High dispersive and monolithic 100% efficiency grisms

We present a type of grism, a series combination of transmission grating and prism, in which we reduce the number of diffraction orders and achieve a configuration with very high angular dispersion. The grism can be fabricated from a single dielectric material and requires no metallic or dielectric film layers for high transmission diffraction efficiency. One can reach 100% in the -1st transmission diffraction order and the equal damage threshold as the dielectric bulk material. We realized such an element in fused silica with an efficiency of more then 99%. The bevel backside reflection is reduced by a statistical antireflective structure, so we measured an efficiency of the entire grism of 95% at a single wavelength

New technique for replica symmetry breaking with application to the SK-model at and near T=0

We describe a novel method which allows the treatment of high orders of replica-symmetry-breaking (RSB) at low temperatures as well as at T=0 directly, without a need for approximations or scaling assumptions. It yields the low temperature order function q(a,T) in the full range $0\leq a <\infty$ and is complete in the sense that all observables can be calculated from it. The behavior of some observables and the finite RSB theory itself is analyzed as one approaches continuous RSB. The validity and applicability of the traditional continuous formulation is then scrutinized and a new continuous RSB formulation is proposed

The Chandra X-Ray Observatory's Radiation Environment and the AP-8/AE-8 Model

The Chandra X-ray Observatory (CXO) was launched on July 23, 1999 and reached its final orbit on August 7, 1999. The CXO is in a highly elliptical orbit, approximately 140,000 km x 10,000 km, and has a period of approximately 63.5 hours (~ 2.65 days). It transits the Earth's Van Allen belts once per orbit during which no science observations can be performed due to the high radiation environment. The Chandra X-ray Observatory Center (CXC) currently uses the National Space Science Data Center's ``near Earth'' AP-8/AE-8 radiation belt model to predict the start and end times of passage through the radiation belts. However, our scheduling software uses only a simple dipole model of the Earth's magnetic field. The resulting B, L magnetic coordinates, do not always give sufficiently accurate predictions of the start and end times of transit of the Van Allen belts. We show this by comparing to the data from Chandra's on-board radiation monitor, the EPHIN (Electron, Proton, Helium Instrument particle detector) instrument. We present evidence that demonstrates this mis-timing of the outer electron radiation belt as well as data that also demonstrate the significant variablity of one radiation belt transit to the next as experienced by the CXO. We also present an explanation for why the dipole implementation of the AP-8/AE-8 model is not ideally suited for the CXO. Lastly, we provide a brief discussion of our on-going efforts to identify a model that accounts for radiation belt variability, geometry, and one that can be used for observation scheduling purposes.Comment: 12 pgs, 6 figs, for SPIE 4012 (Paper 76

Risk of basal cell carcinoma after Hodgkin's disease

Background: Basal cell cancer is a common skin cancer, yet studies of second tumors after Hodgkin's disease tend to exclude basal cell cancers as second malignant tumors from analysis. Basal cell carcinomas (BCC) are possibly more common in immunosuppressed patients and were recently implicated as indicators of subsequent malignancies. Materials and Methods: Our database of 1,120 patients with Hodgkin's disease (derived from the tumor registry) was investigated for the occurrence of later BCCs. Kaplan-Meier curves were calculated. Results: A total of 9 cases of BCC were observed 0-20 years after the diagnosis of Hodgkin's disease, One case relapsed after excision. The probability of second BCC was 2.1% after 15 years of follow-up and 7.1% after 20 years. Statistically, the risk for second BCC was increased only in younger patients and with prolonged follow-up, but not in the total group of patients with Hodgkin's disease. Conclusion: BCC is not a major threat: for the survivors of Hodgkin's disease, but continued follow-up is necessary

PMT Test Facility at MPIK Heidelberg and Double Chooz Super Vertical Slice

Proceedings supplement for conference poster at Neutrino 2010, Athens, Greece

Characteristic numbers of manifold bundles over surfaces with highly connected fibers

