Salvage cytoreductive surgery for patients with recurrent endometrial cancer: a retrospective study

BACKGROUND: Salvage cytoreductive surgery (SCR) has been shown to improve the survival of cancer patients. This study aimed to determine the survival benefits of SCR for recurrent endometrial cancer in Chinese population. METHODS: Between January 1995 and May 2012, 75 Chinese patients with recurrent endometrial cancer undergoing SCR were retrospectively analyzed. RESULTS: 43 patients (57.3%) had R0 (no visible disease), 15 patients (20.0%) had R1 (residual disease ≤1 cm), and 17 (22.7%) had R2 (residual disease >1 cm) Resection. 35 patients (46.7%) had single, and 40 (53.3%) had multiple sites of recurrence. The median survival time was 18 months, and 5-year overall survival (OS) rate were 42.0%. Multivariate analysis showed that residual disease ≤1 cm and high histology grade were significantly associated with a better OS. The size of the largest recurrent tumors (≤6 cm), solitary recurrent tumor, and age at recurrence (≤56 years old) were associated with optimal SCR. CONCLUSION: Optimal SCR and high histology grade are associated with prolonged overall survival for patients with recurrent endometrial cancer. Patients with young age, tumor size < 6 cm, and solitary recurrent tumor are more likely to benefit from optimal cytoreductive surgery

Precision Control of Amphoteric Doping in Cu x Bi2Se3 Nanoplates.

Copper-doped Bi2Se3 (Cu x Bi2Se3) is of considerable interest for tailoring its electronic properties and inducing exotic charge correlations while retaining the unique Dirac surface states. However, the copper dopants in Cu x Bi2Se3 display complex electronic behaviors and may function as either electron donors or acceptors depending on their concentration and atomic sites within the Bi2Se3 crystal lattice. Thus, a precise understanding and control of the doping concentration and sites is of both fundamental and practical significance. Herein, we report a solution-based one-pot synthesis of Cu x Bi2Se3 nanoplates with systematically tunable Cu doping concentrations and doping sites. Our studies reveal a gradual evolution from intercalative sites to substitutional sites with increasing Cu concentrations. The Cu atoms at intercalative sites function as electron donors while those at the substitutional sites function as electron acceptors, producing distinct effects on the electronic properties of the resulting materials. We further show that Cu0.18Bi2Se3 exhibits superconducting behavior, which is not present in Bi2Se3, highlighting the essential role of Cu doping in tailoring exotic quantum properties. This study establishes an efficient methodology for precise synthesis of Cu x Bi2Se3 with tailored doping concentrations, doping sites, and electronic properties

The relevance study of effective information between near infrared spectroscopy and chondroitin sulfate in ethanol precipitation process

Near infrared spectroscopy (NIRS) is based on molecular overtone and combination vibrations. It is difficult to assign specific features under complicated system. So it is necessary to find the relevance between NIRS and target compound. For this purpose, the chondroitin sulfate (CS) ethanol precipitation process was selected as the research model, and 90 samples of 5 different batches were collected and the content of CS was determined by modified carbazole method. The relevance between NIRS and CS was studied throughout optical pathlength, pretreatment methods and variables selection methods. In conclusion, the first derivative with Savitzky–Golay (SG) smoothing was selected as the best pretreatment, and the best spectral region was selected using interval partial least squares (iPLS) method under 1 mm optical cell. A multivariate calibration model was established using PLS algorithm for determining the content of CS, and the root mean square error of prediction (RMSEP) is 3.934 g⋅L-1. This method will have great potential in process analytical technology in the future

Broadband nonlinear modulation of incoherent light using a transparent optoelectronic neuron array

