Biologics for the treatment of chronic rhinosinusitis with nasal polyps : state of the art

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a complex upper airway disease affecting up to 11% of the population of Western Europe. In these western countries, 85% of the CRSwNP disease reveals a type 2 inflammatory pattern. In the last 15 years, several randomized double-blind studies on monoclonal antibodies in CRSwNP were performed. These studies demonstrated for the first time that biologics targeting type 2 immune reactions might be successful in nasal polyps. The target proteins, interleukin (IL)-4, IL-5, IL-13, and IgE were previously identified as key mediators in studies using nasal polyp tissues to measure and to interact in ex-vivo settings. No biomarkers have been identified to predict response to a specific biologic or to monitor treatment success. These studies were characterized by small numbers of patients and heterogeneous populations. They did, however, pave the way for currently performed and analyzed phase 3 studies, which will possibly lead to the registration of the first biologic drug with the indication CRSwNP. The studies already provide indications on the effects to be expected from those biologics; the results of phase-3 studies in larger populations will be decisive for the indications, patient selection, and finally the stopping rules for those drugs in subjects with severe nasal polyps, in whom the current standard of care including topical and oral glucocorticosteroids, antibiotics and surgical procedures failed to control the disease. We may expect that those biologics will open new perspectives for those patients with severe polyposis with, but also independent of asthma, allowing to avoid the possible adverse events resulting from systemic glucocorticosteroids and surgery

Confined Multilamellae Prefer Cylindrical Morphology

By evaporating a drop of lipid dispersion we generate the myelin morphology often seen in dissolving surfactant powders. We explain these puzzling nonequilibrium structures using a geometric argument: The bilayer repeat spacing increases and thus the repulsion between bilayers decreases when a multilamellar disk is converted into a myelin without gain or loss of material and with number of bilayers unchanged. Sufficient reduction in bilayer repulsion can compensate for the cost in curvature energy, leading to a net stability of the myelin structure. A numerical estimate predicts the degree of dehydration required to favor myelin structures over flat lamellae.Comment: 6 pages, 3 figures, submitted to Euro. Phys. J.

Antibacterial Performance of a Cu-bearing Stainless Steel against Microorganisms in Tap Water

This document is the Accepted Manuscript of the following article: Mingjun Li, Li Nan, Dake xu, Guogang Ren, Ke Yang, ‘Antibacterial Performance of a Cu-bearing Stainless Steel against Microorganisms in Tap Water’, Journal of Materials Science & Technology, Vol. 31 (3): 243-251, March 2015, DOI: https://doi.org/10.1016/j.jmst.2014.11.016, made available under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License CC BY NC-ND 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).Tap water is one of the most commonly used water resources in our daily life. However, the increasing water contamination and the health risk caused by pathogenic bacteria, such as Staphylococcus aureus and Escherichia coli have attracted more attention. The mutualism of different pathogenic bacteria may diminish antibacterial effect of antibacterial agents. It was found that materials used for making pipe and tap played one of the most important roles in promoting bacterial growth. This paper is to report the performance of an innovative type 304 Cu-bearing stainless steel (304CuSS) against microbes in tap water. The investigation methodologies involved were means of heterotrophic plate count, contact angle measurements, scanning electron microscopy for observing the cell and subtract surface morphology, atomic absorption spectrometry for copper ions release study, and confocal laser scanning microscopy used for examining live/dead bacteria on normal 304 stainless steel and 304CuSS. It was found that the surface free energy varied after being immersed in tap water with polar component and Cu ions release. The results showed 304CuSS could effectively kill most of the planktonic bacteria (max 95.9% antibacterial rate), and consequently inhibit bacterial biofilms formation on the surface, contributing to the reduction of pathogenic risk to the surrounding environments.Peer reviewe

Observation and Understanding of the Initial Unstable Electrical Contact Behaviors

Reliable and long-lifetime electrical contact is a very important issue in the field of radio frequency microelectromechanical systems (MEMS) and in energy transmission applications. In this paper, the initial unstable electrical contact phenomena under the conditions of micro-newton-scale contact force and nanometer-scale contact gap have been experimentally observed. The repetitive contact bounces at nanoscale are confirmed by the measured instantaneous waveforms of contact force and contact voltage. Moreover, the corresponding physical model for describing the competition between the electrostatic force and the restoring force of the mobile contact is present. Then, the dynamic process of contact closure is explicitly calculated with the numerical method. Finally, the effects of spring rigidness and open voltage on the unstable electrical contact behaviors are investigated experimentally and theoretically. This paper highlights that in MEMS systems switch, minimal actuation velocity is required to prevent mechanical bounce and excessive wear