164 research outputs found
Synthesis and cation-receptor properties of macrocyclic imines of anthraquinone
At the present study a series of crown-containing imines of 1-hydroxy-9,10-anthraquinone with donor and acceptor substituents at the anthraquinone nucleus were synthesized. Compounds were prepared photochemically from the corresponding photoactive 1-phenoxyanthraquinones and 4-aminobenzo-15-crown-5 ether. It was established spectrophotometrically that for crown-containing anthraquinone imines that are characterized by "imine-enamine" prototropic tautomerism, the insertion of acceptor substituents shifts the equilibrium to the "enamine" form. This shift leads to essential spectral changes in complexing chlor- and nitrocontaining macrocyclic imines of anthraquinone with alkali and alkaline-earth metal cations
GluK2-mediated excitability within the superficial layers of the entorhinal cortex
11 pages, 6 pages.-- PMID: 19440371 [PubMed].-- PMCID: PMC2679203.-- Supporting information available:ο»Ώ Figure S1, doi:10.1371/journal.pone.0005576.s001 (0.63 MB TIF).Recent analysis of genetically modified mice deficient in different kainate receptor (KAR) subunits have strongly pointed to a role of the GluK2 subunit, mediating the vulnerability of the brain towards seizures. Research concerning this issue has focused mainly on the hippocampus. However, several studies point to a potential role of other parts of the hippocampal formation, in particular the entorhinal cortex, in the development of epileptic seizures. There is extensive cell death after such seizures in layer III of the medial entorhinal cortex (LIII mEC), making this region of special interest for investigation into related pathological conditions. We therefore characterized KAR mediated currents in LIII mEC pyramidal neurons by several different approaches. Using patch-clamp technique, in combination with glutamate uncaging in horizontal brain slices, we show that LIII mEC neurons exhibit KAR currents. Use of genetically modified mice reveal that these currents are mediated by GluK2 containing KARs. The IV curve indicates the predominant presence of a Ca2+ impermeable and edited form of the KAR. Finally, we show that GluK2 containing kainate receptors are essential for kainate-induced gamma oscillations within the entorhinal cortex.ο»ΏThis study has been funded by the SFB 665 grant and P.B. is a member of and funded by the GRK 1123.Peer reviewe
