Active Control of Low-Speed Fan Tonal Noise Using Actuators Mounted in Stator Vanes: Part III Results

A test program to demonstrate simplification of Active Noise Control (ANC) systems relative to standard techniques was performed on the NASA Glenn Active Noise Control Fan from May through September 2001. The target mode was the m = 2 circumferential mode generated by the rotor-stator interaction at 2BPF. Seven radials (combined inlet and exhaust) were present at this condition. Several different error-sensing strategies were implemented. Integration of the error-sensors with passive treatment was investigated. These were: (i) an in-duct linear axial array, (ii) an induct steering array, (iii) a pylon-mounted array, and (iv) a near-field boom array. The effect of incorporating passive treatment was investigated as well as reducing the actuator count. These simplified systems were compared to a fully ANC specified system. Modal data acquired using the Rotating Rake are presented for a range of corrected fan rpm. Simplified control has been demonstrated to be possible but requires a well-known and dominant mode signature. The documented results here in are part III of a three-part series of reports with the same base title. Part I and II document the control system and error-sensing design and implementation

Methods for designing treatments to reduce interior noise of predominant sources and paths in a single engine light aircraft

The sources and paths by which noise enters the cabin of a small single engine aircraft were determined through a combination of flight and laboratory tests. The primary sources of noise were found to be airborne noise from the propeller and engine casing, airborne noise from the engine exhaust, structureborne noise from the engine/propeller combination and noise associated with air flow over the fuselage. For the propeller, the primary airborne paths were through the firewall, windshield and roof. For the engine, the most important airborne path was through the firewall. Exhaust noise was found to enter the cabin primarily through the panels in the vicinity of the exhaust outlet although exhaust noise entering the cabin through the firewall is a distinct possibility. A number of noise control techniques were tried, including firewall stiffening to reduce engine and propeller airborne noise, to stage isolators and engine mounting spider stiffening to reduce structure-borne noise, and wheel well covers to reduce air flow noise

A review of astrophysics experiments on intense lasers

Astrophysics has traditionally been pursued at astronomical observatories and on theorists’ computers. Observations record images from space, and theoretical models are developed to explain the observations. A component often missing has been the ability to test theories and models in an experimental setting where the initial and final states are well characterized. Intense lasers are now being used to recreate aspects of astrophysical phenomena in the laboratory, allowing the creation of experimental testbeds where theory and modeling can be quantitatively tested against data. We describe here several areas of astrophysics—supernovae, supernova remnants, gamma-ray bursts, and giant planets—where laser experiments are under development to test our understanding of these phenomena. © 2000 American Institute of Physics.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/71013/2/PHPAEN-7-5-1641-1.pd

Updated full range of Eliciting Dose values for Cow’s milk for use in food allergen risk assessment

Access to Eliciting Doses (ED) for allergens enables advanced food allergen risk assessment. Previously, the full ED range for 14 allergenic foods, including milk, and recommendations for their use were provided (Houben et al., 2020). Additional food challenge studies with cow’s milk-allergic patients added 247 data points to the original dataset. Using the Stacked Model Averaging statistical method for interval-censored data on the 697 individual NOAELs and LOAELs for milk generated an updated full ED distribution. The ED01 and ED05, the doses at which 1% and 5% of the milk-allergic population would be predicted to experience any objective allergic reaction, were 0.3 and 3.2 mg milk protein for the discrete and 0.4 mg and 4.3 mg milk protein for the cumulative dose distribution, respectively. These values are slightly higher but remain within the 95% confidence interval of previously published EDs. We recommend using the updated EDs for future characterization of risks of exposure of milk-allergic individuals to milk protein. This paper contributes to the discussion on the Reference Dose for milk in the recent Ad hoc Joint FAO/WHO Expert Consultation on Risk Assessment of Food Allergens. It will also benefit harmonization of food allergen risk assessment and risk management globally

An experimental testbed for the study of hydrodynamic issues in supernovae

More than a decade after the explosion of supernova 1987A, unresolved discrepancies still remain in attempts to numerically simulate the mixing processes initiated by the passage of a very strong shock through the layered structure of the progenitor star. Numerically computed velocities of the radioactive 56Ni56Ni and 56Co,56Co, produced by shock-induced explosive burning within the silicon layer, for example, are still more than 50% too low as compared with the measured velocities. To resolve such discrepancies between observation and simulation, an experimental testbed has been designed on the Omega Laser for the study of hydrodynamic issues of importance to supernovae (SNe). In this paper, results are presented from a series of scaled laboratory experiments designed to isolate and explore several issues in the hydrodynamics of supernova explosions. The results of the experiments are compared with numerical simulations and are generally found to be in reasonable agreement. © 2001 American Institute of Physics.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/69986/2/PHPAEN-8-5-2446-1.pd

