Resultate einer coleopterologischen Sammel-Campagne während den Monaten Februar bis April 1883 auf den jonischen Inseln

Mein Freund Ernst Brenske, der sich auf seiner Tour nach Morea im November 1881 auf meinen Rath zwei Wochen in Corfu aufhielt um dort Coleopteren zu sieben, fand während dieser Zeit 5 neue Pselaphiden - und Scydmaeniden-Arten, welche in mir den Wunsch rege werden liessen, dieselben gelegentlich in grösserer Anzahl zu sammeln. Diesem Vorhaben konnte ich schon heuer entsprechen, da meine angegriffene Gesundheit es nothwendig machte, den Rest des Winters in einem milderen Klima zu verbringen. ..

A lesson for cancer research : placental microarray gene analysis in preeclampsia

Tumor progression and pregnancy share many common features, such as immune tolerance and invasion. The invasion of trophoblasts in the placenta into the uterine wall is essential for fetal development, and is thus precisely regulated. Its deregulation has been implicated in preeclampsia, a leading cause for maternal and perinatal mortality and morbidity. Pathogenesis of preeclampsia remains to be defined. Microarray-based gene profiling has been widely used for identifying genes responsible for preeclampsia. In this review, we have summarized the recent data from the microarray studies with preeclamptic placentas. Despite the complex of gene signatures, suggestive of the heterogeneity of preeclampsia, these studies identified a number of differentially expressed genes associated with preeclampsia. Interestingly, most of them have been reported to be tightly involved in tumor progression. We have discussed these interesting genes and analyzed their potential molecular functions in preeclampsia, compared with their roles in malignancy development. Further investigations are warranted to explore the involvement in molecular network of each identified gene, which may provide not only novel strategies for prevention and therapy for preeclampsia but also a better understanding of cancer cells. The trophoblastic cells, with their capacity for proliferation and differentiation, apoptosis and survival, migration, angiogenesis and immune modulation by exploiting similar molecular pathways, make them a compelling model for cancer research

Learning Simpler Language Models with the Differential State Framework

Learning useful information across long time lags is a critical and difficult problem for temporal neural models in tasks such as language modeling. Existing architectures that address the issue are often complex and costly to train. The Differential State Framework (DSF) is a simple and high-performing design that unifies previously introduced gated neural models. DSF models maintain longer-term memory by learning to interpolate between a fast-changing data-driven representation and a slowly changing, implicitly stable state. This requires hardly any more parameters than a classical, simple recurrent network. Within the DSF framework, a new architecture is presented, the Delta-RNN. In language modeling at the word and character levels, the Delta-RNN outperforms popular complex architectures, such as the Long Short Term Memory (LSTM) and the Gated Recurrent Unit (GRU), and, when regularized, performs comparably to several state-of-the-art baselines. At the subword level, the Delta-RNN's performance is comparable to that of complex gated architectures.Comment: Edits/revisions applied throughout documen

Fauna Germanica : die Käfer des Deutschen Reiches : nach der analytischen Methode ; Bd. 1-5

Vom Vorstande des Deutschen Lehrer-Vereins für Naturkunde ist mir der ehrenvolle Auftrag zu teil geworden, für die Mitglieder dieses grossen und angesehenen Vereins eine Käferfauna von Deutschland zu bearbeiten. ..

Novel approach for deriving genome wide SNP analysis data from archived blood spots.

RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are.BACKGROUND: The ability to transport and store DNA at room temperature in low volumes has the advantage of optimising cost, time and storage space. Blood spots on adapted filter papers are popular for this, with FTA (Flinders Technology Associates) Whatman™TM technology being one of the most recent. Plant material, plasmids, viral particles, bacteria and animal blood have been stored and transported successfully using this technology, however the method of porcine DNA extraction from FTA Whatman™TM cards is a relatively new approach, allowing nucleic acids to be ready for downstream applications such as PCR, whole genome amplification, sequencing and subsequent application to single nucleotide polymorphism microarrays has hitherto been under-explored. FINDINGS: DNA was extracted from FTA Whatman™TM cards (following adaptations of the manufacturer's instructions), whole genome amplified and subsequently analysed to validate the integrity of the DNA for downstream SNP analysis. DNA was successfully extracted from 288/288 samples and amplified by WGA. Allele dropout post WGA, was observed in less than 2% of samples and there was no clear evidence of amplification bias nor contamination. Acceptable call rates on porcine SNP chips were also achieved using DNA extracted and amplified in this way. CONCLUSIONS: DNA extracted from FTA Whatman cards is of a high enough quality and quantity following whole genomic amplification to perform meaningful SNP chip studies

A Computational Cognitive Model of Syntactic Priming

The psycholinguistic literature has identified two syntactic adaptation effects in language production: rapidly decaying short-term priming and long-lasting adaptation. To explain both effects, we present an ACT-R model of syntactic priming based on a wide-coverage, lexicalized syntactic theory that explains priming as facilitation of lexical access. In this model, two well-established ACT-R mechanisms, base-level learning and spreading activation, account for long-term adaptation and short-term priming, respectively. Our model simulates incremental language production and in a series of modeling studies we show that it accounts for (a) the inverse frequency interaction; (b) the absence of a decay in long-term priming; and (c) the cumulativity of long-term adaptation. The model also explains the lexical boost effect and the fact that it only applies to short-term priming. We also present corpus data that verifies a prediction of the model, i.e., that the lexical boost affects all lexical material, rather than just heads. Keywords: syntactic priming, adaptation, cognitive architectures, ACT-R, categorial grammar, incrementality