Integrated Fabry-Perot cavities as a mechanism for enhancing micro-ring resonator performance

We propose and experimentally demonstrate the enhancement in the filtering quality (Q) factor of an integrated micro-ring resonator (MRR) by embedding it in an integrated Fabry-Perot (FP) cavity formed by cascaded Sagnac loop reflectors (SLRs). By utilizing coherent interference within the FP cavity to reshape the transmission spectrum of the MRR, both the Q factor and the extinction ratio (ER) can be significantly improved. The device is theoretically analyzed, and practically fabricated on a silicon-on-insulator (SOI) wafer. Experimental results show that up to 11-times improvement in Q factor, together with an 8-dB increase in ER, can be achieved via our proposed method. The impact of varying structural parameters on the device performance is also investigated and verified by the measured spectra of the fabricated devices with different structural parameters.Comment: 9 pages, 6 figures, 33 Reference

A GPU-Accelerated Moving-Horizon Algorithm for Training Deep Classification Trees on Large Datasets

Decision trees are essential yet NP-complete to train, prompting the widespread use of heuristic methods such as CART, which suffers from sub-optimal performance due to its greedy nature. Recently, breakthroughs in finding optimal decision trees have emerged; however, these methods still face significant computational costs and struggle with continuous features in large-scale datasets and deep trees. To address these limitations, we introduce a moving-horizon differential evolution algorithm for classification trees with continuous features (MH-DEOCT). Our approach consists of a discrete tree decoding method that eliminates duplicated searches between adjacent samples, a GPU-accelerated implementation that significantly reduces running time, and a moving-horizon strategy that iteratively trains shallow subtrees at each node to balance the vision and optimizer capability. Comprehensive studies on 68 UCI datasets demonstrate that our approach outperforms the heuristic method CART on training and testing accuracy by an average of 3.44% and 1.71%, respectively. Moreover, these numerical studies empirically demonstrate that MH-DEOCT achieves near-optimal performance (only 0.38% and 0.06% worse than the global optimal method on training and testing, respectively), while it offers remarkable scalability for deep trees (e.g., depth=8) and large-scale datasets (e.g., ten million samples).Comment: 36 pages (13 pages for the main body, 23 pages for the appendix), 7 figure

Effects of galactooligosaccharides on maternal gut microbiota, glucose metabolism, lipid metabolism and inflammation in pregnancy: A randomized controlled pilot study

BackgroundGut microbiota of pregnant women change with the gestational week. On the one hand, they participate in the metabolic adaptation of pregnant women. On the other hand, the abnormal composition of gut microbiota of pregnant women is more likely to suffer from gestational diabetes mellitus (GDM). Therefore, gut microbiota targeted treatment through dietary supplements is particularly important for prevention or treatment. Prebiotic supplements containing galactooligosaccharides (GOS) may be an intervention method, but the effect is still unclear.ObjectiveThis study aims to evaluate the feasibility and acceptability of prebiotic intervention in healthy pregnant women during pregnancy, and to explore the possible effects of intervention on pregnant women and the influence on gut microbiota as preliminaries.MethodsAfter recruitment in first trimester, 52 pregnant women were randomly assigned to receive GOS intervention or placebo containing fructooligosaccharides. 16S rRNA sequencing technology was used to detect the composition, diversity and differential flora of gut microbiota. Lipid metabolism, glucose metabolism and inflammatory factors during pregnancy were also analyzed.ResultsThe adverse symptoms of GOS intervention are mild and relatively safe. For pregnant women, there was no significant difference in the GDM incidence rates and gestational weight gain (GWG) in the GOS group compared with placebo (P > 0.05). Compared with the placebo group, the levels of FPG, TG, TC, HDL-C LDL-C, and IL-6 had no significant difference in GOS group (P > 0.05). For newborns, there was no significant difference between GOS group and placebo group in the following variables including gestational week, birth weight, birth length, head circumference, chest circumference, sex, and delivery mode (P > 0.05). And compared with the placebo group, the GOS group had a higher abundance of Paraprevotella and Dorea, but lower abundance of LachnospiraceaeUCG_001.ConclusionsGOS prebiotics appear to be safe and acceptable for the enrolled pregnancies. Although GOS intervention did not show the robust benefits on glucose and lipid metabolism. However, the intervention had a certain impact on the compostion of gut microbiota. GOS can be considered as a dietary supplement during pregnancy, and further clinical studies are needed to explore this in the future