Nonlinear optical processing of ambient natural light is highly desired in computational imaging and sensing applications. A strong optical nonlinear response that can work under weak broadband incoherent light is essential for this purpose. Here we introduce an optoelectronic nonlinear filter array that can address this emerging need. By merging 2D transparent phototransistors (TPTs) with liquid crystal (LC) modulators, we create an optoelectronic neuron array that allows self-amplitude modulation of spatially incoherent light, achieving a large nonlinear contrast over a broad spectrum at orders-of-magnitude lower intensity than what is achievable in most optical nonlinear materials. For a proof-of-concept demonstration, we fabricated a 10,000-pixel array of optoelectronic neurons, each serving as a nonlinear filter, and experimentally demonstrated an intelligent imaging system that uses the nonlinear response to instantly reduce input glares while retaining the weaker-intensity objects within the field of view of a cellphone camera. This intelligent glare-reduction capability is important for various imaging applications, including autonomous driving, machine vision, and security cameras. Beyond imaging and sensing, this optoelectronic neuron array, with its rapid nonlinear modulation for processing incoherent broadband light, might also find applications in optical computing, where nonlinear activation functions that can work under ambient light conditions are highly sought.Comment: 20 Pages, 5 Figure

Cross-Modal Image Retrieval Considering Semantic Relationships With Many-to-Many Correspondence Loss

A cross-modal image retrieval that explicitly considers semantic relationships between images and texts is proposed. Most conventional cross-modal image retrieval methods retrieve the target images by directly measuring the similarities between the candidate images and query texts in a common semantic embedding space. However, such methods tend to focus on a one-to-one correspondence between a predefined image-text pair during the training phase, and other semantically similar images and texts are ignored. By considering the many-to-many correspondences between semantically similar images and texts, a common embedding space is constructed to assure semantic relationships, which allows users to accurately find more images that are related to the input query texts. Thus, in this paper, we propose a cross-modal image retrieval method that considers semantic relationships between images and texts. The proposed method calculates the similarities between texts as semantic similarities to acquire the relationships. Then, we introduce a loss function that explicitly constructs the many-to-many correspondences between semantically similar images and texts from their semantic relationships. We also propose an evaluation metric to assess whether each method can construct an embedding space considering the semantic relationships. Experimental results demonstrate that the proposed method outperforms conventional methods in terms of this newly proposed metric

Guillain-Barré syndrome and Low back pain: two cases and literature review

Purpose. To describe the clinical, electrophysiological, and lumbar magnetic resonance imaging (MRI) features of two cases of atypical Guillain-Barré syndrome (GBS). Methods We reported two GBS variant cases with initial and prominent symptoms of low back pain. We analysed their clinical, electrophysiological, and lumbar MRI features. Results Two patients with GBS reported low back pain as the initial and prominent symptom, which was not accompanied by limb weakness. The electrophysiological study showed abnormal F-waves in the common peroneal and tibial nerves, and acute polyradiculoneuropathy in the cauda equina. Examination of the cerebrospinal fluid (CSF) showed albuminocytologic dissociation. Serum was positive for GQ1b-IgM antibodies. Lumbar MRI showed gadolinium enhancement of the nerve roots and cauda equina. A standard regime of intravenous immunoglobulin markedly alleviated the low back pain. Conclusions Low back pain caused by GBS should be differentiated from other diseases. This initial or early prominent symptom may delay the diagnosis of GBS; therefore, it is important to conduct a detailed electrophysiological, CSF, and gadolinium-enhanced lumbar MRI analysis

Geochemical characteristics and oxidation states of the Xietongmen ore-bearing porphyries: Implication for the genetic types of the Xietongmen No. I and No. II deposits, southern Tibet

