Genetic and Vascular Risk Factors for Cognitive Decline and Cerebral Small-Vessel Disease

One of the earliest known written reports on dementia is attributed to Pythagoras in the 7th century BC, who described old age as a period of decline and decay of the human body and regression of mental capacities. In 1907, Alois Alzheimer, a german psychiatrist and scientist, observed at necropsy an overload of - at that time still unknown - amyloid plaques and neurofi brillary tangles in the brain of a 51 year old woman who had suff ered during her life course from progressive cognitive decline. Nowadays, amyloid plaques and neurofi brillary tangles are considered the main neuropathological hallmarks of Alzheimer’s disease, which is regarded the most frequent subtype of dementia. Over the past two decades evidence has been accumulating that dementia is a heterogeneous and multifactorial disorder, and that besides accumulation of beta amyloid and neurofi brillary tangles, other factors, in particular vascular risk factors and cerebrovascular disease, may be involved, especially in late-onset dementia. Observational studies reported associations between several vascular risk factors and cognitive decline and dementia. In autopsy studies, about 35% of the brains of elderly persons, who had been diagnosed with dementia during their lifetime, had not only a higher burden of amyloid plaques and neurofi brillar tangles but rather a mixed pathology also consisting of signifi cant cerebrovascular disease. Stroke has been reported to considerably increase the risk of dementia, with prevalence rates of poststroke dementia of about 30%, refl ecting a 3.6 to 5.8-fold increased risk of dementia compared to stroke-free subjects. Cerebral small-vessel disease, which is defi ned as cerebral white matter lesions and asymptomatic lacunar brain infarcts and is a common fi nding on brain scans of elderly persons, has been reported to more than double the risk of dementia

On the nonlinear influence of Reserve Bank of Australia interventions on exchange rates

This paper applies nonlinear econometric models to empirically investigate the effectiveness of the Reserve Bank of Australia (RBA) exchange rate policy. First, results from a STARTZ model are provided revealing nonlinear mean reversion of the Australian dollar exchange rate in the sense that mean reversion increases with the degree of exchange rate misalignment. Second, a STR-GARCH model suggests that RBA interventions account for this result by strengthening foreign exchange traders' confidence in fundamental analysis. This in line with the so-called coordination channel of intervention effectiveness. --Foreign exchange intervention,market microstructure,smooth transition,nonlinear mean reversion

Thermoluminescence fading studies: Implications for long-duration space measurements in Low Earth Orbit

Within a 1.5 year comprehensive fading experiment several batches of LiF:Mg,Ti and LiF:Mg,Cu,P thermoluminescence detectors (TLDs) were studied. The TLDs originated from two manufacturers and were processed by three laboratories using different annealing and readout conditions. The TLDs were irradiated with two radiation modalities (gamma-rays and thermal neutrons) and were stored at two temperatures (-17.4C and +18.5C). The goal of the experiment was to verify the stability of TLDs in the context of their application in long-term measurements in space. The results revealed that the response of all TLDs is stable within 10% for the studied temperature range. No influence of the radiation type was found. These results indicate that for the properly oven-annealed LiF TLDs, fading is not a significant problem, even for measuring periods longer than a year

Coherence properties of nanofiber-trapped cesium atoms

We experimentally study the ground state coherence properties of cesium atoms in a nanofiber-based two-color dipole trap, localized 200 nm away from the fiber surface. Using microwave radiation to coherently drive the clock transition, we record Ramsey fringes as well as spin echo signals and infer a reversible dephasing time $T_2^\ast=0.6$ ms and an irreversible dephasing time $T_2^\prime=3.7$ ms. By theoretically modelling the signals, we find that, for our experimental parameters, $T_2^\ast$ and $T_2^\prime$ are limited by the finite initial temperature of the atomic ensemble and the heating rate, respectively. Our results represent a fundamental step towards establishing nanofiber-based traps for cold atoms as a building block in an optical fiber quantum network

Electromagnetic wave scattering by a superconductor

The interaction between radiation and superconductors is explored in this paper. In particular, the calculation of a plane standing wave scattered by an infinite cylindrical superconductor is performed by solving the Helmholtz equation in cylindrical coordinates. Numerical results computed up to $\mathcal{O}(77)$ of Bessel functions are presented for different wavelengths showing the appearance of a diffraction pattern.Comment: 3 pages, 3 figure