Maximizing the performance for microcomb based microwave photonic transversal signal processors

Microwave photonic (MWP) transversal signal processors offer a compelling solution for realizing versatile high-speed information processing by combining the advantages of reconfigurable electrical digital signal processing and high-bandwidth photonic processing. With the capability of generating a number of discrete wavelengths from micro-scale resonators, optical microcombs are powerful multi-wavelength sources for implementing MWP transversal signal processors with significantly reduced size, power consumption, and complexity. By using microcomb-based MWP transversal signal processors, a diverse range of signal processing functions have been demonstrated recently. In this paper, we provide a detailed analysis for the processing inaccuracy that is induced by the imperfect response of experimental components. First, we investigate the errors arising from different sources including imperfections in the microcombs, the chirp of electro-optic modulators, chromatic dispersion of the dispersive module, shaping errors of the optical spectral shapers, and noise of the photodetector. Next, we provide a global picture quantifying the impact of different error sources on the overall system performance. Finally, we introduce feedback control to compensate the errors caused by experimental imperfections and achieve significantly improved accuracy. These results provide a guide for optimizing the accuracy of microcomb-based MWP transversal signal processors.Comment: 15 pages, 12 figures, 60 reference

Molecular prevalence and subtype distribution of Blastocystis spp. among children who have diarrheia or are asymptomatic in Wenzhou, Zhejiang Province, China

Blastocystis sp., a significant zoonotic parasite with a global distribution, was the focus of this study, which aimed to investigate its prevalence and genetic diversity among diarrheic and asymptomatic children in Wenzhou, China. We collected 1,032 fecal samples from Yuying Children’s Hospital, Wenzhou, China, comprising 684 from children with diarrhea and 348 from asymptomatic children. Genomic DNA extracted from these samples was used to detect Blastocystis spp. by PCR, targeting the small subunit ribosomal RNA gene. Subsequently, a phylogenetic tree was constructed, applying the maximum likelihood method. Blastocystis spp. were detected in 67 (6.5%) of the fecal samples. The prevalence rate of Blastocystis spp. in diarrheic children (8.8%; 60/684) was significantly higher than that in asymptomatic children (2.0%; 7/348) (χ 2 = 17.3, p < 0.001). Sequence analysis of the SSU rRNA gene identified five known Blastocystis spp. subtypes, ST1 (n = 12), ST2 (n = 5), ST3 (n = 35), ST4 (n = 12), and ST7 (n = 3). ST1 and ST3 were present in both diarrheic and asymptomatic children, while ST2, ST4, and ST7 were exclusive to diarrheic children. Intra-subtype genetic polymorphisms were identified, comprising four variations in ST1 (ST1-1 to ST1-4), five in ST3 (ST3-1 to ST3-5), two in ST4 (ST4-1 and ST4-2), and two in ST7 (ST7-1 and ST7-2). Notably, ST1-2 to ST1-4, ST3-3 to ST3-5, and ST7-1 and ST7-2 represent newly identified variations. The composition and genetic characteristics of subtypes among children in this region suggest various sources of infection, including human-to-human and animal-to-human transmission

Phytophthora infestans RXLR effectors act in concert at diverse subcellular locations to enhance host colonization

