High incidence of Angina pectoris in patients treated with 5-fluorouracil - A planned surveillance study with 102 patients

Objective: Angina pectoris, arrhythmic sudden death and myocardial infarction, all these cardiac events have occasionally been reported during 5-fluorouracil (5-FU) chemotherapy. Underlying mechanisms leading to these events are unknown; damage to the myocytes or vasospasms have been discussed. Methods: 102 consecutive and unselected patients were monitored with 12-lead ECG, echocardiography and radionuclide ventriculography prior to the first cycle of 5-FU chemotherapy and 3 months from baseline. Results: 19% of the patients developed reversible symptoms of angina pectoris during treatment which lasted up to 12 h after cessation of the infusion. Most of the 19 patients showed corresponding ECG changes. 6 out of the 19 patients with severe angina pectoris had subsequent coronary angiography. In none of these patients the coronary angiography showed coronary artery disease, but it showed low ventricular function (ejection fraction <50%) in 2 patients. The ejection fraction did not increase overtime. Arrhythmias were screened for with Holter monitoring during 5-FU chemotherapy. The frequency of bradycardia and ventricular extrasystoles increased significantly (p < 0.05) during treatment compared to arrhythmias in Holter monitoring 3 months later. Furthermore the Qtc time in the ECG 3 months later was significantly prolonged (p < 0.05) compared to baseline values. Conclusions:The incidence of angina pectoris in patients during 5-FU treatment seems higher than previously suspected. As myocardial ischemia can be fatal, attentiveness to these symptoms and immediate treatment are crucial. Copyright (C) 2003 S. Karger AG, Basel

Twinning in muskox and the cytogenetic investigation of a freemartin

The occurrence of twinning has been documented for muskox in both wild and captive populations. Of two known captive twin births only one set survived beyond 120 days. In both cases the twins were male-female pairs and both females showed abnormal sexual development. Two sets of stillborn twins have also been recorded. All four stillborn fetuses were female and none showed anomalies of the reproductive tract upon post-mortem examination. Blood cultures from the surviving male and female twins revealed that both were chimeric, indicating the admixture of fetal blood. Fibroblast cultures were normal for the respective sex of each individual. The freemartin heifer had anatomical abnormalities of the clitoris as well as the secondary sex characteristics of a male

Highly indistinguishable single photons from incoherently and coherently excited GaAs quantum dots

Semiconductor quantum dots are converging towards the demanding requirements of photonic quantum technologies. Among different systems, quantum dots with dimensions exceeding the free-exciton Bohr radius are appealing because of their high oscillator strengths. While this property has received much attention in the context of cavity quantum electrodynamics, little is known about the degree of indistinguishability of single photons consecutively emitted by such dots and on the proper excitation schemes to achieve high indistinguishability. A prominent example is represented by GaAs quantum dots obtained by local droplet etching, which recently outperformed other systems as triggered sources of entangled photon pairs. On these dots, we compare different single-photon excitation mechanisms, and we find (i) a "phonon bottleneck" and poor indistinguishability for conventional excitation via excited states and (ii) photon indistinguishablilities above 90% for both strictly resonant and for incoherent acoustic- and optical-phonon-assisted excitation. Among the excitation schemes, optical phonon-assisted excitation enables straightforward laser rejection without a compromise on the source brightness together with a high photon indistinguishability

Socio-Emotional Resilience Among Older Adults During the COVID-19 Pandemic

The detrimental impact of social isolation on health and well-being has been reported in older adults (Prohaska, et al., 2020). Yet findings also demonstrate that older adults have a motivational shift to prioritize emotionally meaningful goals and experiences (Carstensen, 1993; Sakaki, et al., 2019), prioritize emotional meaning in situations, focus on positive emotions and stimuli over negative feelings and live in the present rather than focus on future preparedness. Socioemotional selectivity theory (SST) (Carstensen, 1993; Carstensen, Fung & Charles, 2003) suggests that older adults have a limited sense of time left in life and shift their focus to meaningful and positive experiences. Due to the COVID-19 pandemic most individuals became physically separated from family, friends and social activities that are so important to overall well-being. To explore the contradicting evidence in the literature about detrimental effects of social isolation and the SST theory, we conducted semi-structured interviews with 21 older adults ranging in age from 62 to 86 years old to explore their experiences during the pandemic and specifically to address emotional well-being, social experiences and coping mechanisms. Qualitative analyses revealed themes of problem-solving and emotion-focused coping, social support, and meaning making with ample evidence of the positivity effect. These findings support the SST theory as many participants expressed great resilience as they discussed how they engaged in emotionally meaningful activities and experiences and even made the best of adverse experiences during the pandemic

2.45 GHz Passive Wireless Temperature Monitoring System Featuring Parallel Sensor Interrogation and Resolution Evaluation

IEEE SENSORS 2006, EXCO, Daegu, Korea / October 22-25, 200