5 research outputs found
La tecnología que aprende a elegir tu talla de calzado
Ballester Fernandez, A.; Gil Mora, S.; Valero, J.; Gonzalez Garcia, JC.; Remon Gomez, A. (2019). La tecnología que aprende a elegir tu talla de calzado. Innovación biomecánica en Europa. (8):1-3. http://hdl.handle.net/10251/167979S13
Polyphenol intake and mortality risk: a re-analysis of the PREDIMED trial
Background: Polyphenols may lower the risk of cardiovascular disease (CVD) and other chronic diseases due to
their antioxidant and anti-inflammatory properties, as well as their beneficial effects on blood pressure, lipids and
insulin resistance. However, no previous epidemiological studies have evaluated the relationship between the intake
of total polyphenols intake and polyphenol subclasses with overall mortality. Our aim was to evaluate whether
polyphenol intake is associated with all-cause mortality in subjects at high cardiovascular risk.
Methods: We used data from the PREDIMED study, a 7,447-participant, parallel-group, randomized, multicenter,
controlled five-year feeding trial aimed at assessing the effects of the Mediterranean Diet in primary prevention of
cardiovascular disease. Polyphenol intake was calculated by matching food consumption data from repeated food
frequency questionnaires (FFQ) with the Phenol-Explorer database on the polyphenol content of each reported
food. Hazard ratios (HR) and 95% confidence intervals (CI) between polyphenol intake and mortality were estimated
using time-dependent Cox proportional hazard models.
Results: Over an average of 4.8 years of follow-up, we observed 327 deaths. After multivariate adjustment, we
found a 37% relative reduction in all-cause mortality comparing the highest versus the lowest quintiles of total
polyphenol intake (hazard ratio (HR) = 0.63; 95% CI 0.41 to 0.97; P for trend = 0.12). Among the polyphenol subclasses,
stilbenes and lignans were significantly associated with reduced all-cause mortality (HR =0.48; 95% CI 0.25 to 0.91; P for
trend = 0.04 and HR = 0.60; 95% CI 0.37 to 0.97; P for trend = 0.03, respectively), with no significant associations apparent
in the rest (flavonoids or phenolic acids).
Conclusions: Among high-risk subjects, those who reported a high polyphenol intake, especially of stilbenes and
lignans, showed a reduced risk of overall mortality compared to those with lower intakes. These results may be useful
to determine optimal polyphenol intake or specific food sources of polyphenols that may reduce the risk of all-cause
mortality.
Clinical trial registration: ISRCTN35739639
MOVE 4D: el IBV desarrolla el sistema más avanzado de escaneado del cuerpo humano en movimiento
[ES] El Instituto de Biomecánica (IBV) se sitúa en la vanguardia de la tecnología digital de caracterización antropométrica y biomecánica del cuerpo humano, mediante el desarrollo del equipo MOVE 4D, un sistema de escaneado corporal en movimiento de alta precisión y velocidad. Con este sistema se abren nuevas opciones de avance y desarrollo en sectores tan variados como la indumentaria-textil, la valoración biomecánica en salud y deporte, la animación digital o los vídeo-juegos.El trabajo actual se ha desarrollado en el marco del proyecto 3D-body-dynamics financiado por el IVACE dentro del programa de subvenciones dirigidas a los centros tecnológicos de Comunidad Valenciana para el desarrollo de proyectos de I+D no económicos. Está cofinanciado por el Fondo Europeo de Desarrollo Regional (FEDER) en un porcentaje del 50% a través del programa operativo FEDER de la Comunidad Valenciana 2014-2020. La colaboración con el IBV del investigador Dr. Alfredo Remón está cofinanciada por el programa Torres Quevedo (Ref. PTQ -16- 08205)Alemany Mut, MS.; Garrido Jaen, JD.; Parrilla Bernabé, E.; Mañas Ballester, B.; Remon Gomez, A. (2019). MOVE 4D: el IBV desarrolla el sistema más avanzado de escaneado del cuerpo humano en movimiento. Revista de Biomecánica (Online). (66):1-4. http://hdl.handle.net/10251/159754S146
3D-body-hub: Herramientas para incorporar la antropometría en el diseño de producto
Solves Camallonga, C.; Gil Mora, S.; Nacher Fernandez, B.; Uriel-Molto, J.; Ballester Fernandez, A.; Alemany Mut, MS.; Remon Gomez, A.... (2019). 3D-body-hub: Herramientas para incorporar la antropometría en el diseño de producto. Innovación biomecánica en Europa. (8):1-9. http://hdl.handle.net/10251/169346S19
Polyphenol intake and mortality risk: a re-analysis of the PREDIMED trial
Background: Polyphenols may lower the risk of cardiovascular disease (CVD) and other chronic diseases due to
their antioxidant and anti-inflammatory properties, as well as their beneficial effects on blood pressure, lipids and
insulin resistance. However, no previous epidemiological studies have evaluated the relationship between the intake
of total polyphenols intake and polyphenol subclasses with overall mortality. Our aim was to evaluate whether
polyphenol intake is associated with all-cause mortality in subjects at high cardiovascular risk.
Methods: We used data from the PREDIMED study, a 7,447-participant, parallel-group, randomized, multicenter,
controlled five-year feeding trial aimed at assessing the effects of the Mediterranean Diet in primary prevention of
cardiovascular disease. Polyphenol intake was calculated by matching food consumption data from repeated food
frequency questionnaires (FFQ) with the Phenol-Explorer database on the polyphenol content of each reported
food. Hazard ratios (HR) and 95% confidence intervals (CI) between polyphenol intake and mortality were estimated
using time-dependent Cox proportional hazard models.
Results: Over an average of 4.8 years of follow-up, we observed 327 deaths. After multivariate adjustment, we
found a 37% relative reduction in all-cause mortality comparing the highest versus the lowest quintiles of total
polyphenol intake (hazard ratio (HR) = 0.63; 95% CI 0.41 to 0.97; P for trend = 0.12). Among the polyphenol subclasses,
stilbenes and lignans were significantly associated with reduced all-cause mortality (HR =0.48; 95% CI 0.25 to 0.91; P for
trend = 0.04 and HR = 0.60; 95% CI 0.37 to 0.97; P for trend = 0.03, respectively), with no significant associations apparent
in the rest (flavonoids or phenolic acids).
Conclusions: Among high-risk subjects, those who reported a high polyphenol intake, especially of stilbenes and
lignans, showed a reduced risk of overall mortality compared to those with lower intakes. These results may be useful
to determine optimal polyphenol intake or specific food sources of polyphenols that may reduce the risk of all-cause
mortality.
Clinical trial registration: ISRCTN35739639