Oomycetes such as the potato blight pathogen Phytophthora infestans deliver RXLR effectors into plant cells to manipulate host processes and promote disease. Knowledge of where they localize inside host cells is important in understanding their function. Fifty-two P. infestans RXLR effectors (PiRXLRs) up-regulated during early stages of infection were expressed as fluorescent protein (FP) fusions inside cells of the model host Nicotiana benthamiana. FP-PiRXLR fusions were predominantly nucleo-cytoplasmic, nuclear, or plasma membrane-associated. Some also localized to the endoplasmic reticulum, mitochondria, peroxisomes, or microtubules, suggesting diverse sites of subcellular activity. Seven of the 25 PiRXLRs examined during infection accumulated at sites of haustorium penetration, probably due to co-localization with host target processes; Pi16663 (Avr1), for example, localized to Sec5-associated mobile bodies which showed perihaustorial accumulation. Forty-five FP-RXLR fusions enhanced pathogen leaf colonization when expressed in Nicotiana benthamiana, revealing that their presence was beneficial to infection. Co-expression of PiRXLRs that target and suppress different immune pathways resulted in an additive enhancement of colonization, indicating the potential to study effector combinations using transient expression assays. We provide a broad platform of high confidence P. infestans effector candidates from which to investigate the mechanisms, singly and in combination, by which this pathogen causes disease.</p

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Effect of WC particles preparation method on microstructure and properties of laser cladded Ni60-WC coatings

Ni60 and WC composite coatings were prepared on 17-4PH martensitic stainless steel with 30 wt% agglomeration-sintering WC (AS-WC) or 30 wt% sintering-crushing WC (SC-WC) respectively. The results show that in the AS-WC doped coating, the WC particles are more easily melted and dispersed, and a large amount of acicular (Fe, Ni, W)23C6 carbides are dispersed throughout the coating. However, in the SC-WC doped coating, the melting is quite limited and only occurs at the outer edge of the WC particles, and a small amount of (Fe, Ni, W)23C6 precipitated in the coating. Owing to this microstructure difference, the AS-WC doped coating possesses higher hardness, the microhardness reached 622.27 HV0.2 which is 25.5% higher than the normal Ni60 coating without WC, and 10.0% higher than the SC-WC doped coating. Moreover, the wear resistance test results indicate that the AS-WC doped coating has the best wear resistance compared to the SC-WC doped coating and normal Ni60 coating without WC. Those findings help us to obtain better Ni-based high hardness coatings for industrial applications

Impact of solid particles on cavitation behaviors and laser-induced degradation in aqueous suspension

A method for degrading organic pollutants in suspension by applying laser-induced cavitation is presented. Cavitation bubbles are produced remotely by laser beams, achieving a purpose of non-contact degradation. In this work, laser-induced bubble dynamics in SiO2 sand suspension were studied by high-speed imaging. Pulsating characteristics of cavitaiton bubbles in the infinite domain and near a solid boundary were investigated among various laser energies and sand concentrations. Furthermore, the extent of degradation after processing in suspension and the mechanism were analyzed. Results indicate that solid particles in the liquid medium reduce the extent of degradation. However, the extent of degradation may rebound at a proper sand concentration. In addition, compared to several small bubbles in a bubble string (in the infinite domain), a single larger bubble (near a solid boundary) has a much higher degradation ability

Impact of Time-Restricted Feeding on Adaptation to a 6-Hour Delay Phase Shift or a 12-Hour Phase Shift in Mice

Nowadays, more and more people are suffering from circadian disruption. However, there is no well-accepted treatment. Recently, time-restricted feeding (TRF) was proposed as a potential non-drug intervention to alleviate jet lag in mice, especially in mice treated with a 6-h advanced phase shift. Here, we challenged C57BL/6 mice with a 6-h delay phase shift or a 12-h shift (day-night reversal) combined with 6- or 12-h TRF within the dark phase and found the beneficial effects of given TRF strategies in certain phase-shifting situations. Although behavioral fitness did not correlate well with health status, none of the TRF strategies we used deteriorated lipopolysaccharide-induced sepsis. These findings improve our understanding of the benefits of TRF for adaptation to circadian disruption