with cardiac arrhythmia, myocardial hypertrophy and/or ventricular dilation. Among these 705 genes, 486 have not been previously associated with cardiac dysfunction in humans, and some of them represent variants of unknown relevance (VUR). Mice with mutations in Casz1, Dnajc18, Pde4dip, Rnf38 or Tmem161b genes show developmental cardiac structural abnormalities, with their human orthologs being categorized as VUR. Using UK Biobank data, we validate the importance of the DNAJC18 gene for cardiac homeostasis by showing that its loss of function is associated with altered left ventricular systolic function. Our results identify hundreds of previously unappreciated genes with potential function in congenital heart disease and suggest causal function of five VUR in congenital heart disease