The Xietongmen large deposit is the only known subduction-related porphyry Cu deposit in the Gangdese Belt, Tibet, which is composed of the No. I and No. II deposits. Previous work suggests that the No. I deposit is reduced while the No. II deposit is oxidized. However, it is ambiguous that both oxidized and reduced porphyry Cu deposits occur in close proximity, in the same tectonic setting, and within a short time period. Detailed examination of the ages, whole-rock geochemistry, zircon and apatite compositions of the Xietongmen No. I and No. II ore-bearing porphyries are conducted to investigate their magma characteristics and the genetic types of the Xietongmen No. I and No. II deposits. Zircon U-Pb dating results show that the Xietongmen No. I and No. II ore-bearing porphyries formed at 166.3 +/- 2.6 Ma and 175.5 +/- 1.0 Ma, respectively. The Xietongmen No. I and No. II ore-bearing porphyries have similar mineral assemblage (containing amphibole phenocryst), high Sr/Y ratios and negligible negative Eu anomalies, low Ti-in-zircon temperatures (633-749 and 633-763 degrees C, respectively), which indicate that their magmas are water-rich. In addition, the Xietongmen No. I and No. II ore-bearing porphyries have: (a) high whole-rock V/Sc ratios (10-15 and 8-16, respectively); (b) high zircon Ce4+/Ce3+ and Eu-N/Eu-N* ratios, falling into the field of the ore-bearing intrusions in northern Chile; (c) low apatite Ce-N/Ce-N* ratios (0.97-1.02 and 0.99-1.02, respectively), which suggest that their magmas are oxidized. The estimated magmatic S contents, based on the magmatic apatite SO3 contents, yield 0.0113-0.0507 wt% and 0.0012-0.0118 wt%, respectively for the Xietongmen No. I and No. II ore-bearing porphyries, which suggest their magma are sulfur-rich. Hydrous, oxidized and sulfur-rich magmas are the parent magma of oxidized porphyry Cu deposits, together with the oxidized minerals of hematite and magnetite, therefore, both Xietongmen No. I and No. II deposit are oxidized porphyry Cu deposits, rather than that the Xietongmen No. I deposit is a reduced porphyry Cu deposit

The petrogenesis of early Paleozoic high-Ba-Sr intrusions in the North Qinling terrane, China, and tectonic implications

High-Ba-Sr (HiBaSr) intrusions provide important insights into early Paleozoic magmatism and tectonic evolution of the Qinling orogenic belt, China. Here, new zircon U-Pb ages, whole-rock major and trace element data, and Sr-Nd-Hf isotopic compositions are presented for three HiBaSr dioritic intrusions (Yangjiazhuang and Tangzang quartz diorite intrusions and Honghuapu diorite intrusion) in the North Qinling terrane. The Yangjiazhuang quartz diorites and Honghuapu diorites are high-K calc-alkalic to shoshonitic rocks, whereas the Tangzang quartz diorites are Na-rich calc-alkalic rocks. LA-ICP-MS zircon U-Pb dating indicates that the K rich dioritic intrusions were formed at 439-438 Ma, and the Na-rich intrusion at 429-425 Ma. Rocks of the three intrusions are metaluminous to weakly peraluminous, and are characterized by high Ba and Sr contents of 792-3050 and 579-1385 ppm, respectively, with obvious enrichment in LILE5 (e.g., Rb, Ba, Th, and U) and depletion in HFSEs (e.g., Nb, Ta, and Ti). They exhibit relatively uniform Sr and Nd isotopic compositions with (Sr-87/Sr-86); ratios of 0.7032-0.7059, epsilon(Nd)(t) values of -0.65 to -2.78, and two-stage Nd model ages (T-DM2) of 1.23-1.39 Ga, indicative of an enriched mantle source. The K-rich intrusions exhibit minor Nd-Hf isotopic decoupling (Delta epsilon(Hf)(t) = 2.93-5.01) and have low Nb/U ratios (2.11-3.01) and Mg numbers (48.5-52.1), suggesting that the Yangjiazhuang quartz diorites and Honghuapu diorites were formed through fractional crystallization of partial melts of enriched mantle metasomatized by terrigenous-sediment-derived fluids. The Na-rich Tangzang quartz diorites exhibit distinct Delta epsilon(Hf)(t) values (5.72-9.35) and elemental contents (e.g., high Na2O and Nb), and highly variable Rb/Y, Nb/Y, Th/Zr, and Nb/Zr ratios, indicating that they formed through crustal assimilation and fractional crystallization of partial melts of enriched mantle previously fertilized by terrigenous sediment-derived fluids and slab melts. Petrogenetic models for the HiBaSr dioritic rocks and Late Ordovician-Silurian igneous rocks of the western North Qinling terrane indicate that the K-rich HiBaSr intrusions formed in a slab subduction setting, whereas the Na-rich intrusion was controlled by slab break-off after continental collision. Together with granulite-facies metamorphism in the region, the emplacement of the HiBaSr dioritic rocks indicates that the closure of the Shangdan Ocean and initial collision between the North China Craton and Yangtze Block occurred at ca 433 Ma, with subsequent slab break-off triggering extensive Silurian magmatism at ca 430-402 Ma. (C) 2018 Elsevier B.V. All rights reserved