SOME ASPECTS OF ENERGY SAVING OF BURDEN MATERIAL IN THE BLAST FURNACE
To determine the possibility of self-stabilization effect for burden
surface texture and gas flow in operating blast furnace under the proper conditions
was experimentally proved for the first time, as well as the reasons of the effect
disruption
Improvement of the approaches to improve the health of the population in the regions of Russia
Significant differentiation of socio-economic indicators of the subjects of the Russian Federation indicates significant regional differences in the initial conditions of demographic development. The aim of the study is to develop measures to improve the policy in the field of public health at the regional level in Russia, taking into account the factors of formation of public health. We conducted a factor analysis of the socio-economic situation in the regions, followed by clustering on the basis of a list of selected statistical indicators, which allowed us to develop common approaches to improving health policy for each group of subjects of the Russian Federation, taking into account their main historical, geographical and socioeconomic characteristics
ΠΠΎΠΌΠΏΠ»Π΅ΠΊΡ Π³Π΅ΠΎΡΠΈΠ·ΠΈΡΠ΅ΡΠΊΠΈΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ Π² ΠΎΡΠΊΡΡΡΠΎΠΌ ΡΡΠ²ΠΎΠ»Π΅ ΡΠΊΠ²Π°ΠΆΠΈΠ½Ρ Ρ ΡΠ΅Π»ΡΡ ΠΎΡΠ΅Π½ΠΊΠΈ Π½Π΅ΡΡΠ΅Π³Π°Π·ΠΎΠ½ΠΎΡΠ½ΠΎΡΡΠΈ ΡΠ°Π·ΡΠ΅Π·ΠΎΠ² ΠΡΡΠ»ΠΎΠ²ΡΠΊΠΎΠΉ ΡΡΡΡΠΊΡΡΡΡ (Π’ΠΎΠΌΡΠΊΠ°Ρ ΠΎΠ±Π»Π°ΡΡΡ)
ΠΠ° ΠΎΡΠ½ΠΎΠ²Π΅ Π°Π½Π°Π»ΠΈΠ·Π° ΡΠ°Π½Π΅Π΅ Π²ΡΠΏΠΎΠ»Π½Π΅Π½Π½ΡΡ
Π³Π΅ΠΎΠ»ΠΎΠ³ΠΎ-Π³Π΅ΠΎΡΠΈΠ·ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ, Π²ΡΠΏΠΎΠ»Π½Π΅Π½ ΠΏΡΠΎΠ΅ΠΊΡ Π½Π° ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ° Π³Π΅ΠΎΡΠΈΠ·ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΡΠΊΠ²Π°ΠΆΠΈΠ½ Π² ΠΎΡΠΊΡΡΡΠΎΠΌ ΡΡΠ²ΠΎΠ»Π΅ ΡΠΊΠ²Π°ΠΆΠΈΠ½Ρ ΠΡΡΠ»ΠΎΠ²ΡΠΊΠ°Ρ 3 ΠΡΡΠ»ΠΎΠ²ΡΠΊΠΎΠΉ ΡΡΡΡΠΊΡΡΡΡ (Π’ΠΎΠΌΡΠΊΠ°Ρ ΠΎΠ±Π»Π°ΡΡΡ). Π‘Π°ΠΌΠΎΡΡΠΎΡΡΠ΅Π»ΡΠ½ΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠΎΡΠ²ΡΡΠ΅Π½ΠΎ ΠΏΠ°Π»Π΅ΠΎΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΠ½ΠΎΠΌΡ ΠΌΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ Π³Π΅Π½Π΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»Π° ΡΠΎΠ³ΡΡΡΠΊΠΎΠΉ Π½Π΅ΡΡΠ΅ΠΌΠ°ΡΠ΅ΡΠΈΠ½ΡΠΊΠΎΠΉ ΡΠ²ΠΈΡΡ Π² ΡΡΡΡΠΊΡΡΡΠ΅ ΠΠ°ΠΊΡΠ°ΡΡΠΊΠΎΠΉ Π²ΠΏΠ°Π΄ΠΈΠ½Ρ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΡΠ°Π±ΠΎΡ ΠΎΡΡΠ°ΠΆΠ΅Π½Ρ Π² 8 ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΡΡ
