Maine’s Workers’ Compensation System: Is it Making the Grade?

Fundamental changes in Maine’s workers\u27 compensation system were legislated four years ago. What impact have they had and what remains on the policy agenda? This article provides a comprehensive and balanced assessment of that reform effort, suggesting dramatic improvements in the system. But work remains: Vocational rehabilitation, labor-management collaboration, and cost-containment are especially in need of improvement

Flight data analysis of power subsystem degradation at near synchronous altitude Quarterly report

Flight data analysis of spacecraft power subsystem degradation at near synchronous altitud

Flight data analysis of power subsystem degradation at near synchronous altitude Final report

Comparison and analysis of radiation damage to power supplies of satellites at near-synchronous altitude

Public Collaboration in Maine: When and Why It Works

Government by itself cannot address all complex public policy issues. The authors write that “public collabo­ration” can alter the discourse on divisive local, regional, and state issues. Public collaboration is a process in which people from multiple sectors (government, business, nonprofit, civic, and tribal) work together to find solutions to problems that no single sector is able to resolve on its own. The authors describe the common features of effective public collaboration and provide detailed case studies and analysis of five recent examples of public collaboration in Maine

Is Social Psychology Really Different?

Gergen (1976), outlines a number of problems that make it difficult to apply general social psychological the ories, or to assess their validity unequivocally. These dif ficulties are not unique to social psychology, however. The application of general scientific principles has never been a simple matter, not even in the well-established physical sci ences. Moreover, there are formidable difficulties in asses sing general theoretical propositions in every field of in quiry, since empirical procedures will inevitably depend on assumptions about local field conditions, the adequacy of meas urement techniques, and the like. As a consequence, if re sults are inconsistent with theoretical expectations, there will always be some uncertainty as to where the problem lies. Social psychologists should not assume that their difficulties are totally unlike those encountered in other fields of sci entific inquiry. The problems raised by Gergen do not, con sequently, rule out the possible development and application of general social psychological theories.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/69124/2/10.1177_014616727600200417.pd

Psychotherapy in historical perspective

This article will briefly explore some of the ways in which the past has been used as a means to talk about psychotherapy as a practice and as a profession, its impact on individuals and society, and the ethical debates at stake. It will show how, despite the multiple and competing claims about psychotherapy’s history and its meanings, historians themselves have, to a large degree, not attended to the intellectual and cultural development of many therapeutic approaches. This absence has the potential consequence of implying that therapies have emerged as value-free techniques, outside of a social, economic and political context. The relative neglect of psychotherapy, by contrast with the attention historians have paid to other professions, particularly psychiatry, has also underplayed its societal impact. This article will foreground some of the instances where psychotherapy has become an object of emerging historical interest, including the new research that forms the substance of this special issue of History of the Human Sciences

Neurology

Contains reports on eight research projects.U.S. Navy (Office of Naval Research (Nonr-1841(70))U. S. Public Health Service (MH-06175-02)U. S. Air Force (AF49(638)-1313)U. S. Public Health Service (B-3055-4)U. S. Public Health Service (B-3090-4

Screen for IDH1, IDH2, IDH3, D2HGDH and L2HGDH Mutations in Glioblastoma

Isocitrate dehydrogenases (IDHs) catalyse oxidative decarboxylation of isocitrate to α-ketoglutarate (α-KG). IDH1 functions in the cytosol and peroxisomes, whereas IDH2 and IDH3 are both localized in the mitochondria. Heterozygous somatic mutations in IDH1 occur at codon 132 in 70% of grade II–III gliomas and secondary glioblastomas (GBMs), and in 5% of primary GBMs. Mutations in IDH2 at codon 172 are present in grade II–III gliomas at a low frequency. IDH1 and IDH2 mutations cause both loss of normal enzyme function and gain-of-function, causing reduction of α-KG to D-2-hydroxyglutarate (D-2HG) which accumulates. Excess hydroxyglutarate (2HG) can also be caused by germline mutations in D- and L-2-hydroxyglutarate dehydrogenases (D2HGDH and L2HGDH). If loss of IDH function is critical for tumourigenesis, we might expect some tumours to acquire somatic IDH3 mutations. Alternatively, if 2HG accumulation is critical, some tumours might acquire somatic D2HGDH or L2HGDH mutations. We therefore screened 47 glioblastoma samples looking for changes in these genes. Although IDH1 R132H was identified in 12% of samples, no mutations were identified in any of the other genes. This suggests that mutations in IDH3, D2HGDH and L2HGDH do not occur at an appreciable frequency in GBM. One explanation is simply that mono-allelic IDH1 and IDH2 mutations occur more frequently by chance than the bi-allelic mutations expected at IDH3, D2HGDH and L2HGDH. Alternatively, both loss of IDH function and 2HG accumulation might be required for tumourigenesis, and only IDH1 and IDH2 mutations have these dual effects