195 research outputs found
Relaxation time spectrum of low-energy excitations in one- and two-dimensional materials with charge or spin density waves
The long-time thermal relaxation of (TMTTF)Br, SrCuO
and SrCaCuO single crystals at temperatures below 1 K
and magnetic field up to 10 T is investigated. The data allow us to determine
the relaxation time spectrum of the low energy excitations caused by the
charge-density wave (CDW) or spin-density wave (SDW). The relaxation time is
mainly determined by a thermal activated process for all investigated
materials. The maximum relaxation time increases with increasing magnetic
field. The distribution of barrier heights corresponds to one or two Gaussian
functions. The doping of SrCaCuO with Ca leads to
a drastic shift of the relaxation time spectrum to longer time. The maximum
relaxation time changes from 50 s (x = 0) to 3000 s (x = 12) at 0.1 K and 10 T.
The observed thermal relaxation at x=12 clearly indicates the formation of the
SDW ground state at low temperatures
Strong-Pinning Effects in Low-Temperature Creep: Charge-Density Waves in TaS_3
Nonlinear conduction in the quasi-one dimensional conductor o-TaS_3 has been
studied in the low-temperature region down to 30 mK. It was found that at
temperatures below a few Kelvins the current-voltage (I-V) characteristics
consist of several branches. The temperature evolution of the I-V curve
proceeds through sequential freezing-out of the branches. The origin of each
branch is attributed to a particular strong pinning impurity type.
Similar behavior is expected for other physical systems with collective
transport (spin-density waves, Wigner crystals, vortex lattices in type-II
superconductors etc.) in the presence of strong pinning centers.Comment: 11 pages, 3 ps figures, Revtex, To be published in Phys. Rev. Letters
(1997
Post-Disaster Housing Reconstruction in Sri Lanka: What Methodology?
Research methodology is the procedural framework within which the research is conducted. This includes the overall
approach to a problem that could be put into practice in a research process, from the theoretical underpinning to the
collection and analysis of data. Choice of methodology depends on the primary drivers: topic to be researched and the
specific research questions. Hence, methodological perspectives of managing stakeholder expectations of PDHR context
are composed of research philosophies, research strategy, research design, and research techniques. This research belonged
to social constructivism or interpretivism within a philosophical continuum. The nature of the study was more toward
subjectivism where human behavior favored voluntary stance. Ontological, methodological, epistemological, and axiological
positioning carried the characteristics of idealism, ideographic, anti-positivism, and value laden, respectively. Data collection
comprises two phases, preliminary and secondary. Exploratory interviews with construction experts in the United Kingdom
and Sri Lanka were carried out to refine the interview questions and identify the case studies. Case study interviews during
the secondary phase took place in Sri Lanka. Data collected at the preliminary stage were used to assess the attributes of
power, legitimacy/proximity, and urgency of stakeholders to the project using Stakeholder Circle™ software. Moreover,
the data collected at secondary phase via case studies will be analyzed with NVivo 8. This article aims to discuss these
methodological underpinnings in detail applied in a post-disaster housing reconstruction context in Sri Lanka
miR-132/212 knockout mice reveal roles for these miRNAs in regulating cortical synaptic transmission and plasticity
miR-132 and miR-212 are two closely related miRNAs encoded in the same intron of a small non-coding gene, which have been suggested to play roles in both immune and neuronal function. We describe here the generation and initial characterisation of a miR-132/212 double knockout mouse. These mice were viable and fertile with no overt adverse phenotype. Analysis of innate immune responses, including TLR-induced cytokine production and IFNβ induction in response to viral infection of primary fibroblasts did not reveal any phenotype in the knockouts. In contrast, the loss of miR-132 and miR-212, while not overtly affecting neuronal morphology, did affect synaptic function. In both hippocampal and neocortical slices miR-132/212 knockout reduced basal synaptic transmission, without affecting paired-pulse facilitation. Hippocampal long-term potentiation (LTP) induced by tetanic stimulation was not affected by miR-132/212 deletion, whilst theta burst LTP was enhanced. In contrast, neocortical theta burst-induced LTP was inhibited by loss of miR-132/212. Together these results indicate that miR-132 and/or miR-212 play a significant role in synaptic function, possibly by regulating the number of postsynaptic AMPA receptors under basal conditions and during activity-dependent synaptic plasticity