We study smooth bundles over surfaces with highly connected almost parallelizable fiber M of even dimension, providing necessary conditions for a manifold to be bordant to the total space of such a bundle and showing that, in most cases, these conditions are also sufficient. Using this, we determine the characteristic numbers realized by total spaces of bundles of this type, deduce divisibility constraints on their signatures and \hat{A}-genera, and compute the second integral cohomology of BDiff(M) up to torsion in terms of generalized Miller--Morita--Mumford classes. We also prove analogous results for topological bundles over surfaces with fiber $M$ and discuss the resulting obstructions to smoothing them

Strong Limit on a Variable Proton-to-Electron Mass Ratio from Molecules in the Distant Universe

The Standard Model of particle physics assumes that the so-called fundamental constants are universal and unchanging. Absorption lines arising in molecular clouds along quasar sightlines offer a precise test for variations in the proton-to-electron mass ratio, mu, over cosmological time and distance scales. The inversion transitions of ammonia are particularly sensitive to mu compared to molecular rotational transitions. Comparing the available ammonia spectra observed towards the quasar B0218+357 with new, high-quality rotational spectra, we present the first detailed measurement of mu with this technique, limiting relative deviations from the laboratory value to |dmu/mu| < 1.8x10^{-6} (95% confidence level) at approximately half the Universe's current age - the strongest astrophysical constraint to date. Higher-quality ammonia observations will reduce both the statistical and systematic uncertainties in these measurements.Comment: Science, 20th June 2008. 22 pages, 5 figures (12 EPS files), 2 tables, including Supporting Online Material; v2: Corrected reference for laboratory mu-variation bound

Advanced head and neck cancer: Long-term results of chemo-radiotherapy, complications and induction of second malignancies

Background: Chemo-radiotherapy is superior to radiotherapy alone in the treatment of advanced, inoperable head and neck cancer. The long-term treatment results, the induction of second malignant tumors, and other long-term toxicities are not well defined. Patients and Methods: 100 consecutive patients with advanced head and neck cancer who were treated at our center were studied. Treatment results, survival, the occurrence of late complications, and second malignant tumors (SMT) were investigated. 78 patients were treated with a protocol combining cisplatinum, 5-fluorouracil, folinic acid and hyper-fractionated irradiation. 22 patients were treated with other chemo-radiotherapy protocols. The relative risk of developing an SMT was compared with that within the normal population. Results: The cumulative total probability of survival was 51.1% at 2 years and 38.7% at 4 years. The probability of relapse-free survival was 39.9% at 2 years and 36.7% at 4 years. A total of 7 patients developed SMT (4 cases of lung cancer, 2 colon cancers, 1 skin cancer). After 6 years, a cumulative risk of SMT of 8.7% was observed. The relative risk of developing an SMT was significantly increased (4.45-fold in males) compared with a normal population. 13 of 38 evaluable patients (34.2%) had severe late complications like fibrosis of soft tissues, nerve lesions, or were dependent on tracheal cannulas. Conclusions: The treatment results and long-term prognoses in our population of unselected high-risk patients are unsatisfactory, but comparable to those from multicenter studies. About 35% of patients become long-term (> 4 years) survivors. SMT generally occur early, have a poor prognosis and, most likely, are not treatment-related. Approximately 30% of long-term survivors have severe, often incapacitating late effects. The treatment and - if possible - prevention of these late effects is important for the quality of life of patients who survived advanced head and neck cancer

Scattering theory of current-induced forces in mesoscopic systems

We develop a scattering theory of current-induced forces exerted by the conduction electrons of a general mesoscopic conductor on slow "mechanical" degrees of freedom. Our theory describes the current-induced forces both in and out of equilibrium in terms of the scattering matrix of the phase-coherent conductor. Under general nonequilibrium conditions, the resulting mechanical Langevin dynamics is subject to both non-conservative and velocity-dependent Lorentz-like forces, in addition to (possibly negative) friction. We illustrate our results with a two-mode model inspired by hydrogen molecules in a break junction which exhibits limit-cycle dynamics of the mechanical modes.Comment: 4+ pages, 1 figure; v2: minor modification