Averaged T1-weighted MPRAGE with an isotropic resolution of 250 µm

This folder contains structural data of a single young healthy Caucasian subject in NIfTI file format. This dataset has been build by registering eight single T1-weighted MPRAGE volumes with a native isotropic resolution of 250 µm and the average to increase the SNR

Sourcedata of T1-weighted MPRAGE volumes

This folder contains all eight single unprocessed T1-weighted MPRAGE volumes used to generate the average with an isotropic resolution of 250 µm. Additionally, 1 and 0.5 mm unprocessed data of the same subject and motion tracking information of all acquisitions is included in the archive

Pre-Processed T1-weighted MPRAGE volumes

This folder contains all eight single pre-processed T1-weighted MPRAGE volumes used to generate the average with an isotropic resolution of 250 µm. Additionally, 1 and 0.5 mm pre-processed data of the same subject are included in the folder. Pre-processing consists of AC-PC alignment and bias field correction. Details can be found in the readme

Data_Sheet_1_Midlife occupational cognitive requirements protect cognitive function in old age by increasing cognitive reserve.pdf

IntroductionSeveral lifestyle factors promote protection against Alzheimer's disease (AD) throughout a person's lifespan. Although such protective effects have been described for occupational cognitive requirements (OCR) in midlife, it is currently unknown whether they are conveyed by brain maintenance (BM), brain reserve (BR), or cognitive reserve (CR) or a combination of them.MethodsWe systematically derived hypotheses for these resilience concepts and tested them in the population-based AgeCoDe cohort and memory clinic-based AD high-risk DELCODE study. The OCR score (OCRS) was measured using job activities based on the O*NET occupational classification system. Four sets of analyses were conducted: (1) the interaction of OCR and APOE-ε4 with regard to cognitive decline (N = 2,369, AgeCoDe), (2) association with differentially shaped retrospective trajectories before the onset of dementia of the Alzheimer's type (DAT; N = 474, AgeCoDe), (3) cross-sectional interaction of the OCR and cerebrospinal fluid (CSF) AD biomarkers and brain structural measures regarding memory function (N = 873, DELCODE), and (4) cross-sectional and longitudinal association of OCR with CSF AD biomarkers and brain structural measures (N = 873, DELCODE).ResultsRegarding (1), higher OCRS was associated with a reduced association of APOE-ε4 with cognitive decline (mean follow-up = 6.03 years), consistent with CR and BR. Regarding (2), high OCRS was associated with a later onset but subsequently stronger cognitive decline in individuals converting to DAT, consistent with CR. Regarding (3), higher OCRS was associated with a weaker association of the CSF Aβ42/40 ratio and hippocampal volume with memory function, consistent with CR. Regarding (4), OCR was not associated with the levels or changes in CSF AD biomarkers (mean follow-up = 2.61 years). We found a cross-sectional, age-independent association of OCRS with some MRI markers, but no association with 1-year-change. OCR was not associated with the intracranial volume. These results are not completely consistent with those of BR or BM.DiscussionOur results support the link between OCR and CR. Promoting and seeking complex and stimulating work conditions in midlife could therefore contribute to increased resistance to pathologies in old age and might complement prevention measures aimed at reducing pathology.</p