.Based on the analysis of previously performed geoscience, a project was carried out to conduct a complex of well logging in an open hole of well Krylovskaya 3 of Krylov structure (Tomsk region). The independent research is devoted to paleotemperature modeling and the determination of the generation potential of the togura oil source suite in the structures of the Bakchar depression. The results of the work are reflected in 8 publications
Π’Π΅Ρ Π½ΠΎΠ»ΠΎΠ³ΠΈΡ ΡΡΡ ΠΎΠ³ΠΎ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²Π° ΡΠΎΡΡΠΎΡΠΈΡΠΎΠ²ΠΎΠΉ ΠΌΡΠΊΠΈ
ΠΠΏΠΈΡΠ°Π½Π° ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΡΡ Π²ΠΈΡΠΎΠ±Π½ΠΈΡΡΠ²Π° ΡΡΡ
ΠΎΠ³ΠΎ ΡΠΎΡΡΠΎΡΠΈΡΠΎΠ²ΠΎΠ³ΠΎ Π±ΠΎΡΠΎΡΠ½Π°, ΡΠΊΠ° Π²ΠΊΠ»ΡΡΠ°Ρ ΠΏΡΠΎΡΡΠ²Π°Π½Π½Ρ, Π΄ΡΡΠ±Π½Π΅ Π΄ΡΠΎΠ±Π»Π΅Π½Π½Ρ, ΡΠ΅ΡΠΌΡΡΠ½Ρ ΡΡΡΡΠ½Π½Ρ, ΠΊΡΠ»ΡΠΎΠ²Π΅ ΠΏΠΎΠ΄ΡΡΠ±Π½Π΅Π½Π½Ρ Π² Π·Π°ΠΌΠΊΠ½ΡΡΠΎΠΌΡ ΡΠΈΠΊΠ»Ρ Π· ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΠΈΠΌ ΡΠ΅ΠΏΠ°ΡΠ°ΡΡΡΡ, ΠΏΠ½Π΅Π²ΠΌΠΎΡΡΠ°Π½ΡΠΏΠΎΡΡ ΡΠΎΡΡΠΎΡΠΈΡΠΎΠ²ΠΎΠ³ΠΎ Π±ΠΎΡΠΎΡΠ½Π° Π² ΡΠΈΠ»ΠΎΡΡ. ΠΡΠΎΠ΄ΡΠΊΡΠΈΠ²-Π½ΡΡΡΡ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΎΡ Π»ΡΠ½ΡΡ β 150 ΡΠΈΡ. Ρ Ρ ΡΡΠΊ. ΠΡΡΠΏΠ½ΠΎΡΡΡ ΠΏΠΎΠΌΠΎΠ»Ρ ΡΡΠ°Π½ΠΎΠ²ΠΈΡΡ 70% ΠΊΠ». 0,16 ΠΌΠΌ ΠΏΡΠΈ Π²ΠΎΠ»ΠΎΠ³ΠΎΡΡΡ 1%.ΠΠΏΠΈΡΠ°Π½Π° ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΡ ΡΡΡ
ΠΎΠ³ΠΎ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²Π° ΡΠΎΡΡΠΎΡΠΈΡΠΎΠ²ΠΎΠΉ ΠΌΡΠΊΠΈ, ΠΊΠΎΡΠΎΡΠ°Ρ Π²ΠΊΠ»ΡΡΠ°Π΅Ρ Π³ΡΠΎΡ
ΠΎΡΠ΅Π½ΠΈΠ΅, ΠΌΠ΅Π»ΠΊΠΎΠ΅ Π΄ΡΠΎΠ±Π»Π΅Π½ΠΈΠ΅, ΡΠ΅ΡΠΌΠΈΡΠ΅ΡΠΊΡΡ ΡΡΡΠΊΡ, ΡΠ°ΡΠΎΠ²ΠΎΠ΅ ΠΈΠ·ΠΌΠ΅Π»ΡΡΠ΅Π½ΠΈΠ΅ Π² Π·Π°ΠΌΠΊΠ½ΡΡΠΎΠΌ ΡΠΈΠΊΠ»Π΅ Ρ ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΡΠΌ Π³ΡΠΎΡ
ΠΎΡΠ΅Π½ΠΈΠ΅ΠΌ, ΠΏΠ½Π΅Π²ΠΌΠΎΡΡΠ°Π½ΡΠΏΠΎΡΡ ΡΠΎΡΡΠΎΡΠΈΡΠΎΠ²ΠΎΠΉ ΠΌΡΠΊΠΈ Π² ΡΠΈΠ»ΠΎΡΠ°. ΠΡΠΎΠΈΠ·Π²ΠΎΠ΄ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π»ΠΈΠ½ΠΈΠΈ β 150 ΡΡΡ. Ρ Π² Π³ΠΎΠ΄. ΠΡΡΠΏΠ½ΠΎΡΡΡ ΠΏΠΎΠΌΠΎΠ»Π° ΡΠΎΡΡΠ°Π²Π»ΡΠ΅Ρ 70% ΠΊΠ». 0,16 ΠΌΠΌ ΠΏΡΠΈ Π²Π»Π°ΠΆΠ½ΠΎΡΡΠΈ 1%
ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π²Π»ΠΈΡΠ½ΠΈΡ Π΄Π°Π²Π»Π΅Π½ΠΈΡ ΠΈ ΡΠ°ΡΡ ΠΎΠ΄Π° ΡΡΡΡΡ Π½Π° Ρ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠΈ ΠΏΡΠΎΠ΄ΡΠΊΡΠΎΠ² ΡΠ΅ΠΎΡΠΎΡΠΌΠΈΠ½Π³Π° Π³Π°Π·ΠΎΠ²ΠΎΠ³ΠΎ ΠΊΠΎΠ½Π΄Π΅Π½ΡΠ°ΡΠ° ΡΡΠ°Π±ΠΈΠ»ΡΠ½ΠΎΠ³ΠΎ
Π‘ΠΈΠ½ΡΠ΅Π· Π½ΠΈΠ·ΠΊΠΎΠ·Π°ΡΡΡΠ²Π°ΡΡΠΈΡ ΠΌΠ°ΡΠ΅Π» Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΎΠ»ΠΈΠ³ΠΎΠΌΠ΅ΡΠΎΠ² Π΄Π΅ΡΠ΅Π½Π° Π½Π° ΠΌΠΈΠΊΡΠΎ- ΠΈ ΠΌΠΈΠΊΡΠΎ-ΠΌΠ΅Π·ΠΎΠΏΠΎΡΠΈΡΡΡΡ ΡΠ΅ΠΎΠ»ΠΈΡΠ°Ρ Y
ΠΠΊΡΡΠ°Π»ΡΠ½ΠΎΡΡΡ Π±ΡΡΠΎΠ²Π·ΡΡΠ²Π½ΡΡ ΡΠ°Π±ΠΎΡ Ρ ΠΏΡΡΠΌΡΠΌΠΈ Π²ΡΡΠ±Π°ΠΌΠΈ ΠΏΡΠΈ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠΈ Π³ΠΎΡΠΈΠ·ΠΎΠ½ΡΠ°Π»ΡΠ½ΡΡ Π³ΠΎΡΠ½ΠΎ-ΡΠ°Π·Π²Π΅Π΄ΠΎΡΠ½ΡΡ Π²ΡΡΠ°Π±ΠΎΡΠΎΠΊ
