28 research outputs found
Evaluation of disposable filtration systems for harvesting high cell density fed batch processes
Efficient computation of matched solutions of the Kapchinskij-Vladimirskij envelope equations for periodic focusing lattices
A new iterative method is developed to numerically calculate the periodic,
matched beam envelope solution of the coupled Kapchinskij-Vladimirskij (KV)
equations describing the transverse evolution of a beam in a periodic, linear
focusing lattice of arbitrary complexity. Implementation of the method is
straightforward. It is highly convergent and can be applied to all usual
parameterizations of the matched envelope solutions. The method is applicable
to all classes of linear focusing lattices without skew couplings, and also
applies to all physically achievable system parameters -- including where the
matched beam envelope is strongly unstable. Example applications are presented
for periodic solenoidal and quadrupole focusing lattices. Convergence
properties are summarized over a wide range of system parameters.Comment: 20 pages, 5 figures, Mathematica source code provide
Imaging characteristics of intravascular spherical contrast agents for grating-based x-ray dark-field imaging - effects of concentrations, spherical sizes and applied voltage
This study investigates the x-ray scattering characteristics of microsphere particles in x-ray-grating-based interferometric imaging at different concentrations, bubble sizes and tube voltages (kV). Attenuation (ATI), dark-field (DFI) and phase-contrast (PCI) images were acquired. Signal-to-noise (SNR) and contrast-to-noise ratios with water (CNRw) and air as reference (CNRa) were determined. In all modalities, a linear relationship between SNR and microbubbles concentration, respectively, microsphere size was found. A significant gain of SNR was found when varying kV. SNR was significantly higher in DFI and PCI than ATI. The highest gain of SNR was shown at 60kV for all media in ATI and DFI, at 80kV for PCI. SNR for all media was significantly higher compared to air and was slightly lower compared to water. A linear relationship was found between CNRa, CNRw, concentration and size. With increasing concentration and decreasing size, CNRa and CNRw increased in DFI, but decreased in PCI. Best CNRa and CNRw was found at specific combination of kV and concentration/size. Highest average CNRa and CNRw was found for microspheres in ATI and PCI, for microbubbles in DFI. Microspheres are a promising contrast-media for grating-based-interferometry, if kV, microsphere size and concentration are appropriately combined
Innovative 1000K sodium loop for qualification of new materials for applications in CSP field
Assessing Pulmonary Perfusion in Emphysema Automated Quantification of Perfused Blood Volume in Dual-Energy CTPA
Objectives: The objective of this study was to determine whether automated quantification of lung perfused blood volume (PBV) in dual-energy computed tomographic pulmonary angiography (DE-CTPA) can be used to assess the severity and regional distribution of pulmonary hypoperfusion in emphysema. Materials and Methods: We retrospectively analyzed 40 consecutive patients (mean age, 67 13] years) with pulmonary emphysema, who have no cardiopulmonary comorbidities, and a DE-CTPA negative for pulmonary embolism. Automated quantification of global and regional pulmonary PBV was performed using the syngo Dual Energy application (Siemens Healthcare). Similarly, the global and regional degrees of parenchymal hypodensity were assessed automatically as the percentage of voxels with a computed tomographic density less than -900 Hounsfield unit. Emphysema severity was rated visually, and pulmonary function tests were obtained by chart review, if available. Results: Global PBV generated by automated quantification of pulmonary PBV in the DE-CTPA data sets showed a moderately strong but highly significant negative correlation with residual volume in percentage of the predicted residual volume (r = -0.62; P = 0.002; n = 23) and a positive correlation with forced expiratory volume in 1 second in percentage of the predicted forced expiratory volume in 1 second (r = 0.67; P < 0.001; n = 23). Global PBV values strongly correlated with diffusing lung capacity for carbon monoxide (r = 0.80; P < 0.001; n = 15). Pulmonary PBV values decreased with visual emphysema severity (r = -0.46, P = 0.003, n = 40). Moderate negative correlations were found between global PBV values and parenchymal hypodensity both in a per-patient (r = -0.63; P G 0.001; n = 40) and per-region analyses (r = -0.62; P < 0.001; n = 40). Conclusions: Dual-energy computed tomographic pulmonary angiography allows simultaneous assessment of lung morphology, parenchymal density, and pulmonary PBV. In patients with pulmonary emphysema, automated quantification of pulmonary PBV in DE-CTPA can be used for a quick, reader-independent estimation of global and regional pulmonary perfusion, which correlates with several lung function parameters
Experimental and Numerical Process Design for Press Partitioning of the New Q&P Steel 37SiB6
Quenching and partitioning (Q&P) heat treatments of low-alloy steels with exceptional property combinations are particularly promising. In this study, we characterize for the first time a new low-alloy steel to be processed using Q&P heat treatments. In combined experimental and numerical studies, we design a novel approach that effectively combines the short cycle times of press hardening with the excellent property profiles of Q&P-treated steels. We identify an appropriate austenization temperature of 950 °C and a portioning temperature of 250 °C for Q&P heat treatments through dilatometric studies. We adjust a number of reference conditions with fractions of 2.1 to 6.3 wt.% of retained austenite, resulting in tensile strengths up to 1860 MPa and elongations to failure up to 7%. Initial numerical designs of the process can identify varying temperature profiles and cooling rates depending on the position in the die. The results show that the geometry of the part plays a minor role, but the die temperature of 200 °C is the dominant factor for successful partitioning directly in the press hardening process
Evaluation of the 6-F ExoSeal Vascular Closure Device in Antegrade Femoral Artery Punctures
Task-Based Mixed-Initiative Coordination
Lütkebohle I, Wachsmuth S. Task-Based Mixed-Initiative Coordination. In: Prassler E, Burgard W, Handmann U, et al., eds. Towards Service Robots for Everyday Environments. Springer Tracts in Advanced Robotics ; 76. Berlin, Heidelberg: Springer; 2012: 457-470.Interactive teaching is a coordinated activity in many different respects. This includes intra-personal aspects, like the joint production of speech and gestures, as well as inter-personal aspects, like the processing of verbal corrections while an action is performed. Given the experimental paradigm of human-robot interaction research, coordinated activities may be changed, added, or removed in an iterative manner. To keep the system maintainable despite coordination dependencies is an architectural challenge that is systematically analyzed in the following and supported by a toolkit. In many proposed robotic software architectures, coordination of active components that carry out tasks occurs through coupled statemachines that track the shared system state. This represents a generalizable software pattern that we have identified and analyzed in a general manner for the first time.
Furthermore, in mixed-initiative Human-Robot-Interaction, tasks can be initiated by either participant, causing the active and passive roles to change. Such changes have not been addressed before and we have generalized task coordination to encompass them. Last, but not least, distributed state tracking is complex, and previous implementations have thus often placed it entirely in a centralized coordination service that, however, increases coupling. Instead, we have developed a task service toolkit, which can be embedded in components, and demonstrated that this reduces component complexity considerably, without affecting coupling. Based on it, both centralized and de-centralized coordination services are possible