Úloha galektinů v invazivitě nádorových buněk

Galectins are family of β-galactosidase binding proteins that serve many functions in all kind of mammalian cells. In the past years galectins, namely galectin-1 and galectin-3, have been revealed to play a major role in various cancer processes including cancer cell invasiveness, a process indispensable for the formation of metastasis. Both extracellular and intracellular forms of galectins modify the process of invasiveness in various ways, through interacting with different components of the cell or of the cell signalling pathways. The aim of this bachelor's thesis is to summarize mechanisms by which galectins promote cancer cell invasiveness. Keywords: galectins, galectin-1, galectin-3, invasiveness, cancer, metastasisGalektiny jsou skupinou proteinů vázajících β-galaktozidázu, které mají mnoho funkcí ve všech druzích savčích buněk. V uplynulých letech se ukázalo, že galektiny, jmenovitě galektin-1 a galektin-3, mají důležitou roli v procesech nádorové progrese, včetně invazivity nádorových buněk, procesu nezbytného pro tvorbu metastáz. Jak extracelulární, tak intracelulární formy galektinů modifikují proces invazivity různými způsoby, a to interakcí s různými komponentami buňky nebo buněčných signalizačních drah. Cílem této bakalářské práce je shrnout mechanismy, kterými galektiny zvyšují invazivitu nádorových buněk. Klíčová slova: galektiny, galektin-1, galektin-3, invazivita, nádorová onemocnění, metastázyDepartment of Cell BiologyKatedra buněčné biologieFaculty of SciencePřírodovědecká fakult

The role of galectins in cancer cell invasiveness

Galectins are family of β-galactosidase binding proteins that serve many functions in all kind of mammalian cells. In the past years galectins, namely galectin-1 and galectin-3, have been revealed to play a major role in various cancer processes including cancer cell invasiveness, a process indispensable for the formation of metastasis. Both extracellular and intracellular forms of galectins modify the process of invasiveness in various ways, through interacting with different components of the cell or of the cell signalling pathways. The aim of this bachelor's thesis is to summarize mechanisms by which galectins promote cancer cell invasiveness. Keywords: galectins, galectin-1, galectin-3, invasiveness, cancer, metastasi

The Technical Monuments in Křivoklát Region And How to Use Them in Primary School Education

The Diploma Thesis is focused on the technical monuments in Křivoklátsko region which are used in the education at primary school via educational excursions. The theoretical part of my Diploma Thesis concentrates on the technical education and its position at primary school. It also concerns the technical monuments, their typology, protection, and the declaration of the monuments as technical monuments of Křivoklátsko. The final part is dedicated to ten technical monuments in Křivoklátsko. The practical part of my Diploma Thesis contains particular educational excursions to the chosen technical monuments which are aimed to the education at primary school. The information background for teachers is the part of each educational excursion. The final section of the practical part is focused on the indicative verification of use of the educational excursions at primary school