Supernova hydrodynamics experiments on the Nova laser

In studying complex astrophysical phenomena such as supernovae, one does not have the luxury of setting up clean, well-controlled experiments in the universe to test the physics of current models and theories. Consequently, creating a surrogate environment to serve as an experimental astrophysics testbed would be highly beneficial. The existence of highly sophisticated, modern research lasers, developed largely as a result of the world-wide effort in inertial confinement fusion, opens a new potential for creating just such an experimental testbed utilizing well-controlled, well-diagnosed laser-produced plasmas. Two areas of physics critical to an understanding of supernovae are discussed that are amenable to supporting research on large lasers: (1) compressible nonlinear hydrodynamic mixing and (2) radiative shock hydrodynamics. © 1997 American Institute of Physics.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/69962/2/PHPAEN-4-5-1994-1.pd

Laser experiments to simulate supernova remnants

An experiment using a large laser facility to simulate young supernova remnants (SNRs) is discussed. By analogy to the SNR, the laboratory system includes dense matter that explodes, expansion and cooling to produce energetic, flowing plasma, and the production of shock waves in lower-density surrounding matter. The scaling to SNRs in general and to SN1987A in particular is reviewed. The methods and results of x-ray radiography, by which the system in diagnosed, are discussed. The data show that the hohlraum used to provide the energy for explosion does so in two ways—first, through its radiation pulse, and second, through an additional impulse that is attributed to stagnation pressure. Attempts to model these dynamics are discussed. © 2000 American Institute of Physics.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/69889/2/PHPAEN-7-5-2142-1.pd

A Nutritional Formulation for Cognitive Performance and Mood in Alzheimer’s Disease and Mild Cognitive Impairment: A Phase II Multi-site Randomized Trial with an Open-label Extension

Background: It is increasingly recognized that interventions for dementia must shift towards prevention to obtain maximal efficacy and any significant degree of disease modification. Nutritional supplementation with single agents has shown varied results, suggesting the need for combinatorial intervention. Methods: We conducted a 3-month, randomized, multi-site, phase II study in which 141 individuals diagnosed with Alzheimer’s disease (AD) and 34 individuals with Mild Cognitive Impairment received a nutraceutical formulation (NF; folate, alpha-tocopherol, B12, S-adenosyl methioinine, N-acetyl cysteine, acetyl-L-carnitine) or indistinguishable placebo under double-blind conditions, followed by an open-label extension in which all individuals received NF for a total of 1yr. An additional 38 individuals with AD received NF under open-label conditions from baseline for 1yr. The primary outcome was defined as cognitive performance. Secondary outcomes were defined as behavioral and psychological symptoms of dementia and activities of daily living. Results: Participants randomized to NF improved statistically within 3 months in cognitive performance as ascertained by Clox-1 and the Dementia Rating Scale, and their caregivers reported improvement in Neuropsychiatric Inventory. Participants receiving NF either continued to improve or maintained their baseline performance during open-label extensions. Participants randomized to placebo did not improve, but during open-label extensions displayed similar improvement within 3 months to that of participants initially randomized to NF. Caregivers reported no change in Activities of Daily Living for either cohort. Conclusions: These findings confirm and extend prior phase I studies in which NF improved or maintained cognitive performance and behavioral symptoms for individuals with AD, and improved cognitive performance for community-dwelling individuals without dementia. In published studies with transgenic mice NF reduced PS-1 expression, beta and gamma secretase activity, Abeta deposits, phospho-tau, homocysteine and oxidative damage, and increased acetylcholine and glutathione. This comprehensive impact of NF on AD-related neuropathology supports the possibility that NF may harbor disease-modifying properties

Supernova hydrodynamics experiments on Nova

We are developing experiments using the Nova laser to investigate (1) compressible nonlinear hydrodynamic mixing relevant to the first few hours of the supernova (SN) explosion and (2) ejecta-ambient plasma interactions relevant to the early SN remnant phase. The experiments and astrophysical implications are discussed. We discuss additional experiments possible with ultra-high-intensity lasers. © 1998 American Institute of Physics.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/87451/2/551_1.pd