Back-Scattering Properties of a Waveguide-Coupled Array of Atoms in the Strongly Non-Paraxial Regime

We experimentally investigate the back-scattering properties of an array of atoms that is evanescently coupled to an optical nanofiber in the strongly non-paraxial regime. We observe that the power and the polarization of the back-scattered light depend on the nanofiber-guided excitation field in a way that significantly deviates from the predictions of a simple model based on two-level atoms and a scalar waveguide. Even though it has been widely used in previous experimental and theoretical studies of waveguide-coupled quantum emitters, this simple model is thus in general not adequate even for a qualitative description of such systems. We develop an ab initio model which includes the multi-level structure of the atoms and the full vectorial properties of the guided field and find very good agreement with our data

Poynting's theorem for planes waves at an interface: a scattering matrix approach

We apply the Poynting theorem to the scattering of monochromatic electromagnetic planes waves with normal incidence to the interface of two different media. We write this energy conservation theorem to introduce a natural definition of the scattering matrix S. For the dielectric-dielectric interface the balance equation lead us to the energy flux conservation which express one of the properties of S: it is a unitary matrix. For the dielectric-conductor interface the scattering matrix is no longer unitary due to the presence of losses at the conductor. However, the dissipative term appearing in the Poynting theorem can be interpreted as a single absorbing mode at the conductor such that a whole S, satisfying flux conservation and containing this absorbing mode, can be defined. This is a simplest version of a model introduced in the current literature to describe losses in more complex systems.Comment: 5 pages, 3 figures, submitted to Am. J. Phy

Optical interface created by laser-cooled atoms trapped in the evanescent field surrounding an optical nanofiber

Trapping and optically interfacing laser-cooled neutral atoms is an essential requirement for their use in advanced quantum technologies. Here we simultaneously realize both of these tasks with cesium atoms interacting with a multi-color evanescent field surrounding an optical nanofiber. The atoms are localized in a one-dimensional optical lattice about 200 nm above the nanofiber surface and can be efficiently interrogated with a resonant light field sent through the nanofiber. Our technique opens the route towards the direct integration of laser-cooled atomic ensembles within fiber networks, an important prerequisite for large scale quantum communication schemes. Moreover, it is ideally suited to the realization of hybrid quantum systems that combine atoms with, e.g., solid state quantum devices

The ALTCRISS project on board the International Space Station

The Altcriss project aims to perform a long term survey of the radiation environment on board the International Space Station. Measurements are being performed with active and passive devices in different locations and orientations of the Russian segment of the station. The goal is to perform a detailed evaluation of the differences in particle fluence and nuclear composition due to different shielding material and attitude of the station. The Sileye-3/Alteino detector is used to identify nuclei up to Iron in the energy range above 60 MeV/n. Several passive dosimeters (TLDs, CR39) are also placed in the same location of Sileye-3 detector. Polyethylene shielding is periodically interposed in front of the detectors to evaluate the effectiveness of shielding on the nuclear component of the cosmic radiation. The project was submitted to ESA in reply to the AO in the Life and Physical Science of 2004 and data taking began in December 2005. Dosimeters and data cards are rotated every six months: up to now three launches of dosimeters and data cards have been performed and have been returned with the end of expedition 12 and 13.Comment: Accepted for publication on Advances in Space Research http://dx.doi.org/10.1016/j.asr.2007.04.03

Effects of geometric anisotropy on local field distribution: Ewald-Kornfeld formulation

We have applied the Ewald-Kornfeld formulation to a tetragonal lattice of point dipoles, in an attempt to examine the effects of geometric anisotropy on the local field distribution. The various problems encountered in the computation of the conditionally convergent summation of the near field are addressed and the methods of overcoming them are discussed. The results show that the geometric anisotropy has a significant impact on the local field distribution. The change in the local field can lead to a generalized Clausius-Mossotti equation for the anisotropic case.Comment: Accepted for publications, Journal of Physics: Condensed Matte