Π‘ΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΠ΅ ΡΠ΅Π½Π΄Π΅Π½ΡΠΈΠΈ Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΡΡΡΠ°Ρ ΠΎΠ²ΡΡ ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΉ Π Π€ ΠΏΠΎ Π°Π²ΡΠΎΡΡΡΠ°Ρ ΠΎΠ²Π°Π½ΠΈΡ (Π½Π° ΠΏΡΠΈΠΌΠ΅ΡΠ΅ ΠΠΠ Π‘Π Β«ΠΠΎΠΌΠ΅ΡΡΡΠ°-Π‘ΡΡΠ°Ρ ΠΎΠ²Π°Π½ΠΈΠ΅Β»)
ΠΠ±ΡΠ΅ΠΊΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π² Π΄Π°Π½Π½ΠΎΠΉ ΡΠ°Π±ΠΎΡΠ΅ ΡΡΠ½ΠΎΠΊ Π°Π²ΡΠΎΡΡΡΠ°Ρ
ΠΎΠ²Π°Π½ΠΈΡ Π ΠΎΡΡΠΈΠΈ. Π¦Π΅Π»ΡΡ ΡΠ°Π±ΠΎΡΡ Π±ΡΠ»ΠΎ: ΠΈΠ·ΡΡΠΈΡΡ ΡΡΠ½ΠΎΠΊ Π°Π²ΡΠΎΡΡΡΠ°Ρ
ΠΎΠ²Π°Π½ΠΈΡ Π ΠΎΡΡΠΈΠΈ Π½Π° ΠΏΡΠΈΠΌΠ΅ΡΠ΅ ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΈ "ΠΠΎΠΌΠ΅ΡΡΡΠ° ΡΡΡΠ°Ρ
ΠΎΠ²Π°Π½ΠΈΠ΅".ΠΡΠ½ΠΎΠ²Π½ΡΠΌΠΈ Π·Π°Π΄Π°ΡΠ°ΠΌΠΈ Π±ΡΠ»ΠΎ:ΠΈΠ·ΡΡΠΈΡΡ ΡΡΡΠ½ΠΎΡΡΡ ΠΈ ΡΡΡΡΠΊΡΡΡΡ ΡΡΡΠ°Ρ
ΠΎΠ²ΠΎΠ³ΠΎ ΡΡΠ½ΠΊΠ°,Π΄Π°ΡΡ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΡ ΡΡΠ°ΡΡΠ½ΠΈΠΊΠΎΠ² ΡΡΡΠ°Ρ
ΠΎΠ²ΠΎΠ³ΠΎ ΡΡΠ½ΠΊΠ°,ΠΏΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°ΡΡ ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ ΡΠΎΡΡΠΈΠΉΡΠΊΠΎΠ³ΠΎ ΡΡΡΠ°Ρ
ΠΎΠ²ΠΎΠ³ΠΎ ΡΡΠ½ΠΊΠ° Π² ΡΠ°ΡΡΠΈ Π΅Π³ΠΎ Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠΈ, ΠΌΠ°ΡΡΡΠ°Π±ΠΎΠ², ΡΡΠΎΠ²Π½Ρ ΠΎΠΊΠ°Π·ΡΠ²Π°Π΅ΠΌΡΡ
ΡΡΡΠ°Ρ
ΠΎΠ²ΡΡ
ΡΡΠ»ΡΠ³. ΠΠ°Π½Π½Π°Ρ ΡΠ΅ΠΌΠ° Π°ΠΊΡΡΠ°Π»ΡΠ½Π°, ΡΠ°ΠΊ ΠΊΠ°ΠΊ ΠΌΠ½ΠΎΠΆΠ΅ΡΡΠ²ΠΎ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΉ ΠΎΡΠΊΡΡΠ²Π°ΡΡΡΡ ΠΈ ΡΡΠ°ΡΠ°ΡΡΡΡ ΠΊΠΎΠ½ΠΊΡΡΠΈΡΠΎΠ²Π°ΡΡ Ρ ΡΠΆΠ΅ ΡΡΡΠΎΡΠ²ΡΠΈΠΌΠΈΡΡ ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΡΠΌΠΈ. Π Π΄Π°Π½Π½ΠΎΠΉ ΡΠ°Π±ΠΎΡΠ΅ ΠΏΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½ ΡΡΠ΄ ΡΠ΅ΡΠ΅Π½ΠΈΠΉ ΠΊΠΎΡΠΎΡΡΠ΅ ΠΌΠΎΠ³ΡΡ ΡΠ²Π΅Π»ΠΈΡΠΈΡΡ ΡΡΠΎΠ²Π΅Π½Ρ ΠΊΠΎΠ½ΠΊΡΡΠ΅Π½ΡΠΎΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΠΈ ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΈ Π² ΡΠ΅Π»ΠΎΠΌ.The object of research in this work is the car insurance market of Russia. The aim of the work was: to study the Russian auto insurance market using the example of the company "Comestra Insurance". The main tasks were: to study the nature and structure of the insurance market, to characterize the participants of the insurance market, to analyze the state of the Russian insurance market in terms of its dynamics, scale, level of insurance services provided. This topic is relevant, as many different companies open up and try to compete with already established companies. In this work, a number of solutions are proposed that can increase the level of competitiveness of the company as a whole
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