The neodymium isotope fingerprint of Adélie coast bottom water
Adélie Land Bottom Water (ALBW), a variety of Antarctic Bottom Water formed off the Adélie Land coast of East Antarctica, ventilates the abyssal layers of the Australian sector of the Southern Ocean as well as the eastern Indian and Pacific Oceans. We present the first dissolved neodymium (Nd) isotope and concentration measurements for ALBW. The summertime signature of ALBW is characterized by εNd = −8.9, distinct from Ross Sea Bottom Water, and similar to Weddell Sea Bottom Water. Adélie Land Shelf Water, the precursor water mass for wintertime ALBW, features the least radiogenic Nd fingerprint observed around Antarctica to date (εNd = −9.9). Local geology around Antarctica is important in setting the chemical signature of individual varieties of Antarctic Bottom Water, evident from the shelf water signature, which should be considered in the absence of direct wintertime observations
EMSY expression affects multiple components of the skin barrier with relevance to atopic dermatitis
CARM1 Mediates Modulation of Sox2
Sox2 is a key component of the transcription factor network that maintains the pluripotent state of embryonic stem cells (ESCs). Sox2 is regulated by multiple post-translational modifications, including ubiquitination, sumoylation, acetylation and phosphorylation. Here we report that Sox2 is in association with and methylated by coactivator-associated arginine methyltransferase 1 (CARM1), a protein arginine methyltransferase that plays a pivotal role in ESCs. We found that CARM1 facilitates Sox2-mediated transactivation and directly methylates Sox2 at arginine 113. This methylation event enhances Sox2 self-association. Furthermore, the physiological retention of Sox2 on chromatin restricts the Sox2 methylation level. Our study reveals the direct regulation of Sox2 by CARM1 that sheds lights on how arginine methylation signals are integrated into the pluripotent transcription factor network
Large-Scale Discovery and Characterization of Protein Regulatory Motifs in Eukaryotes
The increasing ability to generate large-scale, quantitative proteomic data has brought with it the challenge of analyzing such data to discover the sequence elements that underlie systems-level protein behavior. Here we show that short, linear protein motifs can be efficiently recovered from proteome-scale datasets such as sub-cellular localization, molecular function, half-life, and protein abundance data using an information theoretic approach. Using this approach, we have identified many known protein motifs, such as phosphorylation sites and localization signals, and discovered a large number of candidate elements. We estimate that ∼80% of these are novel predictions in that they do not match a known motif in both sequence and biological context, suggesting that post-translational regulation of protein behavior is still largely unexplored. These predicted motifs, many of which display preferential association with specific biological pathways and non-random positioning in the linear protein sequence, provide focused hypotheses for experimental validation
Functional cyclophilin D moderates platelet adhesion, but enhances the lytic resistance of fibrin
In the course of thrombosis, platelets are exposed to a variety of activating stimuli classified as ‘strong’ (e.g. thrombin and collagen) or ‘mild’ (e.g. ADP). In response, activated platelets adhere to injured vasculature, aggregate, and stabilise the three-dimensional fibrin scaffold of the expanding thrombus. Since ‘strong’ stimuli also induce opening of the mitochondrial permeability transition pore (MPTP) in platelets, the MPTP-enhancer Cyclophilin D (CypD) has been suggested as a critical pharmacological target to influence thrombosis. However, it is poorly understood what role CypD plays in the platelet response to ‘mild’ stimuli which act independently of MPTP. Furthermore, it is unknown how CypD influences platelet-driven clot stabilisation against enzymatic breakdown (fibrinolysis). Here we show that treatment of human platelets with Cyclosporine A (a cyclophilin-inhibitor) boosts ADP-induced adhesion and aggregation, while genetic ablation of CypD in murine platelets enhances adhesion but not aggregation. We also report that platelets lacking CypD preserve their integrity in a fibrin environment, and lose their ability to render clots resistant against fibrinolysis. Our results indicate that CypD has opposing haemostatic roles depending on the stimulus and stage of platelet activation, warranting a careful design of any antithrombotic strategy targeting CypD
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