The role of visual and mechanosensory cues in structuring forward flight in Drosophila melanogaster

It has long been known that many flying insects use visual cues to orient with respect to the wind and to control their groundspeed in the face of varying wind conditions. Much less explored has been the role of mechanosensory cues in orienting insects relative to the ambient air. Here we show that Drosophila melanogaster, magnetically tethered so as to be able to rotate about their yaw axis, are able to detect and orient into a wind, as would be experienced during forward flight. Further, this behavior is velocity dependent and is likely subserved, at least in part, by the Johnston's organs, chordotonal organs in the antennae also involved in near-field sound detection. These wind-mediated responses may help to explain how flies are able to fly forward despite visual responses that might otherwise inhibit this behavior. Expanding visual stimuli, such as are encountered during forward flight, are the most potent aversive visual cues known for D. melanogaster flying in a tethered paradigm. Accordingly, tethered flies strongly orient towards a focus of contraction, a problematic situation for any animal attempting to fly forward. We show in this study that wind stimuli, transduced via mechanosensory means, can compensate for the aversion to visual expansion and thus may help to explain how these animals are indeed able to maintain forward flight

Enhanced imaging of microcalcifications in digital breast tomosynthesis through improved image-reconstruction algorithms

PURPOSE: We develop a practical, iterative algorithm for image-reconstruction in under-sampled tomographic systems, such as digital breast tomosynthesis (DBT). METHOD: The algorithm controls image regularity by minimizing the image total $p$-variation (TpV), a function that reduces to the total variation when $p=1.0$ or the image roughness when $p=2.0$. Constraints on the image, such as image positivity and estimated projection-data tolerance, are enforced by projection onto convex sets (POCS). The fact that the tomographic system is under-sampled translates to the mathematical property that many widely varied resultant volumes may correspond to a given data tolerance. Thus the application of image regularity serves two purposes: (1) reduction of the number of resultant volumes out of those allowed by fixing the data tolerance, finding the minimum image TpV for fixed data tolerance, and (2) traditional regularization, sacrificing data fidelity for higher image regularity. The present algorithm allows for this dual role of image regularity in under-sampled tomography. RESULTS: The proposed image-reconstruction algorithm is applied to three clinical DBT data sets. The DBT cases include one with microcalcifications and two with masses. CONCLUSION: Results indicate that there may be a substantial advantage in using the present image-reconstruction algorithm for microcalcification imaging.Comment: Submitted to Medical Physic

Efficient operation of a high-power X-band gyroklystron

Experimental studies of amplification in a two-cavity X-band gyroklystron are reported. The system utilizes a thermionic magnetron injection gun at voltages up to 440 kV and currents up to 190 A in 1-μs pulses. Optimum performance is achieved by tapering the magnetic-field profile. Peak powers of 20 MW in the TE01 mode at 9.87 GHz are measured with calibrated crystals and with methanol calorimetry. Resultant efficiencies are in excess of 31% and large-signal gains surpass 26 dB. The experimental results are in good agreement with simulated results from a partially self-consistent, nonlinear, steady-state code

High-power operation of a K-band second harmonic gyroklystron

Amplification studies of a two-cavity second-harmonic gyroklystron are reported. A magnetron injection gun produces a 440 kV, 200–245 A, 1 μs beam with an average perpendicular-to-parallel velocity ratio slightly less than 1. The TE011 input cavity is driven near 9.88 GHz and the TE021 output cavity resonates near 19.76 GHz. Peak powers exceeding 21 MW are achieved with an efficiency near 21% and a large signal gain above 25 dB. This performance represents the current state of the art for gyroklystrons in terms of the peak power normalized to the output wavelength squared